Interactions and functions of the adenomatous polyposis coli (APC) protein at a glance

AXIN2 Polymorphisms, the β-Catenin Destruction Complex Expression Profile and Breast Cancer Susceptibility

“…We found downregulated APC expression in breast cancer patients with advance-stage and larger size tumors. A plausible explication could be the tumor suppressor role of APC, which acts as a negative regulator of the Wnt pathway and other non-Wnt related functions (Nelson and Nathke, 2013). The GSK3β was down-regulated in larger size tumors subgroup.…”

Genomic profiling of stage II and III colon cancers reveals APC mutations to be associated with survival in stage III colon cancer patients

“…The role of APC herein is less established, although some studies have described that loss of APC function was associated with aneuploidy [19–21, 36, 37]. While the mechanism of APC involvement in chromosomal instability remains not fully understood, it has been reported that APC can regulate kinetochore microtubule attachment during mitosis [38, 39]. Inactivated APC may disrupt chromosome segregation followed by an increase in mitotic abnormalities associated with chromosomal instability [18, 36, 38].…”

Canonical and noncanonical Wnt signaling in neural stem/progenitor cells

“…Conditional knockout of APC in GFAP-expressing cells of mice activates β-catenin, reduces neurogenesis and impairs neuronal differentiation [134]. However, it is worth noting that while LiCl and APC gene deletion both activate β-catenin signaling, these treatments have unrelated β-catenin-independent effects [135][136][137][138]. APC, for example, also plays a role in neuronal migration by binding the 3′ UTR of β2B-tubulin mRNA [139].…”