Interaction of Sesamin and Eicosapentaenoic Acid against<i>Δ</i>5 Desaturation and n-6/ n-3 Ratio of Essential Fatty Acids in Rat

Umeda-Sawada, Rumi; Takahashi, N.; Igarashi, Osamu

doi:10.1271/bbb.59.2268

Cited by 22 publications

(20 citation statements)

References 9 publications

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“…Each of the two diets was then split into two groups: with (COS and AOS) or without (CO and AO) 0.5% (w/w) of sesame lignans. The percentage of AA in AO and AOS diets is the same as that of EPA in the EPA-rich oil group in our previous study (13). The level of total n-6 PUFA is the same in all groups.…”

Section: Methodssupporting

confidence: 64%

“…We also found that sesame lignans increased the content of n-6 fatty acids, especially AA, but decreased the content of n-3 fatty acids, especially EPA, in rat liver, when EPA-rich diet was given (13). Consequently, the n-6/n-3 ratio in vivo was significantly reduced in the EPA-rich group but returned to almost the original level when administered with sesame lignans (13).…”

mentioning

confidence: 54%

“…In our previous studies, we reported that sesame lignans inhibited ∆5 desaturation from DGLA (n-6) to arachidonic acid (AA, n-6), but not from 20:4n-3 to eicosapentaenoic acid (EPA, n-3) in cultured rat hepatocytes (12) and in vivo (13). We also found that sesame lignans increased the content of n-6 fatty acids, especially AA, but decreased the content of n-3 fatty acids, especially EPA, in rat liver, when EPA-rich diet was given (13).…”

mentioning

confidence: 98%

“…In this report, we will focus on the effect of dietary AA and sesame lignans on fatty acid metabolism compared to that of EPA and sesame lignans which we reported in our past study (13). To investigate the effect of dietary AA and sesame lignans on PUFA metabolism in rats, the content of PUFA in the liver was determined and the n-6/n-3 ratio of PUFA was also examined.…”

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confidence: 99%

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The metabolism and n−6/n−3 ratio of essential fatty acids in rats: Effect of dietary arachidonic acid and a mixture of sesame lignans (sesamin and episesamin)

Umeda-Sawada

Ogawa

Igarashi

1998

Lipids

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In this study, we examined the effect of dietary arachidonic acid (AA) and sesame lignans on the content and n-6/n-3 ratio of polyunsaturated fatty acid (PUFA) in rat liver and the concentrations of triglyceride (TG) and ketone bodies in serum. For 4 wk, rats were fed two types of dietary oils: (i) the control oil diet groups (CO and COS): soybean oil/perilla oil = 5:1, and (ii) the AA-rich oil group (AO and AOS): AA ethyl esters/palm oil/perilla oil = 2:2:1, with (COS and AOS) or without (CO and AO) 0.5% (w/w) of sesame lignans. Dietary AA and sesame lignans significantly affected hepatic PUFA metabolism. AA content and n-6/n-3 ratio in the liver were significantly increased in the AO group, despite the dietary total of n-6 PUFA being the same in all groups, while AOS diet reduced AA content and n-6/n-3 ratio to a level similar to the CO and COS groups. These results suggest that (i) dietary AA considerably affects the hepatic profile and n-6/n-3 ratio of PUFA, and (ii) dietary sesame lignans reduce AA content and n-6/n-3 ratio in the liver. In the AO group, the concentration of acetoacetate was significantly increased, but the ratio of beta-hydroxybutyrate/acetoacetate was decreased. On the other hand, the AO diet increased the concentration of TG in serum by almost twofold as compared to other groups. However, the AOS diet significantly reduced serum TG level as compared to the AO group. In addition, the AOS diet significantly increased the acetoacetate level, but reduced the beta-hydroxybutyrate/acetoacetate ratio. These results suggest that dietary sesame lignans promote ketogenesis and reduce PUFA esterification into TG. This study resulted in two findings: (i) sesame lignans inhibited extreme changes of the n-6/n-3 ratio by reducing hepatic PUFA content, and (ii) the reduction of hepatic PUFA content may have occurred because of the effects of sesame lignans on PUFA degradation (oxidation) and esterification.

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Section: Methodssupporting

confidence: 64%

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confidence: 54%

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confidence: 98%

mentioning

confidence: 99%

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The metabolism and n−6/n−3 ratio of essential fatty acids in rats: Effect of dietary arachidonic acid and a mixture of sesame lignans (sesamin and episesamin)

Umeda-Sawada

Ogawa

Igarashi

1998

Lipids

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“…10) We also found that sesamin administered together with an oil rich in EPA increased the content of n-6 fatty acids (especially AA) in rat liver, and decreased that of n-3 fatty acids (especially EPA) there. 10) In this study, we investigated the effect of sesamin on the contents of n-3, n-6, and n-9 fatty acids in rat liver and on the absorption of these fatty acids into the mesenteric lymph.…”

Section: • 8 )mentioning

confidence: 99%

Effect of Sesamin on the Composition of Eicosapentaenoic Acid in Liver and on Its Lymphatic Absorption in Rats

Umeda-Sawada

Ogawa

Okada

et al. 1996

Bioscience, Biotechnology, and Biochemistry

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Phenols in the plant and in man. The potential for possible nutritional enhancement of the diet by modifying the phenols content or profile

Parr

Bolwell

2000

J. Sci. Food Agric.

666

327

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There is growing recognition that many phenolic secondary metabolites present in foodstuffs may possibly exert beneficial effects on human health. This may to some degree be mediated via antioxidant actions, but a range of more specific pharmacological effects have also been proposed. Given this background, there may be favourable consequences for the general health of Western populations as a result of optimising the phenolic content of the diet. This paper reviews what is known of the function of phenolics both in the plant and in man. It also describes current understanding of the biosynthesis of phenolics in plants, with emphasis on where potential controlling steps may exist. Finally, advances in identification and isolation of the genes coding for phenolic biosynthetic enzymes or regulatory proteins are also summarised. Taken together, this information provides a basis for attempts to modify and optimise the phenolic content of food crops, using either conventional plant breeding along with manipulation of agronomic practices, or else the more targeted approaches of modern molecular biology. © 2000 Society of Chemical Industry

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Interaction of Sesamin and Eicosapentaenoic Acid againstΔ5 Desaturation and n-6/ n-3 Ratio of Essential Fatty Acids in Rat

Cited by 22 publications

References 9 publications

The metabolism and n−6/n−3 ratio of essential fatty acids in rats: Effect of dietary arachidonic acid and a mixture of sesame lignans (sesamin and episesamin)

The metabolism and n−6/n−3 ratio of essential fatty acids in rats: Effect of dietary arachidonic acid and a mixture of sesame lignans (sesamin and episesamin)

Effect of Sesamin on the Composition of Eicosapentaenoic Acid in Liver and on Its Lymphatic Absorption in Rats

Phenols in the plant and in man. The potential for possible nutritional enhancement of the diet by modifying the phenols content or profile

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