Interaction of malonaldehyde with collagen

Švadlenka, Ivan; Davídková, E.; Rosmus, Jan

doi:10.1007/bf01140364

Cited by 9 publications

(3 citation statements)

References 8 publications

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“…SOD constitutes an important link in the biological defence mechanism through disposition of endogenous cytotoxic O 2 2 , which are deleterious to polyunsaturated fatty acid, and structural proteins of plasma membrane. 45 Decreased GPx activity observed in our study could be due to exhaustion or inactivation of the enzyme by ROS, since oxidative damage to Hb and cell membrane has been reported to reduce the activity of GPx. 45 Thabrew et al apparently reported a decline in the activity of SOD and GPx in the erythrocytes of ADR administered rats, which corroborates with our study.…”

Section: Discussionmentioning

confidence: 56%

“…45 Decreased GPx activity observed in our study could be due to exhaustion or inactivation of the enzyme by ROS, since oxidative damage to Hb and cell membrane has been reported to reduce the activity of GPx. 45 Thabrew et al apparently reported a decline in the activity of SOD and GPx in the erythrocytes of ADR administered rats, which corroborates with our study. 44 Previously we have reported the beneficial effect of LA pretreatment in reversing the decline in the activity of serum CAT and GSH on ADR administration.…”

Section: Discussionmentioning

confidence: 56%

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Effect of lipoic acid on the oxidoreductive status of red blood cells in rats subject to oxidative stress by chronic administration of adriamycin

Malarkodi

Sivaprasad²,

Varalakshmi

2004

Hum Exp Toxicol

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One of the most intriguing phenomena observed during adriamycin (ADR) toxicity has been attributed to ADR-induced oxidative stress. The study was aimed to assess the protective effect of lipoic acid (LA) against ADR induced damage to erythrocytes. Male albino rats (Wistar strain) were subjected to ADR (1 mg/kg body weight/day i.v.) once a week for a period of 12 weeks. Haematological indices like haemoglobin levels (Hb) and haematocrit (Ht) were also lowered along with a marked increase in the activities of serum glutamate pyruvate transaminase (SGPT) and serum glutamate oxaloacetate transaminase (SGOT). These rats demonstrated enhanced erythrocyte membrane lipid peroxidation (LPO) and an onslaught in the antioxidant defence armoury, witnessed by lowered activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), vitamin A, vitamin C and vitamin E. Rats administered with ADR showed a marked decline in the activities of membrane-bound ATPases. Abnormal LPO and decreased deformability led to increased osmotic fragility of the red blood cells. Pretreatment with LA (35 mg/kg body weight/day i.p.) 24 hours prior to the administration of ADR once a week for a period of 12 weeks was effective in counteracting these biochemical disturbances, thereby minimizing the toxic side effects of ADR.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 56%

Effect of lipoic acid on the oxidoreductive status of red blood cells in rats subject to oxidative stress by chronic administration of adriamycin

Malarkodi

Sivaprasad²,

Varalakshmi

2004

Hum Exp Toxicol

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“…Decreased GPx activity observed in this study could be due to exhaustion or inactivation of the enzyme by ROS since oxidative damage to Hb and the cell membrane has been reported to reduce the activity of GPx. 57 GSH is involved in the detoxification of heavy metals as well as reactive metabolites of xenobiotics 58 by forming conjugates and by acting as a free radical scavenger. GSH plays a pivotal role in defending against oxidative haemolyses.…”

Section: Discussionmentioning

confidence: 99%

Combined efficacies of lipoic acid and meso-2,3-dimercaptosuccinic acid on lead-induced erythrocyte membrane lipid peroxidation and antioxidant status in rats

2003

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One of the most intriguing phenomenon observed during lead toxicity has been attributed to lead-induced oxidative stress. The combined effect of DL-a-lipoic acid (LA) and meso 2,3-dimercaptosuccinic acid (DMSA) on lead-induced alterations in selected parameters, which are indicators of oxidative stress in erythrocytes, have been studied. Lead acetate (Pb, 0.2%) was administered in drinking water for 5 weeks to induce toxicity. LA (25 mg/ kg body weight per day i.p.) and DMSA (20 mg/kg body weight per day i.p.) were administered individually and also in combination during week 6. Clinical evidence of toxic exposure was evident from the elevated blood lead levels (BPb) along with lowered levels of haemoglobin (Hb) and haematocrit (Ht). Lead-exposed animals showed enhanced membrane lipid peroxidation (LPO) in the erythrocytes. Damage to the erythrocyte membrane was evident from the decline in the activities of the trans-membrane enzymes, viz., Na1, K1 ATPase, Ca21 ATPase and Mg21 ATPase. Lead-exposed rats also suffered an onslaught on the antioxidant defence system witnessed by lowered activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and reduced glutathione (GSH). Serum glutamic-oxoloacetic transaminase (SGOT) and serum glutamic-pyruvic transaminase (SGPT) were also elevated in lead-exposed rats. Treatment with either LA or DMSA reversed the lead-induced biochemical disturbances encountered by the erythrocytes, but combined treatment with LA and DMSA was very effective in mitigating all the parameters indicative of oxidative stress.

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Interactions of oxidized lipids with protein Part XVI. Interactions of oxidized ethyl linoleate with collagen

Pokorný

Davı́dek

Chocholatá

et al. 1990

Nahrung

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The reaction of ethyl linoleate with collagen proceeded at 60 degrees C following the first order kinetics but during the hydroperoxide decomposition the rate constant of the first order decomposition was substantially lower than that of the second order decomposition. Contrary to cellulose, collagen catalyzed the hydroperoxide decomposition. The amount of total oxidation products rose rapidly at the stage of rapid hydroperoxide formation, and slowly afterwards. The browning reaction was fasted in the stage of maximum hydroperoxide content, and both ether-insoluble and ether-soluble pigments were formed, the latter low in nitrogen. The amount of lipid oligomers increased mainly in the reaction stage following the hydroperoxide maximum. Soluble collagen was converted into insoluble forms by the reaction with oxidized lipids. Basic amino acids were blocked by reaction with oxidized lipids but the bonds formed became resistant to acid hydrolysis only in the stage following the hydroperoxide maximum. Changes of sensory profiles could be explained by reactions of flavour-active carbonylic oxidation products with protein.

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Interaction of malonaldehyde with collagen

Cited by 9 publications

References 8 publications

Effect of lipoic acid on the oxidoreductive status of red blood cells in rats subject to oxidative stress by chronic administration of adriamycin

Effect of lipoic acid on the oxidoreductive status of red blood cells in rats subject to oxidative stress by chronic administration of adriamycin

Combined efficacies of lipoic acid and meso-2,3-dimercaptosuccinic acid on lead-induced erythrocyte membrane lipid peroxidation and antioxidant status in rats

Interactions of oxidized lipids with protein Part XVI. Interactions of oxidized ethyl linoleate with collagen

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