Interaction of nutrition and infection: effect of zinc deficiency on resistance to Trypanosoma musculi

Lee, Clarence M.; Humphrey, Patricia A.; Aboko-Cole, Georgiana F.

doi:10.1016/0020-711x(83)90156-8

Cited by 22 publications

(9 citation statements)

References 32 publications

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“…On the other hand, the trophozoites were only detected in the infected Table 1 Comparison of weights between the Giardia-free and Giardia-infected groups before the administration of the experimental diet (baseline) and 14 [34]. Zinc-deficient mice infected with Trypansoma musculi harbored three times more parasites than uninfected mice because of a delay in the production of protective antibodies [35]. Further, 40% of moderately zinc-deficient mice succumbed to a normally nonlethal infection of Plasmodium yoelii 17XNL malaria [36] because of delayed protection of immunoglobulin G antibodies.…”

Section: Discussionmentioning

confidence: 98%

Changes in Serum Zinc Levels Associated with Giardiasis and Dietary Zinc Intake in Mice

Quihui‐Cota

Estrada

Astiazarán-García

et al. 2011

Biol Trace Elem Res

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The association of giardiasis with the malabsorption of zinc remains controversial. This study investigated changes in serum zinc levels in Giardia-infected mice subjected to different dietary zinc regimens. Thirty-five mice (strain C(3)H/H(e)J) were randomly categorized into two groups. The first group was inoculated with 5 × 10(6) Giardia trophozoites (n = 18), and the second group remained Giardia free (n = 17). Each group (Giardia infected and Giardia free) was randomly classified into three subgroups and given low (9 mg Zn/kg), normal (33 mg Zn/kg), and high levels (288 mg Zn/kg) of dietary zinc over a 2-week period for acclimation. Fourteen days post-Giardia infection, all of the mice were euthanized and blood samples were collected. The number of trophozoites was quantified (hematocytometer), and serum zinc levels were determined via atomic absorption spectrophotometry. Significant increases in the median weights were only found in the Giardia-free mice (p < 0.05). A higher final median weight was found in the Giardia-free group when compared with that of the Giardia-infected group given low dietary zinc (p = 0.013). In the Giardia-infected group with low dietary zinc, the geometric mean of trophozoites was 3,498 ± 101 (SE) per milliliter. The Giardia-infected group had lower serum zinc levels than did the Giardia-free group with the high dietary zinc regimens (p < 0.05). Our results are consistent with studies among human populations, but further studies are required to elucidate the actual mechanism governing the zinc-giardiasis interaction.

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Section: Discussionmentioning

confidence: 98%

Changes in Serum Zinc Levels Associated with Giardiasis and Dietary Zinc Intake in Mice

Quihui‐Cota

Estrada

Astiazarán-García

et al. 2011

Biol Trace Elem Res

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“…In an investigation, decrease in zinc levels coincided with the onset of T. brucei gambiense in peripheral blood of rabbit (Mwangi et al, 1995). Zinc-deficient animals showed three times the number of trypanosomes as that of the complete and pairfed mice (Lee et al, 1983).…”

Section: Introductionmentioning

confidence: 99%

“…Zinc is known to play a central role in the immune system, and zinc-deficient persons experience increased susceptibility to a variety of pathogens (Shankar and Prasad, 1998) such as Trypanosoma cruzi (Fraker et al, 1982) and Trypanosoma musculi (Lee et al, 1983). Severe zinc deficiency is characterised by severely depressed immune function, frequent infections, bullous pustular dermatitis, diarrhoea, alopecia, and mental disturbances (Shankar and Prasad, 1998).…”

Section: Introductionmentioning

confidence: 99%

The beneficial effect of dietary zinc supplementation on anaemia and immunosuppression in Trypanosoma brucei infected rats

Eze

Ayogu

Abonyi

et al. 2015

Experimental Parasitology

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“…Zincdeficient mice infected with various parasites [39] harbored more than three times as many parasites as control mice. We have reported that mice supplemented with zinc and infected with T. crassiceps cysticerci presented with 50% less cysticerci than nontreated mice upon infection [27].…”

Section: Discussionmentioning

confidence: 99%

Interleukin‐1α, tumor necrosis factor‐α, and interleukin‐12 secreted by zinc‐induced murine macrophages in vivo and in vitro

Lastra

Aguilar

Cabañas

et al. 2004

J Trace Elements Exper Med

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Oral treatment of zinc modulates cytokine secretion during the gestation, lactation, and weaning periods. We used a experimental mice model of zinc supplementation during the perinatal stages to study the effects of this ion over the production of interleukin IL-1a, 2 IL-12, and tumor necrosis factor-alpha by peritoneal macrophages. In addition, we determined the gene expression of these cytokines. Zinc (500 mg/L) was orally administered to mice from gestation to lactation (6-week treatment, Zn+) and weaning (9-week treatment). The serum cytokines IL-1a and IL-12 were assayed in the offspring at 21 and 42 days after birth. Our results showed a significant (P < 0.01) increase in cytokine production in the Zn+ animals at the end of the lactation stage. There was a tendency for the IL-1 concentration to decrease at postweaning; nevertheless, IL-12 concentrations were increased in mice at 42 days of age (P < 0.001). The production of IL-1a, IL-12, and tumor necrosis factor-alpha in the macrophages supernatants in vitro followed the same tendencies (P < 0.001). Molecular analysis showed an increase of mRNA synthesis in all cases, from 4-fold to 6-fold, in the cytokines analyzed. Our results suggest that the increase in the proinflammatory cytokines as a result of zinc administration may potentiate Th1 cells response, which could lead to the increase of cytokine production in deficient newborns. J. Trace Elem.

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Interaction of nutrition and infection: effect of zinc deficiency on resistance to Trypanosoma musculi

Cited by 22 publications

References 32 publications

Changes in Serum Zinc Levels Associated with Giardiasis and Dietary Zinc Intake in Mice

Changes in Serum Zinc Levels Associated with Giardiasis and Dietary Zinc Intake in Mice

The beneficial effect of dietary zinc supplementation on anaemia and immunosuppression in Trypanosoma brucei infected rats

Interleukin‐1α, tumor necrosis factor‐α, and interleukin‐12 secreted by zinc‐induced murine macrophages in vivo and in vitro

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