Interaction of zinc with antidepressants in the tail suspension test

Cunha, Maurício P.; Machado, Daniele G.; Bettio, Luis E.B.; Capra, Juliano C.; Rodrigues, Ana Lúcia S.

doi:10.1016/j.pnpbp.2008.09.006

Cited by 124 publications

(86 citation statements)

References 60 publications

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“…The authors also observed an increase in the swimming, but not climbing parameter of the rat FST after zinc administration, which indicates involvement of the serotonin pathway [56]. Moreover, joint administration of zinc and fluoxetine, paroxetine, citalopram or bupropion (all in ineffective doses), yet not reboxetine, significantly decreased the immobility time in the FST and TST [10,56]. Furthermore, there is strong evidence also suggesting the involvement of the dopaminergic system in the antidepressant properties of zinc.…”

Section: Zinc Deficiency Alters Responsiveness To Antidepressantsmentioning

confidence: 87%

“…There is some evidence coming from preclinical and clinical studies suggesting a relationship between dietary zinc intake and depressive symptoms [5,29,64,68,69]. Zinc shows antidepressant-like properties in preclinical test and models [6,10,20,21,36,42,52]. Recently, there has been emerging evidence that zinc deficiency can induce depressive-like behavior in mice [30,31,69] and rats [57,64,67].…”

Section: Introductionmentioning

confidence: 99%

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Zinc deficiency alters responsiveness to antidepressant drugs in mice

Młyniec

Budziszewska

Reczyński

et al. 2013

Pharmacological Reports

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Abstract:Background: There is some evidence coming from preclinical and clinical studies suggesting a relationship between dietary zinc intake and depressive symptoms. The aim of the study was to determine whether zinc deficiency alters the response to antidepressants with a different mechanism of action. We examine also whether these changes are related to activity of the hypothalamic-pituitaryadrenal HPA axis. Methods: Male CD-1 mice were assigned to groups according to diet and antidepressant administration. To evaluate animal behavior, the immobility time in the forced swim test (FST) and locomotor activity were measured. To determine serum zinc levels the flame atomic absorption spectroscopy (FAAS) was used. The serum corticosterone was determined by radioimmunoassay (RIA). Results: Antidepressants administered to zinc-deprived mice induced an altered response in the FST when compared to animals fed with an adequate diet. There were no changes in locomotor activity. Animals subjected to a zinc-deficient diet showed a significant reduction in serum zinc levels, which was normalized by antidepressant treatment. An increase in serum corticosterone concentrations in mice fed with a zinc-deficient diet and treated with antidepressants was observed, so it can be concluded that reduced levels of zinc contribute hyperactivation of the HPA axis. Conclusion:The results of this study suggest that a diet with a reduced zinc level alters antidepressant action, which is associated with a reduction in the serum zinc level and rise in the corticosterone level. The results of this study may indicate the involvement of zinc deficiency in the pathogenesis of depression.

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Section: Zinc Deficiency Alters Responsiveness To Antidepressantsmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Zinc deficiency alters responsiveness to antidepressant drugs in mice

Młyniec

Budziszewska

Reczyński

et al. 2013

Pharmacological Reports

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“…The doses of antidepressant compounds (creatine, ketamine, and fluoxetine) used were selected based on previous results from our laboratory [16,39,40].…”

Section: Experimental Designmentioning

confidence: 99%

“…Immobility time was recorded during a 6-min period. Mice were considered immobile only when they hung passively and completely motionless [16,39,42].…”

Section: Tail Suspension Test (Tst)mentioning

confidence: 99%

Creatine, similarly to ketamine, affords antidepressant-like effects in the tail suspension test via adenosine A1 and A2A receptor activation

Cunha

Pazini

Rosa

et al. 2015

Purinergic Signalling

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The benefits of creatine supplementation have been reported in a broad range of central nervous systems diseases, including depression. A previous study from our group demonstrated that creatine produces an antidepressant-like effect in the tail suspension test (TST), a predictive model of antidepressant activity. Since depression is associated with a dysfunction of the adenosinergic system, we investigated the involvement of adenosine A 1 and A 2A receptors in the antidepressant-like effect of creatine in the TST. The anti-immobility effect of creatine (1 mg/kg, po) or ketamine (a fast-acting antidepressant, 1 mg/kg, ip) in the TST was prevented by pretreatment of mice with caffeine (3 mg/kg, ip, nonselective adenosine receptor antagonist), 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) (2 mg/kg, ip, selective adenosine A 1 receptor antagonist), and 4-(2-[7-amino-2-{2-furyl}{1,2,4}triazolo-{2,3-a}{1,3,5}triazin-5-ylamino]ethyl)-phenol (ZM241385) (1 mg/kg, ip, selective adenosine A 2A receptor antagonist). In addition, the combined administration of subeffective doses of creatine and adenosine (0.1 mg/kg, ip, nonselective adenosine receptor agonist) or inosine (0.1 mg/kg, ip, nucleoside formed by the breakdown of adenosine) reduced immobility time in the TST. Moreover, the administration of subeffective doses of creatine or ketamine combined with N-6-cyclohexyladenosine (CHA) (0.05 mg/kg, ip, selective adenosine A 1 receptor agonist), N-6-[2-(3,5-dimethoxyphenyl)-2-(methylphenyl)ethyl]adenosine (DPMA) (0.1 mg/kg, ip, selective adenosine A 2A receptor agonist), or dipyridamole (0.1 μg/mouse, icv, adenosine transporter inhibitor) produced a synergistic antidepressant-like effect in the TST. These results indicate that creatine, similarly to ketamine, exhibits antidepressant-like effect in the TST probably mediated by the activation of both adenosine A 1 and A 2A receptors, further reinforcing the potential of targeting the purinergic system to the management of mood disorders.

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“…Mice were considered immobile only when they hung passively or stay completely Bakr et al 59 motionless. Conventional antidepressants decrease the immobility time in this test (Cunha et al, 2008;Steru et al, 1985).…”

Section: Tail Suspension Test (Tst)mentioning

confidence: 87%

Phytochemical and biological investigation of Eugenia uniflora L. cultivated in Egypt

Bakr¹,

Mohamed²,

Waly³

2017

J. Pharmacognosy Phytother.

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Eugenia uniflora L. (Myrtaceae) is a plant species used in folk medicine for treatment of various disorders. This study aims to quantify the phenolic and flavonoid contents of E. uniflora aqueous methanolic extract (AME), identification of its major constituents, as well as the evaluation of its biological activity. Quantification was performed using colorimetric assays. Column chromatographic separation was used for isolation of the major phenolic constituents while their structures were elucidated by 1D-and 2D Nuclear magnetic resonance spectroscopy (NMR) spectra. Alkaloids were identified using gas chromatography-mass spectrometry (GC-MS) analysis. The antidepressant activity of E. uniflora AME in mice was evaluated using the tail suspension test (TST). The weight control effect was evaluated by serial weighing. The results showed high phenolic and flavonoid contents of E. uniflora AME. The chromatographic investigation identified a new flavonoid, myricetin 3-O-(4'', 6''-digalloyl) glucopyranoside, for first time in this genus, along with four flavonoids and phenolic acids. Integerrimine alkaloid was identified through GC/MS analysis. Administration of E. uniflora AME significantly reduced the immobility time in mice (P value of < 0.0001) in a dose-dependent manner for doses of 1, 10, 50 and 100 mg/kg. Also, a non-significant weight reduction in mice chronically treated with the E. uniflora AME was observed. Our study reports the isolation of myricetin 3-O-(4'', 6''-digalloyl) glucopyranoside from E. uniflora. It confirms that E. uniflora leaf extract has an antidepressant and anti-obesity effect.

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Interaction of zinc with antidepressants in the tail suspension test

Cited by 124 publications

References 60 publications

Zinc deficiency alters responsiveness to antidepressant drugs in mice

Zinc deficiency alters responsiveness to antidepressant drugs in mice

Creatine, similarly to ketamine, affords antidepressant-like effects in the tail suspension test via adenosine A1 and A2A receptor activation

Phytochemical and biological investigation of Eugenia uniflora L. cultivated in Egypt

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