Interaction of palladium(II) coordination compounds with calf thymus DNA and their antibacterial activity

Patel, Mohan N.; Dosi, Promise A.; Bhatt, Bhupesh S.

doi:10.1016/j.inoche.2012.04.011

Cited by 21 publications

(2 citation statements)

References 20 publications

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“…In recent years, the interaction mechanism of deoxyribonucleic acid (DNA) with small molecules has been the subject of extensive study, especially in interaction with drugs [1][2][3][4][5], chemical composition of plant extracts [6] and coordination compound [7]. When investigating the binding of a drug to DNA, one initial goal is to probe its binding mode to DNA.…”

Section: Introductionmentioning

confidence: 99%

Binding studies of terbutaline sulfate to calf thymus DNA using multispectroscopic and molecular docking techniques

Zhao

Wang

et al. 2015

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Section: Introductionmentioning

confidence: 99%

Binding studies of terbutaline sulfate to calf thymus DNA using multispectroscopic and molecular docking techniques

Zhao

Wang

et al. 2015

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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“…Therefore, many new complexes have been synthesized and characterized in order to overcome the disadvantages of cisplatin. Given the similar structures, hybridization, chemical properties and coordination modes of palladium(II) and platinum(II), there has been much interest in the design of palladium(II) derivatives . Cyclopalladated complexes are heterocyclic compounds containing palladium as one of the central heteroatoms and are usually characterized by the presence of a Pd─C bond stabilized by intramolecular coordination .…”

mentioning

confidence: 99%

Synthesis, characterization and biological activities of two novel orthopalladated complexes: Interactions with DNA and bovine serum albumin, antitumour activity and molecular docking studies

Karami

Hashemi

Lipkowski

et al. 2017

Applied Organom Chemis

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[Pd(L 1 )(C,N)]CF 3 SO 3 and [Pd(L 2 )(C,N)]CF 3 SO 3 (L 1 = 2,2′-bipyridine, L 2 = 1,10-phenanthroline and C,N = benzylamine) novel orthopalladated complexes have been synthesized and characterized using various techniques. The binding of the complexes with native calf thymus DNA (CT-DNA) was monitored using UVvisible absorption spectrophotometry, fluorescence spectroscopy and thermal denaturation studies. Our results indicate that these complexes can strongly bind to CT-DNA via partial intercalative mode. In addition, fluorescence spectrometry of bovine serum albumin (BSA) with the complexes shows that the fluorescence quenching mechanism of BSA is a static process. The results of site-competitive replacement experiments with specific site markers clearly indicate that the complexes bind to site I of BSA. Notably, the complexes exhibit significant in vitro cytotoxicity against two human cancer cell lines (Jurkat and MCF-7) with IC 50 values varying from 37 to 53 μM. Finally, a molecular docking experiment effectively proves the binding of the Pd(II) complexes to DNA and BSA.

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Binding Studies of Isoxsuprine Hydrochloride to Calf Thymus DNA Using Multispectroscopic and Molecular Docking Techniques

et al. 2017

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In the present work, the interaction of Isoxsuprine (ISX) with Calf thymus DNA (ct-DNA) under physiological conditions (Tris-HCl buffer of pH 7.4) was investigated by using electronic absorption, circular dichroism, viscosity, electrochemical studies, fluorescence techniques, salt effect studies and computational studies. Competitive fluorimetric studies with Hoechst 33258 have shown that ISX exhibit the ability to displace the DNA-bound Hoechst 33258, indicating that it binds to ct-DNA in strong competition with Hoechst 33258 for the minor groove binding. Furthermore, the resulting data showed that ISX cannot displace methylene blue or acridine orange, which are the common intercalator molecules. The viscosity of ct-DNA solution was almost unchanged on addition of ISX and circular dichroism (CD) spectra of ct-DNA showed small changes in the presence of ISX which is in agreement with groove binding mode of interaction. Thus all above studies showed that the ISX drug binds to ct-DNA in a groove binding mode.The salt-effect studies showed the non-electrostatic nature of binding of ISX to ct-DNA. Moreover, molecular docking results support the above experimental data and suggest that ISX prefers to bind on the minor groove of ct-DNA.

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Interaction of palladium(II) coordination compounds with calf thymus DNA and their antibacterial activity

Cited by 21 publications

References 20 publications

Binding studies of terbutaline sulfate to calf thymus DNA using multispectroscopic and molecular docking techniques

Binding studies of terbutaline sulfate to calf thymus DNA using multispectroscopic and molecular docking techniques

Synthesis, characterization and biological activities of two novel orthopalladated complexes: Interactions with DNA and bovine serum albumin, antitumour activity and molecular docking studies

Binding Studies of Isoxsuprine Hydrochloride to Calf Thymus DNA Using Multispectroscopic and Molecular Docking Techniques

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