Interaction of MSC with tumor cells

Melzer, Catharina; Yang, Yuanyuan; Hass, Ralf

doi:10.1186/s12964-016-0143-0

Cited by 170 publications

(156 citation statements)

References 96 publications

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“…For instance, MSC-derived exosomes can influence the fate of nasopharyngeal carcinoma by modifying the expression of EMT markers [115]. In addition, the mechanisms of communication between MSC and tumor cells are well reviewed by Melzer and colleagues [116]. These findings strongly suggest that MSC-derived factors can play a key role in the regulation of solid tumor cell growth, apoptosis, and spreading.…”

Section: Msc Cross-talk With Tumor Cellsmentioning

confidence: 99%

Mesenchymal Stromal Cells Can Regulate the Immune Response in the Tumor Microenvironment

Poggi

Giuliani

2016

Vaccines

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The tumor microenvironment is a good target for therapy in solid tumors and hematological malignancies. Indeed, solid tumor cells’ growth and expansion can influence neighboring cells’ behavior, leading to a modulation of mesenchymal stromal cell (MSC) activities and remodeling of extracellular matrix components. This leads to an altered microenvironment, where reparative mechanisms, in the presence of sub-acute inflammation, are not able to reconstitute healthy tissue. Carcinoma cells can undergo epithelial mesenchymal transition (EMT), a key step to generate metastasis; these mesenchymal-like cells display the functional behavior of MSC. Furthermore, MSC can support the survival and growth of leukemic cells within bone marrow participating in the leukemic cell niche. Notably, MSC can inhibit the anti-tumor immune response through either carcinoma-associated fibroblasts or bone marrow stromal cells. Experimental data have indicated their relevance in regulating cytolytic effector lymphocytes of the innate and adaptive arms of the immune system. Herein, we will discuss some of the evidence in hematological malignancies and solid tumors. In particular, we will focus our attention on the means by which it is conceivable to inhibit MSC-mediated immune suppression and trigger anti-tumor innate immunity.

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Section: Msc Cross-talk With Tumor Cellsmentioning

confidence: 99%

Mesenchymal Stromal Cells Can Regulate the Immune Response in the Tumor Microenvironment

Poggi

Giuliani

2016

Vaccines

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“…For example, MSCs must be recruited to the site of tissue damage, a key factor of their application in regenerative medicine 13,14 . On the other hand, migration of MSCs into tumors promotes tumor growth and metastasis formation by the secretion of cytokines, growth factors, chemokines and many other soluble molecules [76][77][78][79][80][81][82][83][84][85][86] . Moreover, MSCs migrated into the tumor negatively modulate anti-cancer immunity via their interaction with immune cells [87][88][89] .…”

Section: Discussionmentioning

confidence: 99%

The voltage-gated proton channel hHv1 is functionally expressed in human chorion-derived mesenchymal stem cells

Mészáros

Papp

Mocsár

et al. 2020

Sci Rep

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The voltage-gated proton channel Hv1 is widely expressed, among others, in immune and cancer cells, it provides an efficient cytosolic H + extrusion mechanism and regulates vital functions such as oxidative burst, migration and proliferation. Here we demonstrate the presence of human Hv1 (hHv1) in the placenta/chorion-derived mesenchymal stem cells (cMSCs) using RT-PCR. The voltage-and pHdependent gating of the current is similar to that of hHv1 expressed in cell lines and that the current is blocked by 5-chloro-2-guanidinobenzimidazole (ClGBI) and activated by arachidonic acid (AA). Inhibition of hHv1 by ClGBI significantly decreases mineral matrix production of cMSCs induced by conditions mimicking physiological or pathological (inorganic phosphate, Pi) induction of osteogenesis. Wound healing assay and single cell motility analysis show that ClGBI significantly inhibits the migration of cMSCs. Thus, seminal functions of cMSCs are modulated by hHv1 which makes this channel as an attractive target for controlling advantages/disadvantages of MSCs therapy.Mesenchymal stem cells (MSCs) are multipotent cells with intensive proliferative capacity and ability to differentiate into various cell types (osteoblasts, chondroblasts, myocytes, adipocytes etc.) 1,2 . MSCs were originally isolated from bone marrow, and were found later in numerous organs and tissues, including adipose tissue, periosteum, synovial membrane, articular cartilage, umbilical cord and placenta, among others 1,3 . The use of MSCs is a novel therapeutic strategy for regenerative medicine 4,5 , however, their application is not limited to repairing and replacing the impaired organs, rather, the immunomodulatory and anti-inflammatory properties 5-9 of MSCs are also important 10,11 . Placenta-derived mesenchymal stem cells (cMSCs) possess excellent immunoregulatory properties, therefore, the chorionic plate of the placenta may be an attractive source for stem cells to be used in cell therapy and tissue engineering 3,12 . In most cases, systemic delivery is preferred for the clinical applications which requires the homing and migration of MSCs to the target tissue. In line with these MSCs have a capacity to migrate into the injured and inflamed environment 13,14 .Bioelectric signaling and pH regulation via ion channels and pumps are known to play a role in a wide range of cell functions, including cell proliferation, migration, differentiation, apoptosis but this aspect of stem cell biology seems to be poorly understood 10,15 . Multiple ion channels were reported earlier to be present in human MSCs, for example K + channels, Na + and Cl − channels 16,17 , but data are missing in the literature for the existence of the human voltage-gated proton channels (hHv1) in mesenchymal stem cells. At the same time hHv1 channels are widespread; they can be found in various mammalian cells [18][19][20][21][22][23][24] , such as macrophages 25 , B-lymphocytes 26,27 , oocytes 28 , osteoclasts 29,30 , skeletal muscle cells 31 , as well as cancer cells 32,33 , for exampl...

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“…This interaction is known to promote the metastatic ability of cancer cells by causing an increase in cancer stemness [2][3][4] , acquisition of the epithelial-mesenchymal transition phenotype via secretion of CXCR4, SDF-1, or TGF-β from stromal stem cells [28] , induction of regulatory T cells by stromal stem cells [2][3][4] , fusion of cancer cells with stromal stem cells [29] , and multicellular sphere formation of cancer cells and stromal cells [30] .…”

Section: Discussionmentioning

confidence: 99%

Fatty Acids Induce Stemness in the Stromal Cells of a CT26 Mouse Tumor Model

Kawahara

Mori²,

Goto³

et al. 2017

Pathobiology

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The potential effects of 2 types of fatty acids on colorectal cancer (CRC) were assessed using cancer stromal cells. Linoleic acid (LA; C-18, n-6 unsaturated fatty acid) and elaidic acid (EA; C-18, trans acid), both known to affect colon carcinogenesis and cancer progression, were administered by gavage to BALB/c mice, which were inoculated with CT26 syngeneic colon cancer cells in the back. Both EA and LA treatments enhanced tumor growth and metastasis. EA and LA also increased the number of CD133-positive stromal cells in the tumor capsule. Importantly, those cancer cells at the tumor periphery, physically attached to CD133-positive stromal cells, also expressed CD133. These findings suggest that EA and LA might induce stemness in cancer cells through physical association and promote cancer metastasis.

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Interaction of MSC with tumor cells

Cited by 170 publications

References 96 publications

Mesenchymal Stromal Cells Can Regulate the Immune Response in the Tumor Microenvironment

Mesenchymal Stromal Cells Can Regulate the Immune Response in the Tumor Microenvironment

The voltage-gated proton channel hHv1 is functionally expressed in human chorion-derived mesenchymal stem cells

Fatty Acids Induce Stemness in the Stromal Cells of a CT26 Mouse Tumor Model

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