Interaction of multiple drops and formation of toroidal-spiral particles

Plata, Paola Leon; Liu, Ying; Nitsche, Ludwig C.

doi:10.1103/physrevfluids.3.093601

Cited by 2 publications

(1 citation statement)

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“…Here, we present a particulate technology that can be potentially used for ACT delivery by a minimally invasive procedure to the tumor mass with well-controlled microenvironment for in vivo cell proliferation, activation, and release. These heterogeneous particles with toroidal-spiral (TS) internal structures were generated by a self-assembly process of polymeric droplet sedimentation in a miscible solution and subsequent polymer solidification initiated by a ultraviolet (UV) beam. , We previously demonstrated that these toroidal-spiral particles (TSPs) could be used for codelivery and controlled release of therapeutic agents of different sizes, such as a small molecular drug and a full-size antibody . The TSPs can have enormous flexibility for delivery of various therapeutic agents, including living cells.…”

Section: Introductionmentioning

confidence: 99%

Heterogeneous Polymeric Particles Encapsulating Human T cells for Controlled Activation, Proliferation, and Delivery

Liu¹,

León-Plata²,

Zaroudi³

et al. 2020

ACS Appl. Bio Mater.

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We report a particulate cell delivery platform, toroidal spiral particles (TSPs), for continuous cell activation, expansion, and local sustained release. Biocompatible TSPs, generated by a self-assembly process of polymeric droplet sedimentation in an aqueous solution and subsequent polymer solidification, possess many engineering design flexibilities to manipulate the microenvironment of the cells to control cell proliferation, migration, and release kinetics. These millimeter-size particles with desired mechanical and physicochemical properties may be potentially used for adoptive cellular therapy (ACT) delivery by a minimally invasive procedure to the tumor mass.

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Section: Introductionmentioning

confidence: 99%

Heterogeneous Polymeric Particles Encapsulating Human T cells for Controlled Activation, Proliferation, and Delivery

Liu¹,

León-Plata²,

Zaroudi³

et al. 2020

ACS Appl. Bio Mater.

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Manipulation of toroidal-spiral particles internal structure by fluid flow

2021

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We report on the precise manipulation of the fine structures of toroidal-spiral particles (TSPs) generated by a self-assembly process of droplet sedimentation at low Reynolds numbers in a miscible bulk solution followed by solidification. The biocompatible polymeric TSP can serve as a device for drug delivery and in vivo therapeutic cell expansion, activation, and delivery, for which highly tunable and reproducible structures are essential to design dosages and release kinetics. TSP formation can be divided into two stages: initial infusion of the drop vs its subsequent sedimentation, deformation, and entrainment of the surrounding bulk solution. The infusion rate affects the drop shape and tail length. These two features represent crucial initial conditions for subsequent shape evolution, which determines the overall morphology of the TSP and fine structure of the internal channel. Our computer simulations of drop dynamics add a new capability to the swarm-of-Stokeslets technique: unequal viscosities of the drop and bulk phases (i.e., non-unit viscosity ratio). During sedimentation, the density difference between the droplet and the bulk solution played a more pronounced role than the viscosity ratio, which was revealed both by experimental observations and numerical simulations. Understanding the fundamental hydrodynamics and developing a flow map will ultimately aid in the design of TSPs with tunable empty channels toward drug delivery and cell encapsulation.

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Interaction of multiple drops and formation of toroidal-spiral particles

Cited by 2 publications

References 141 publications

Heterogeneous Polymeric Particles Encapsulating Human T cells for Controlled Activation, Proliferation, and Delivery

Heterogeneous Polymeric Particles Encapsulating Human T cells for Controlled Activation, Proliferation, and Delivery

Manipulation of toroidal-spiral particles internal structure by fluid flow

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