Radiation Exposure of Leukemia Blood Samples and Its Impacts on the Density of RBC, WBC, and PLT: &amp;lt;i&amp;gt;In Vitro&amp;lt;/i&amp;gt;

Ismail, Asaad H.; Hamad, Muhamad A.; Harki, Edrees M. T.

doi:10.4236/ojbiphy.2012.24016

Cited by 8 publications

(4 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, the result of the present study can be explained by the fact that the workers in the catheterization lab were not previously exposed to any substance that affected the hematological parameters as compared with the control. The present results show a behavior that is consistent with the results of Ismail et al [ 17 ] and Hamzah et al [ 18 ]. Moreover, these results are not consistent with reported investigations [ 9 ] in Iran that showed a linear relationship between exposure doses and blood parameters of staff working in catheterization laboratories who were exposed to continuous radiation.…”

Section: Discussionsupporting

confidence: 94%

Hematological and Cytogenetic Effects of X-rays in Cardiac Unit Workers and Catheterization Patients

Hussein,

Alasady,

Abdullah

2024

Cureus

View full text Add to dashboard Cite

Introduction X-rays are widely used in medicine for diagnosis and treatment. Such beneficial uses may cause potentially hazardous situations for patients and workers in the cardiac catheterization laboratory. The present study aims to estimate the radiation dose scattered in different parts of the catheterization units and doses absorbed by workers in this unit, and patients who underwent cardiac catheterization procedures to evaluate all changes in hematological parameters and damaged cells (the cells that contain a number of chromosomal aberrations) after exposure to radiation at Azadi Teaching Hospital in the Duhok City of Iraq. Methodology The study was conducted in one year and involved 19 male workers chronically exposed to X-ray machines in the cardiac catheterization laboratory, and 45 patients, 20 males and 25 females, who have been exposed to lower doses of X-ray during the cardiac catheterization process. There were 32 healthy individuals, 19 males and 13 females, as a control. Scattered radiation was calculated using an area monitoring detector. Optically Stimulated Luminescence (OSL) dosimeter and Flat Panel Detector (FPD) were used to calculate absorbed doses by workers and patients, respectively. Twelve hematological parameters before and after radiation were examined between study groups; the cytogenetic effects, damaged cells, and chromosomal aberrations of the white blood cells of workers, patients in the catheterization unit, and individuals of the control group were analyzed. Results The results showed that the scattered X-rays in the catheterization unit after one year of continuous detection did not change significantly compared to the data before the start of the trial. The results of all blood parameters looked to be significantly different (p<0.05) compared to the controls but within the normal range. There is no significant difference (p>0.05) in corpuscular hemoglobin, white blood cells, red distribution width, and neutrophil values for workers after one year of exposure as compared with the control. Also, there was no significant difference (p>0.05) in white blood cells, neutrophils, and monocyte values for patients after the operation. The current study showed the damaged cells in workers were significantly different compared to the control. At the same time, the differences were non-significant for all workers (p=0.0962) after one year of exposure. The differences in damaged cells in patients were highly significant after the operation (p=0.0003). The present study demonstrated that the inductions of dicentrics, acentric, chromosome break, and ring chromosomes in human lymphocytes were intimately related to the irradiation dose. Conclusions The present study found that the scattered X-rays in the catheterization unit after the end of the experiment did not change significantly. The current study also revealed that the exposure to X-rays had no significant effects on the blood indicators of workers and ...

show abstract

Section: Discussionsupporting

confidence: 94%

Hematological and Cytogenetic Effects of X-rays in Cardiac Unit Workers and Catheterization Patients

Hussein,

Alasady,

Abdullah

2024

Cureus

View full text Add to dashboard Cite

show abstract

“…Several previous studies related to the effect of radiation doses on RBC levels have been carried out. Ismail et al (2012) found that changes of the density of WBCs, PLTs, and RBCs were variable due to the exposure dose rate. The optimum exposed dose rate to make more adverse effects on the leukemia blood samples began at the radiation dose rate of 43.25 ± 1.206 μSv/h for males and females.…”

Section: Rbcs Dosementioning

confidence: 99%

“…The optimum exposed dose rate to make more adverse effects on the leukemia blood samples began at the radiation dose rate of 43.25 ± 1.206 μSv/h for males and females. Surely, it needs to be considered from the level of DNA damage, especially double-strand break [25]. Furthermore, several types of single nucleotide polymorphisms indicate an association with the level of DNA damage on cancer patients and play a role in the risk of obesity in Javanese ethnicity of Indonesia [26,27].…”

Section: Rbcs Dosementioning

confidence: 99%

Assessment of Ionizing Radiation Effects on the Hematological Parameters of Radiation-Exposed Workers

et al. 2019

View full text Add to dashboard Cite

“…worms and parasites. Granulocytes are dividing into monocytes (macrophages and dendrites) and lymphocytes (B-cells and T-cells) [2][3]. Their functions are to stimulate osteoclasts cells, antibodies and protein production, producing cytokines which help to direct to respond to calls, etc.…”

Section: Introductionmentioning

confidence: 99%

Experimental Evaluation of the Static Magnetic Field Effect on White Blood Cells:<i> In Viv</i>o Study

Mustafa

Yaba

Ismail

2020

MSF

View full text Add to dashboard Cite

In this study, we investigated the effect of the static magnetic field (SMF) on white blood cells (WBCs) for female albino rats using a fabricated exposure system of SMFs. Five main groups of animals exposed to 2.4±0.2 milli-Tesla (mT) for four weeks continuously. Five main groups (each group = 4 subgroups) have exposed to a different time of exposure; 1hr, 2hrs, 4hrs, 6hrs and 8hrs/day, respectively. Collected blood samples examined and compared with control values. The results proved that the time of exposure influences the WBCs significantly. One hour of exposure has increased the WBCs counts tremendously (from 50%-79%) in all weeks. However, the 8hrs of exposure reduced WBCs counts highly (from 71%-51%). The 3 weeks exposure trend was an increase, except the 8hrs/day exposure.

show abstract

Radiation Exposure of Leukemia Blood Samples and Its Impacts on the Density of RBC, WBC, and PLT: <i>In Vitro</i>

Cited by 8 publications

References 13 publications

Hematological and Cytogenetic Effects of X-rays in Cardiac Unit Workers and Catheterization Patients

Hematological and Cytogenetic Effects of X-rays in Cardiac Unit Workers and Catheterization Patients

Assessment of Ionizing Radiation Effects on the Hematological Parameters of Radiation-Exposed Workers

Experimental Evaluation of the Static Magnetic Field Effect on White Blood Cells:<i> In Viv</i>o Study

Contact Info

Product

Resources

About