Assessment of Ionizing Radiation Effects on the Hematological Parameters of Radiation-Exposed Workers

Surniyantoro, Harry Nugroho Eko; Rahardjo, Tur; Lusiyanti, Yanti; Rahajeng, Nastiti; Sadewa, Ahmad Hamim; Hastuti, Pramudji; Date, Hiroyuki

doi:10.17146/aij.2019.916

Cited by 10 publications

(7 citation statements)

References 15 publications

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“…Surniyantoro et al. (2019) 28 have reported that the percentage of non-smokers was higher, and, in general, the mean lymphocytes were lower, contrary to our findings. Cigarette smoke has been reported to damage artery walls, impair leukocyte and PLT function, and have immediate effects on endothelial cells.…”

Section: Discussioncontrasting

confidence: 99%

Effects of long-term X-ray exposure on CBC among radiological department staff in Sulaimani city

Mahmood,

Talabany,

Hama-Soor

2024

Journal of Taibah University Medical Sciences

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Section: Discussioncontrasting

confidence: 99%

Effects of long-term X-ray exposure on CBC among radiological department staff in Sulaimani city

Mahmood,

Talabany,

Hama-Soor

2024

Journal of Taibah University Medical Sciences

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“…The presence of SOD2 is important since damage to DNA and other molecules due to radiation are mostly caused by free radicals or indirect effects. This is because about 75 % of the mass of cells or tissues consists of water [12,23].…”

Section: Sod2mentioning

confidence: 99%

Priming Low-Dose Gamma Irradiation Increases Cellular Radioadaptation Response through the Induction of Hsp70 and SOD2

2021

Atom Indo.

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Exposure to low-dose radiation has been demonstrated to stimulate increased cell protection when receiving subsequent challenge dose in what is known as radioadaptation response. Hsp70 and SOD, especially SOD2, are cytoprotectors against superoxide radicals generated by radiation exposure. This study aims to measure the expressions of Hsp70 and SOD2 in parotid salivary gland acinar cells as an indicator of radioadaptation response stimulated by low-dose gamma irradiation. The study used 24 male Rattus norvegicus that are divided into four groups: normal control, positive control, with 50-mGy priming irradiation, and with 100-mGy priming irradiation. The animals were immobilized without anesthetics with special tools designed especially for this study. Irradiation was carried out using a cobalt-60 (gamma ray) teletherapy unit (Philips XK-100) directed to the dorsa of the animals' heads. High-dose gamma irradiation (2 Gy) was administered 5 hours after priming irradiation. The expression of Hsp70 and SOD2 was measured through immunohistochemical technique on the parotid salivary gland acinar cells and observed using a light microscope with 1000× magnification. Data obtained was analyzed with one-way ANOVA test (α = 0.05). The results showed that Hsp70 and SOD2 expressions in the priming irradiation groups were higher than those in control groups. The conclusion of this study: priming irradiation with low-dose gamma radiation before challenge irradiation with high-dose gamma radiation increases the radioadaptation response of salivary gland acinar cells through induction of Hsp70 and SOD2.

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“…Of all these cells, lymphocytes have been known to be one of the most radiosensitive mammalian cells. Several recent studies by Shahid et al [14], Gyuleva et al [15], and Surniyantoro et al [16] revealed significant differences in lymphocyte counts between radiation workers and the control population. Such a research on these impacts in the Mamuju area has never been done.…”

Section: Introduction mentioning

confidence: 99%

The Effects of High Level Natural Radiation in Mamuju - Indonesia on the Immune System of Its Residents

et al. 2022

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The immune system is one of the most significant defenses against environmental insults including natural radiation. The purpose of this preliminary study was to assess the effects of high natural radiation to Mamuju residents, by focusing on immune-related blood cell counts (leukocytes, lymphocytes, monocytes, and granulocytes) and immunoglobulin E (IgE) level. The blood samples were collected from 18 adult residents in a high background radiation area (HBRA) while 18 residents in a normal background radiation area (NBRA) served as a control group. The blood components were measured by using the hematopoietic analyzer, and IgE immune biomarker was measured with ELISA (enzyme-linked immunosorbent assay) according to standard protocols. The data showed that the level of all blood cells, except for monocytes, of residents in HBRA was higher than that of NBRA. Statistical analysis revealed that there was no significant difference (P>0.05) in the blood cell counts and IgE level in both groups and their values were within normal limits. The level of IgE in HBRA was significantly higher than the control area (P≤0.05), as its IgE level in males compared to females in both residents. The relationship between IgE level and age were negative in these residents. From this study, it was concluded that long-term exposure to high radiation may affect the immune system as one of radiation adaptive response.

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Assessment of Ionizing Radiation Effects on the Hematological Parameters of Radiation-Exposed Workers

Cited by 10 publications

References 15 publications

Effects of long-term X-ray exposure on CBC among radiological department staff in Sulaimani city

Effects of long-term X-ray exposure on CBC among radiological department staff in Sulaimani city

Priming Low-Dose Gamma Irradiation Increases Cellular Radioadaptation Response through the Induction of Hsp70 and SOD2

The Effects of High Level Natural Radiation in Mamuju - Indonesia on the Immune System of Its Residents

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