Interaction of Lymphocytes and Thyrocytes in Graves’ Disease and Nonautoimmune Thyroid Diseases in Immunohistochemical and Ultrastructural Investigations

Beń‐Skowronek, Iwona; Sierocinska-Sawa, Jadwiga; Szewczyk, Leszek; Korobowicz, E

doi:10.1159/000223420

Cited by 10 publications

(9 citation statements)

References 67 publications

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“…Moreover, MxA has been widely studied in serum from patients with multiple sclerosis, mainly as a measure for bioactivity of IFN treatment (36,37). We found that CD8 + T cells were mainly present at the chronic stage of GD, which is consistent with the findings of a previous study by Skowronek et al (38). IHC revealed a high percentage of CD8 + T cells compared with CD4 + T cells in the thyroid tissue of euthyroid children with GD.…”

supporting

confidence: 91%

Immunological Changes and Increased Expression of Myxovirus Resistance Protein A in Thyroid Tissue of Patients with Recent Onset and Untreated Graves' Disease

Hammerstad

Jahnsen

Tauriainen

et al. 2014

Thyroid

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The increase in CD8+ T cells during the chronic stage of GD suggests that they may play a role in progression of the autoimmune process from early to chronic thyroiditis. Upregulation of MxA expression during the early stages of the disease, and the positive correlation between the number of PDCs and the number of MxA+ leucocytes, suggests that activated PDCs secrete type I IFNs at the lesion site, possibly in response to viral infection.

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supporting

confidence: 91%

Immunological Changes and Increased Expression of Myxovirus Resistance Protein A in Thyroid Tissue of Patients with Recent Onset and Untreated Graves' Disease

Hammerstad

Jahnsen

Tauriainen

et al. 2014

Thyroid

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Section: Discussionmentioning

confidence: 94%

“…A total of 6.49% of T lymphocytes were CD8+ T lymphocyte and 2.95% CD4+ T lymphocyte. In addition, they also reported that lymphocytes infiltrations were dominated by CD79a+ B lymphocytes, which constituted 23.21% of the observed cells . However none of them detected the amount of the effect T cell, B cell, and regulatory T cells, respectively, in each thyroid specimen of AITD and discussed the correlationship among the three lymphocyte subsets.…”

Section: Discussionmentioning

confidence: 96%

Distribution of Lymphocyte Subpopulations in Thyroid Glands of Human Autoimmune Thyroid Disease

Zha

Huang

Lin

et al. 2014

J. Clin. Lab. Anal.

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Based on CD20+ B cells predominantly infiltrating in all HT thyroid tissues we suggested CD20 antibody might be of help for HT treatment. Furthermore based on FoxP3+ Tregs abundantly infiltrating in some of the AITD thyroid specimens, we considered that activating the Tregs' function in comparison to increasing the Tregs' number only, may be a more effective approach to the treatment of AITD in some cases.

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“…Thus, autoantibody-producing B lymphocytes are important contributors to GD pathogenesis. Moreover, lymphoid infiltrates in thyroid and retro-orbital tissue of GD patients consist of secondary lymphoid follicles containing both B and T lymphocytes [2,3]. Consequently, GD is currently considered as a B lymphocyte-mediated T lymphocyte-dependent autoimmune disease [4].…”

Section: Introductionmentioning

confidence: 99%

The peripheral blood compartment in patients with Graves' disease: activated T lymphocytes and increased transitional and pre-naive mature B lymphocytes

Weerd

Hagen

Schrijver

et al. 2013

Clinical and Experimental Immunology

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SummaryGraves' disease (GD) is an autoimmune disease that involves aberrant B and T lymphocyte responses. Detailed knowledge about lymphocyte subpopulation composition will therefore enhance our understanding of the pathogenesis of GD and might support the development of new immunomodulatory treatment approaches. The aim of this study was to gain detailed insight into the composition of the peripheral blood lymphocyte compartment in GD before and during anti-thyroid drug therapy. Major B and T lymphocyte subpopulations were investigated by flow cytometry in peripheral blood from newly diagnosed GD patients (n = 5), GD patients treated with anti-thyroid drugs (n = 4), patients with recurrent GD (n = 7) and healthy controls (HC; n = 10). In GD patients, numbers of activated T lymphocytes [human leucocyte antigen D-related (HLA-DR) + and CD25 + ] were increased. The B lymphocyte compartment in GD was characterized by significantly higher numbers of transitional (CD38 high CD27 − , P < 0·03) and pre-naive mature (CD38 low CD27− IgD + CD5 + , P < 0·04) B lymphocytes, while memory populations were slightly decreased. The increased numbers of CD5 + , transitional and pre-naive mature B lymphocytes correlated positively with fT4 plasma levels. GD is associated with increased numbers of activated T lymphocytes and transitional and pre-naive mature CD5 + B lymphocytes within the peripheral blood. The increase in CD5 + B lymphocytes was due mainly to an increase in transitional and pre-naive mature B lymphocytes. Increased fT4 plasma levels might be associated with this increase in transitional and pre-naive mature CD5 + B lymphocytes.

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Interaction of Lymphocytes and Thyrocytes in Graves’ Disease and Nonautoimmune Thyroid Diseases in Immunohistochemical and Ultrastructural Investigations

Cited by 10 publications

References 67 publications

Immunological Changes and Increased Expression of Myxovirus Resistance Protein A in Thyroid Tissue of Patients with Recent Onset and Untreated Graves' Disease

Immunological Changes and Increased Expression of Myxovirus Resistance Protein A in Thyroid Tissue of Patients with Recent Onset and Untreated Graves' Disease

Distribution of Lymphocyte Subpopulations in Thyroid Glands of Human Autoimmune Thyroid Disease

The peripheral blood compartment in patients with Graves' disease: activated T lymphocytes and increased transitional and pre-naive mature B lymphocytes

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