Interaction of Mycobacterium avium subsp. paratuberculosis with bovine sperm

Caldeira, Jéssica Lobo Albuquerque; Faria, Ana Carolina Silva de; Diaz-Miranda, Edgar Andres; Zilch, Tiago J.; Caliman, Sanely Lourenço da Costa; Okano, Denise Silva; Guimarães, Mário; Pena, Junnia Luisa; Barbosa, Wagner Faria; Silva-Júnior, Abelardo; Chang, Yung-Fu; Moreira, Maria Aparecida Scatamburlo

doi:10.1016/j.theriogenology.2020.12.007

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…For this reason, the semen was considered to be of poor quality, but these authors indicated that this low seminal quality was due mainly to malnutrition and the poor corporal condition of the animal and was not a consequence of infection with MAP. In addition, Caldeira et al (2021) described that Bulls Nelore semen inoculated with MAP (10 3 to 10 8 CFU/mL) generates a decrease in sperm motility and vigor, which is possibly due to the adhesion of MAP with the intermediate part (tail) of the sperm, region containing a large amount of fibronectin in the plasma membrane. Since the infection in the rams of this study was acquired naturally, it should be noted that the duration of the period of this infection is unknown.…”

Section: Seminal Qualitymentioning

confidence: 99%

Reproductive and seminal characteristics of Pelibuey rams infected with Mycobacterium avium subsp. paratuberculosis in the subclinical stage

Vel´ázquez-Morales

Santillán-Flores²,

Navarro-Maldonado³

et al. 2023

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Objective: To evaluate the reproductive and seminal characteristics of Pelibuey rams infected with Mycobacterium avium subsp. paratuberculosis in the subclinical phase. Design/methodology/approach: In order to determine whether paratuberculosis (PTB) affects the reproductive variables and seminal quality in Pelibuey rams naturally infected with Mycobacterium avium subsp. paratuberculosis (MAP) in the subclinical phase, weekly evaluations were conducted, over a period of two months, of the variables live weight, scrotal circumference, ejaculation latency and seminal characteristics: volume, pH, masal motility and progressive individual motility, concentration, live spermatozoids and dead spermatozoids, in five rams infected by MAP and a further five uninfected rams, of average weight and age 53.58 kg (± 3.26) and 2.91 years (± 0.59), respectively. Results: PTB was not found to affect the reproductive and seminal variables evaluated. Limitations of the study/implications: It would have been convenient to carry out the evaluation of the seminal characteristics for a longer time, however, the sampling was stopped in order to ensure the animal welfare of the rams as far as possible, since they began to show signs of PTB. Findings/Conclusions: The Pelibuey rams diagnosed with PTB in subclinical phase did not present any effect on the reproductive and seminal characteristics. Meanwhile, reproductive management can be carried out with PTB-infected Pelibuey lambs in a subclinical phase.

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Section: Seminal Qualitymentioning

confidence: 99%

Reproductive and seminal characteristics of Pelibuey rams infected with Mycobacterium avium subsp. paratuberculosis in the subclinical stage

Vel´ázquez-Morales

Santillán-Flores²,

Navarro-Maldonado³

et al. 2023

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“…In Canada, the economic losses associated with JD in dairy herds were estimated to be more than US$35–57/year/cow [ 4 ]. The disease may cause profuse chronic diarrhea, submandibular edema, weight loss despite normal appetite, malnutrition, lethargy, and even death [ 5 ]. Mycobacterium avium subsp.…”

Section: Introductionmentioning

confidence: 99%

Analysis of long non-coding RNA expression profile of bovine monocyte-macrophage infected by Mycobacterium avium subsp. paratuberculosis

Yang

et al. 2022

BMC Genomics

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Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of paratuberculosis. As a potential zoonotic pathogen, MAP also seriously threatens human health and social security. At present, long non-coding RNA (lncRNA) has attracted wide attention as an useful biomarker in various diseases. Therefore, our study analyzed the lncRNA expression profiles and lncRNA-mRNA regulatory network of MAP infected bovine monocytes-macrophages and uninfected bovine cells by high-throughput sequencing. A total of 4641 differentially expressed lncRNAs genes were identified, including 3111 up-regulated genes and 1530 down-regulated genes. In addition, lncRNA-mRNA interaction analysis was performed to predict the target genes of lncRNA. Among them, after MAP infection, 86 lncRNAs targeted to mRNA, of which only 6 genes were significantly different. The results of Gene Ontology (GO) enrichment analysis showed that the differentially expressed genes significantly enriched in functional groups were related to immune regulation. Multiple signal pathways including NF-κB, NOD-like receptor, Cytokine-cytokine receptor, Toll-like receptor signaling pathway, Chemokine signaling pathway, and other important biochemical, metabolic and signal transduction pathways were enriched in Kyoto Encyclopedia of Genes and Genomes (KEGG). In this study, analysis of macrophage transcriptomes in response to MAP infection is expected to provide key information to deeply understand role of the pathogen in initiating an inappropriate and persistent infection in susceptible hosts and molecular mechanisms that might underlie the early phases of paratuberculosis.

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Proteomic profiling of membrane vesicles from Mycobacterium avium subsp. paratuberculosis: Navigating towards an in silico design of a multi-epitope vaccine targeting membrane vesicle proteins

Lee,

Abdullah,

Liu

et al. 2024

Journal of Proteomics

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Interaction of Mycobacterium avium subsp. paratuberculosis with bovine sperm

Cited by 3 publications

References 26 publications

Reproductive and seminal characteristics of Pelibuey rams infected with Mycobacterium avium subsp. paratuberculosis in the subclinical stage

Reproductive and seminal characteristics of Pelibuey rams infected with Mycobacterium avium subsp. paratuberculosis in the subclinical stage

Analysis of long non-coding RNA expression profile of bovine monocyte-macrophage infected by Mycobacterium avium subsp. paratuberculosis

Proteomic profiling of membrane vesicles from Mycobacterium avium subsp. paratuberculosis: Navigating towards an in silico design of a multi-epitope vaccine targeting membrane vesicle proteins

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