Interactions between adiponectin, visfatin, and omentin in subcutaneous and visceral adipose tissues and serum, and correlations with clinical and peripheral metabolic factors

The levels of visceral adipose tissue-derived serpin, omentin-1 and tumor necrosis factor-α in the gingival crevicular fluid of obese patients following periodontal therapy

“…This supports our finding that omentin is negatively influenced by inflammatory processes. In agreement with our findings, it was also reported that omentin negatively correlated with BMI, TNF-α and WC (19,51).…”

Circulating omentin-1 might be associated with metabolic health status in different phenotypes of body size

“…The underlying mechanisms linking obesity and adipose tissue dysfunction to metabolic disorders are not well known (12). It has recently been suggested that the relationship between different obesity phenotypes and susceptibility to subsequent complications might be mediated by adipose tissue metabolic changes (13) such as dysregulated production of adipokines (14).…”

Correlations between the expression of the insulin sensitizing hormones, adiponectin, visfatin, and omentin, and the appetite regulatory hormone, neuropeptide Y and its receptors in subcutaneous and visceral adipose tissues

“…First, in subcutaneous adipose tissue, the expression of adiponectin, visfatin, and omentin were positively correlated with the expression of NPY and NPY receptors. and not with subcutaneous adipocytes, suggesting that larger visceral adipocytes, but not subcutaneous adipocytes, associated with increased insulin resistance and decreased insulin sensitivity [22]. Moreover, our data from a previous study demonstrated that Y1R in visceral adipose tissue showed positive correlations with plasma insulin levels and HOMA-IR, suggesting that visceral, not subcutaneous, Y1R expression was associated with insulin resistance [15].…”

“…Moreover, our data from a previous study demonstrated that Y1R in visceral adipose tissue showed positive correlations with plasma insulin levels and HOMA-IR, suggesting that visceral, not subcutaneous, Y1R expression was associated with insulin resistance [15]. Furthermore, our previous study demonstrated that the subcutaneous expression of adiponectin and omentin showed positive associations with QUICKI, suggesting that subcutaneous adipose tissue gene expression associated with insulin sensitivity [22]. These results implied that the regulation of gene expressions was different between subcutaneous and visceral adipose tissues.…”

“…NPY mRNA expression has previously been found to be higher in obese than in normal weight humans in both subcutaneous and visceral adipose tissues and was higher in visceral than in subcutaneous adipose tissues [15]. In contrast, visfatin expression was found to be similar between obese and non-obese humans with similar expression between subcutaneous and visceral adipose tissues [22]. These observations could not be explained from the aspect of cause/effect/association; hence, the underlying mechanism needs to be further investigated.…”