Interactions Between Cadmium and Zinc in the Biological Samples of Pakistani Smokers and Nonsmokers Cardiovascular Disease Patients

Afridi, Hassan Imran; Kazi, Tasneem Gul; Kazi, Naveed; Kandhro, Ghulam Abbas; Baig, Jameel Ahmed; Jamali, Mohammad Khan; Arain, Mohammad Balal; Shah, Abdul Qadir

doi:10.1007/s12011-009-8607-3

Cited by 27 publications

(6 citation statements)

References 38 publications

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“…Low serum zinc/24-hour urine zinc ratio is associated with angiographically severe atherosclerosis. It was observed that low zinc levels were associated with patients with cardiovascular diseases (1,6).…”

Section: Discussionmentioning

confidence: 99%

Iron concentrations in atherosclerotic plaque and serum in patients with carotid atherosclerosis

Tasić¹,

Tasić²,

Veselinović³

et al. 2015

Acta Physiologica Hungarica

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The aim of this study was to investigate the iron concentrations in serum and carotid plaque in patients with different morphology of carotid atherosclerotic plaque and compared with other metal ions. Carotid endarterectomy due to the significant atherosclerotic stenosis was performed in 91 patients. Control group consisted of 27 patients, without carotid atherosclerosis. Atherosclerotic plaques were divided into four morphological groups, according to ultrasonic and intraoperative characteristics. Iron, copper and zinc concentration in plaque, carotid artery and serum were measured by spectrophotometry. Serum iron concentrations were higher in patients with hemorrhagic plaques in comparison to the control group (4.7 μmol/l ± 1.2 vs. 2.1 μmol/l ± 0.8, p < 0.05). Iron concentrations were higher in patients with hemorrhagic plaques in comparison to fibrolipid plaques (72.1 ± 14.3 μg/g vs. 39.3 ± 22.9 μg/g; p < 0.05). Negative significant correlation was found for zinc in serum and plaque iron concentration in patients (p < 0.05). We also demonstrated positive significant correlation for copper and iron in serum (p < 0.05). The data obtained in the current study are consistent with the hypothesis that high iron levels may contribute to atherosclerosis and its complications as factors in a multifactorial disease.Keywords: carotid plaque, atherosclerosis, iron, zinc, copperOver the last 30 years, several studies in animals and humans assessed the effect of increased body iron levels on atherosclerosis, yielding conflicting results.Iron is a key element in many biochemical processes and shortage of iron causes damage to cells and organs. On the other hand, excess iron could be harmful because it is able to catalyse the formation of highly reactive oxygen and hydrogen radicals when present in the unbound state. Transition metal ions, established catalysts of protein, lipid and DNA oxidation, are present at elevated levels in human atherosclerotic plaques, and in some animal models, consistent with the hypothesis that metal ions contribute to both plaque formation and its destabilization (19,21,23), though the role of metal ions remains controversial (16,29).Epidemiological studies have reported an increased incidence of cardiovascular disease (CVD) in subjects with overt iron overload (7,8,19). Recent studies on cardiovascular evaluation and outcome in high-versus low-frequency blood donors have demonstrated improvements in surrogate markers of vascular health such as decreased oxidative stress, and

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Section: Discussionmentioning

confidence: 99%

Iron concentrations in atherosclerotic plaque and serum in patients with carotid atherosclerosis

Tasić¹,

Tasić²,

Veselinović³

et al. 2015

Acta Physiologica Hungarica

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“…For digestion of biological samples, duplicate samples of whole blood samples (0. A blank acid digestion (without samples/standards) was carried out through the complete procedure [32].…”

Section: Microwave Induced Acid Digestion Methodsmentioning

confidence: 99%

Evaluation of Essential and Toxic Elements in Blood Samples of Male Smokers Having Different Types of Cancers with Reference to Healthy Male Smokers

Kazi¹

2016

J. Clinical Medi. Res. Updates

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Immense epidemiologic studies have been reported about the role of essential trace and toxic elements as risk factors for incidence of different type of cancers in population of developed and developing countries. In present work the levels of carcinogenic, Arsenic, Cadmium, and Nickel (As, Cd and Ni) and anti-carcinogenic, Zinc and Selenium (Zn and Se) elements were measured in blood of male cancer patients (urinary bladder, lung, mouth and esophageal) and healthy referents. The all patients and referents were smoker. The blood samples were analysed with atomic absorption spectrometry after microwave assisted acid digestion. The resulted data indicated that the levels of toxic elements As, Ni and Cd were considerably elevated whereas essential elements, Zn and Se were lower in blood samples of all cancer cases as compared to those values found in noncancerous subjects. As the levels of essential trace elements were low in blood samples of male cancerous patients but difference was highly significant in lung and mouth cancer subjects (p<0.001), whereas sequence of decreasing order was not uniform. The levels of Zn in blood samples of different cancerous patients were found in decreasing order as: esophagus< mouth< urinary bladder

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“…Heavy metals exposure up to different levels might cause various behavioral and morphological aberrations in fish (Qadir and Malik, 2011). Cd is considered as a toxic heavy metal and also have disrupting properties of endocrine (Afridi et al, 2011;Chouchene et al, 2011). Some metals like Cd, Cr, Pb, Hg and As being non-essential elements can exert toxic effects even at very low concentration.…”

Section: Biochemical Toxicitymentioning

confidence: 99%

A Review on Histopathological Alterations Induced by Heavy Metals (Cd, Ni, Cr, Hg) in Different Fish Species

Bibi¹,

Naz²,

Saeed³

et al. 2021

PUJZ

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Industrial, domestic and other human activities are responsible for heavy metal toxicity of aquatic bodies. Metals are the major stimulators for variety of diseases in aquatic organisms mainly fishes. Chromium (Cr), mercury (Hg), nickel (Ni) and cadmium (Cd) causes histopathological variations and several diseases in various fishes of Pakistan. Extensive histopathological variations in gills, liver, kidney and skin of different fishes were noticed when exposed to heavy metals, thus indicating severity of heavy metal toxicity. The current study was focused on the toxicological effect of Cr, Hg, Ni and Cd in different type of fishes and it would be useful for the scientific community to restore different metals contaminating water.Novelty Statement | Histopathological alterations in target fish organs functioned as fundamental indicator to assess metal toxicity in different fish species as it provides accurate data on effects of different contami-nants on fish. Hence, histopathology must be consider to monitor contaminated aquatic systems.

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Interactions Between Cadmium and Zinc in the Biological Samples of Pakistani Smokers and Nonsmokers Cardiovascular Disease Patients

Cited by 27 publications

References 38 publications

Iron concentrations in atherosclerotic plaque and serum in patients with carotid atherosclerosis

Iron concentrations in atherosclerotic plaque and serum in patients with carotid atherosclerosis

Evaluation of Essential and Toxic Elements in Blood Samples of Male Smokers Having Different Types of Cancers with Reference to Healthy Male Smokers

A Review on Histopathological Alterations Induced by Heavy Metals (Cd, Ni, Cr, Hg) in Different Fish Species

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