Interaction of silver nanoparticles with Vancomycin: an UV-vis study

Silymarin (SIL) is a component extracted from Silybum marianum herb and is studied in medicine due to its protective activities on certain organs (liver, kidney, heart, brain). The review discusses some methods that increase silymarin bioavailability such as development of complexes with cyclodextrins, phospholipids, liposome and nanostructured material (hydroxyapatite-HAP). The interactions between SIL and alpha-lipoic acid, metallic nanoparticles (gold nanoparticles-GNP, and silver nanoparticles – SNP), some carotenoids (β-carotene and lycopene) and curcumin were debated too. Some combined treatments (e.g. SIL + curcumin) highlighted anticancer activity against colon cancer cells (DLD-1, HCT116 and LoVo) and protective effect against chemicals toxicity.

Section: Silymarin Interaction With Metallic Nanoparticlesmentioning

confidence: 99%

Silymarin Based Complexes – a mini review

PALTINEAN¹,

Tomoaia²,

Riga³

et al. 2022

“…Their size is around 35 ± 5 nm. These nanoparticles have antimicrobial effects on Escherichia coli bacteria [115,116].…”

Section: Characterization Of Silver Naoparticlesmentioning

confidence: 99%

Biomimetic and Antibacterial Composite for Orthopedic Implants

Balint¹,

Paltinean²,

FLOREA³

et al. 2022

Self Cite

The present paper shows how the development of synthetic nanostructured biomaterials, such as multisubstituted hydroxyapatite (msHAP) with Mg2+, Zn2+ and Sr2+ ions is important and beneficial at the same time for the normal functioning of the body. Moreover, the paper discusses a broad topic of major importance in orthopedic and dental surgery, namely the incorporation of msHAP into the polymeric matrix of poly lactic acid (PLA). This composite is used in order to cover the surface of the titanium implant in order to obtain bone integration and heal bone fractures. The review also highlights the importance of improving silver nanoparticle (SNPs) coating in order to combat postoperative infections. Through such approaches, medicine has managed to evolve considerably, and the contributions brought by great personalities and young researchers in the field have increased its area of applicability.

“…Eventually the functional imbalance of the bacterium occurs and death is caused [121,122]. In the fight against pathogens is very important the method of preparing nanoparticles and the use of reducing and coating agents that can influence the interactions between the drug and silver and can determine the size and shape [92,[123][124][125][126]. Silver nanoparticles can be synthetized by chemical and biological methods, the most known being reduction of silver nitrate (AgNO3) with a large variety of reducing agents such as sodium citrate [123,127,128], sodium borohydride [129], glucose [130,131], gallic acid, ascorbic acid and plant extract [92,132] but also by electrochemical or photochemical methods.…”

Section: Example Of Metallic Biomaterialsmentioning

confidence: 99%

“…The exploitation of SNPs has intensified in recent years due to the invasion of pathogens in the health system and the resistance of bacteria to antibiotics. In this sense, there are experimental studies that highlight the effectiveness of SNPs functionalized with vancomycin and other antibiotics potentiating their effect on bacterial strains [124,134].…”

Section: Example Of Metallic Biomaterialsmentioning

confidence: 99%

Biomaterials With Enhanced Biological Functions for Medical Applications

Balint¹,

Paltinean²,

Tomoaia³

et al. 2021

Self Cite

Biomaterials and their use as implant coatings have been evaluated focusing on biocompatibility, biodegradability and constructive responses in terms of osseointegration, cell proliferation and cell adhesion. Biomaterials from natural (protein and polysaccharide) and synthetic (metallic, polymeric, ceramic and composite) sources have been identified. The role of biomaterials and implant coatings in the body through in vivo and in vitro experiments has been highlighted. In addition, methods for activating the surface of implants such as mechanical, chemical and physical ones are presented, as well as the classification of the deposition procedures but also of the interactions with the living system. This review addresses a topic with future challenges and perspectives in the biomedical field with the well-defined goal of maintaining and enhancing tissue elasticity, facilitating the healing of diseases suffered by patients and developing innovative materials capable of replacing or regenerating affected tissues.