Interaction of nano carbon particles and anthracene with pulmonary surfactant: The potential hazards of inhaled nanoparticles

Zhao, Qun; Li, Yingjie; Chai, Xintao; Zhang, Linfeng; Xu, Linzhen; Huang, Jianhong; Ning, Ping; Tian, Senlin

doi:10.1016/j.chemosphere.2018.10.016

Cited by 37 publications

(24 citation statements)

References 46 publications

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“…A variety of nanoparticles, such as simple metal oxides [ [96] , [97] , [98] , [99] , [100] ], non-metal oxides [ 101 , 102 ], polymer-coated and polymer nanoparticles [ [103] , [104] , [105] ], metal nanoparticles [ [106] , [107] , [108] ], carbon nanomaterials [ 100 , 109 ], and other compounds containing carcinogenic matters [ [110] , [111] , [112] , [113] ], have been investigated in the studies of particle-surfactant interactions. A few studies on environmental PM dust exposure have also been conducted [ 110 , 114 , 115 ], but they are still in the very early stage compared to those using engineered nanoparticles.…”

Section: Interactions Of Particulate Matter and Pulmonary Surfactantmentioning

confidence: 99%

“…The manual mixing disqualifies this exposure method to simulate the natural inhalation process. Another method is dispersing particles in a subphase and a lipid solution is spread on the interface either after [ 96 , 98 , 109 , [127] , [128] , [129] ] or before particle dispersion [ 99 ], as in the latter situation the particle solution is injected through the lipid film to the subphase. This method is adequate to study adsorption behavior but requires a large number of particles, and the diffusion of colloidal particles in subphase would greatly affect the adsorption process.…”

Section: Interactions Of Particulate Matter and Pulmonary Surfactantmentioning

confidence: 99%

“…The presence of surfactant proteins also results in a higher foaming ability, which is an essential property for the surfactant to maintain interfacial property [ 111 ]. The foaming ability would be attenuated by NPs [ 109 ].…”

Section: Interactions Of Particulate Matter and Pulmonary Surfactantmentioning

confidence: 99%

“…Zhao et al . [ 109 ] found that unsaturated lipids DOPC displayed a synergistic solubilization effect with DPPC to increase the total solubilizing ability of natural pulmonary surfactant on PAHs particles.…”

Section: Interactions Of Particulate Matter and Pulmonary Surfactantmentioning

confidence: 99%

“…Zhao et al . [ 109 ] revealed that natural surfactant increased the solubilization of anthracene significantly, depressing the adsorption of anthracene to nanoparticles, thus the adsorption of anthracene to pulmonary surfactant was enhanced, which led to increased toxicity of the inhaled particles. Zhao et al .…”

Section: Interactions Of Particulate Matter and Pulmonary Surfactantmentioning

confidence: 99%

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Interactions of particulate matter and pulmonary surfactant: Implications for human health

Wang

Liu

Zeng

2020

Advances in Colloid and Interface Science

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Particulate matter (PM), which is the primary contributor to air pollution, has become a pervasive global health threat. When PM enters into a respiratory tract, the first body tissues to be directly exposed are the cells of respiratory tissues and pulmonary surfactant. Pulmonary surfactant is a pivotal component to modulate surface tension of alveoli during respiration. Many studies have proved that PM would interact with pulmonary surfactant to affect the alveolar activity, and meanwhile, pulmonary surfactant would be adsorbed to the surface of PM to change the toxic effect of PM. This review focuses on recent studies of the interactions between micro/nanoparticles (synthesized and environmental particles) and pulmonary surfactant (natural surfactant and its models), as well as the health effects caused by PM through a few significant aspects, such as surface properties of PM, including size, surface charge, hydrophobicity, shape, chemical nature, etc. Moreover, in vitro and in vivo studies have shown that PM leads to oxidative stress, inflammatory response, fibrosis, and cancerization in living bodies. By providing a comprehensive picture of PM-surfactant interaction, this review will benefit both researchers for further studies and policy-makers for setting up more appropriate regulations to reduce the adverse effects of PM on public health.

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Section: Interactions Of Particulate Matter and Pulmonary Surfactantmentioning

confidence: 99%

Section: Interactions Of Particulate Matter and Pulmonary Surfactantmentioning

confidence: 99%

Section: Interactions Of Particulate Matter and Pulmonary Surfactantmentioning

confidence: 99%

Section: Interactions Of Particulate Matter and Pulmonary Surfactantmentioning

confidence: 99%

Section: Interactions Of Particulate Matter and Pulmonary Surfactantmentioning

confidence: 99%

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Interactions of particulate matter and pulmonary surfactant: Implications for human health

Wang

Liu

Zeng

2020

Advances in Colloid and Interface Science

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Silica nanoparticle exposure inhibits surfactant protein A and B in A549 cells through ROS‐mediated JNK/c‐Jun signaling pathway

Yang

Zhang

et al. 2022

Environmental Toxicology

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Exposure to silica nanoparticles (SiNPs) is related to the dysregulation of pulmonary surfactant that maintains lung stability and function. Nevertheless, there are limited studies concerning the interaction and influence between SiNPs and pulmonary surfactant, and the damage and mechanism are still unclear. Herein, we used A549 cells to develop an in vitro model, with which we investigated the effect of SiNPs exposure on the expression of pulmonary surfactant and the potential regulatory mechanism. The results showed that SiNPs were of cytotoxicity in regarding of reduced cell viability and promoted the production of excessive reactive oxygen species (ROS). Additionally, the JNK/c‐Jun signaling pathway was activated, and the expression of surfactant protein A (SP‐A) and surfactant protein B (SP‐B) was decreased. After the cells being treated with N‐acetyl‐L‐cysteine (NAC), we found that the ROS content was effectively downregulated, and the expression of proteins related to JNK and c‐Jun signaling pathways was suppressed. In contrast, the expression of SP‐A and SP‐B was enhanced. Furthermore, we treated the cells with JNK inhibitor and c‐Jun‐siRNA and found that the expression of protein related to JNK and c‐Jun signaling pathways, as well as SP‐A and SP‐B, changed in line with that of NAC treatment. These findings suggest that SiNPs exposure can upregulate ROS and activate the JNK/c‐Jun signaling pathway in A549 cells, thereby inhibiting the expression of SP‐A and SP‐B proteins.

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Safer-by-design for nanomaterials

Reijnders

2020

Nanotoxicity

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Interaction of nano carbon particles and anthracene with pulmonary surfactant: The potential hazards of inhaled nanoparticles

Cited by 37 publications

References 46 publications

Interactions of particulate matter and pulmonary surfactant: Implications for human health

Interactions of particulate matter and pulmonary surfactant: Implications for human health

Silica nanoparticle exposure inhibits surfactant protein A and B in A549 cells through ROS‐mediated JNK/c‐Jun signaling pathway

Safer-by-design for nanomaterials

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