Interaction of pyrophosphate with calcium phosphates

Vasudevan, T.; Somasundaran, P.; Howie-Meyers, C. L.; Elliott, D. L.; Ananthapadmanabhan, K.P.

doi:10.1021/la00013a047

Cited by 24 publications

(12 citation statements)

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“…the chemical environment of Ca is somewhat different from that in Ca 2 Fe(OH) 6 Cl·2H 2 O. This shift could be attributed to Ca-phosphate bond [30], supposedly due to the formation of Ca 2+ -TPP amorphous precipitate.…”

Section: Samplementioning

confidence: 84%

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Enhanced removal of triphosphate by MgCaFe-Cl-LDH: Synergism of precipitation with intercalation and surface uptake

Zhou

Qiao

et al. 2011

Journal of Hazardous Materials

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Section: Samplementioning

confidence: 84%

“…5(d)) was observed at 133.6 eV in P-Ca 2 FeCl-LDH (the same as in Na 5 P 3 O 10 ) while 134.6 eV in P-HCa 2 FeCl-LDH. The peak around 133.6 eV could be assigned to P 3 O 10 while 134.6 eV to PO 4 [30]. The only PO 4 peak in P-HCa 2 FeCl-LDH implies the more hydrolysis of P 3 O 10 into PO 4 .…”

Section: Samplementioning

confidence: 94%

Enhanced removal of triphosphate by MgCaFe-Cl-LDH: Synergism of precipitation with intercalation and surface uptake

Zhou

Qiao

et al. 2011

Journal of Hazardous Materials

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“…CPP is thought to inhibit CaP growth through an adsorption mechanism, similar to that of amino acids [29]. An increase in negatively charged phosphate groups, such as is found in polyphosphoserine, should enhance the inhibitory ability of the molecule and be a possible candidate for treatment and prevention of pathogenic CaPs.…”

Section: Discussionmentioning

confidence: 99%

Controlled synthesis of dicalcium phosphate dihydrate (DCPD) from metastable solutions: insights into pathogenic calcification

Rafeek

Choi

Evans

2021

J Mater Sci: Mater Med

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Calcium phosphate (CaP) compounds may occur in the body as abnormal pathogenic phases in addition to their normal occurrence as bones and teeth. Dicalcium phosphate dihydrate (DCPD; CaPO4·2H2O), along with other significant CaP phases, have been observed in pathogenic calcifications such as dental calculi, kidney stones and urinary stones. While other studies have shown that polar amino acids can inhibit the growth of CaPs, these studies have mainly focused on hydroxyapatite (HAp; Ca10(PO4)6(OH)2) formation from highly supersaturated solutions, while their effects on DCPD nucleation and growth from metastable solutions have been less thoroughly explored. By further elucidating the mechanisms of DCPD formation and the influence of amino acids on those mechanisms, insights may be gained into ways that amino acids could be used in treatment and prevention of unwanted calcifications. The current study involved seeded growth of DCPD from metastable solutions at constant pH in the presence of neutral, acidic and phosphorylated amino acid side chains. As a comparison, solutions were also seeded with calcium pyrophosphate (CPP; Ca2P2O7), a known calcium phosphate inhibitor. The results show that polar amino acids inhibit DCPD growth; this likely occurs due to electrostatic interactions between amino acid side groups and charged DCPD surfaces. Phosphoserine had the greatest inhibitory ability of the amino acids tested, with an effect equal to that of CPP. Clustering of DCPD crystals giving rise to a “chrysanthemum-like” morphology was noted with glutamic acid. This study concludes that molecules containing an increased number of polar side groups will enhance the inhibition of DCPD seeded growth from metastable solutions.

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“…Zeta potential measurements were carried out on a Zetasizer Nano Z system (Malvern). Vasudevan et al found the zeta potential of pure CPPD crystals as −41 mV. The results of zeta potential measurements agreed with this value in our study.…”

Section: Methodsmentioning

confidence: 99%

Effects of L‐Serine and L‐Proline on Crystallization Kinetics of Calcium Pyrophosphate Dihydrate

2018

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Calcium pyrophosphate dihydrate (CPPD) crystallization was investigated in a mixed‐suspension mixed‐product removal (MSMPR)‐type crystallizer in the presence of the amino acids L‐serine and L‐proline as additives. Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and zeta potential analysis were applied for characterization of the crystals obtained. CPPD crystals obtained in pure media consisted of aggregated particles which included plate‐like structures and rod‐shaped crystals. However, it was observed that agglomeration and breakage tendency on CPPD crystals obtained in the presence of amino acids were remarkable. The population balance equation for CPPD crystals was resolved with numerical analysis considering aggregation and breakage steps. The predominant mechanism was the breakage for CPPD crystallization in the presence of amino acids.

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Interaction of pyrophosphate with calcium phosphates

Cited by 24 publications

References 0 publications

Enhanced removal of triphosphate by MgCaFe-Cl-LDH: Synergism of precipitation with intercalation and surface uptake

Enhanced removal of triphosphate by MgCaFe-Cl-LDH: Synergism of precipitation with intercalation and surface uptake

Controlled synthesis of dicalcium phosphate dihydrate (DCPD) from metastable solutions: insights into pathogenic calcification

Effects of L‐Serine and L‐Proline on Crystallization Kinetics of Calcium Pyrophosphate Dihydrate

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