Interaction study of fenoldopam ? digoxin in congestive heart failure

Abstract

The potential interaction between fenoldopam, a DA1 selective agonist, and digoxin has been studied in 10 patients with heart failure (NYHA Class II or III) on chronic digoxin treatment. Plasma levels and urinary recovery of the glycoside were monitored for 24 h before and after 9 days of treatment with fenoldopam 100 mg tid. Fenoldopam caused a small, non-significant decrease in the mean steady state plasma concentration and area under the plasma concentration curve of digoxin. As the clearance of digoxin was unchanged there does not appear to be an interaction between fenoldopam and digoxin at the level of the renal tubule.

Fenoldopam — A Selective Peripheral Dopamine-Receptor Agonist for the Treatment of Severe Hypertension

“…In 10 patients with congestive heart failure who were taking digoxin, oral fenoldopam did not alter the plasma digoxin concentration. 79 The poor oral bioavailability of fenoldopam, however, detracts from the conclusiveness of this study.…”

Fenoldopam: novo antihipertensivo parenteral; alternativa ao nitroprussiato

“…Differences in potassium serum levels in the fenoldopan group were not clinically relevant 37 . In ten congestive heart failure patients submitted to treatment with digoxin and receiving 100 mg oral fenoldopan every 8 hours for 9 days, there were no significant changes in digoxine's pharmacokinetic properties 38 . An increase in renal plasma flow induced by fenoldopan has been described after the simultaneous administration of intravenous alopurinol.…”

“…As diferenças nos níveis séricos de potássio observados com fenoldopam não foram clinicamente relevantes 37 . Em 10 pacientes portadores de insuficiência cardíaca congestiva submetidos a tratamento com digoxina, e que receberam nove dias de tratamento oral com fenoldopam 100 mg, cada 8 horas, não se evidenciou alteração significativa das propriedades farmacocinéticas da digoxina 38 . Foi descrita atenuação do aumento do fluxo plasmático renal induzido pelo fenoldopam após a administração concomitante de alopurinol venoso.…”