Interactions between cigarette smoking and XPC-PAT genetic polymorphism enhance bladder cancer risk

Liu, Yang; Wang, Huanhuan; Lin, Tianxin; Wei, Quanfang; Zhi, Yi; Yuan, Fang; Song, Bo; Yang, Jin; Chen, Zhiwen

doi:10.3892/or.2012.1759

Cited by 9 publications

(8 citation statements)

References 30 publications

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“…All studies included in the present meta-analysis used a case–control design. Finally, 12 studies were identified for eligibility and were included in our meta-analysis, with a total of 4,828 cancer cases and 4,890 controls [8-19] (Table 1). All patients in cases groups were histologically or pathologically confirmed, and controls were mainly matched by age, sex and ethnicity.…”

Section: Resultsmentioning

confidence: 99%

The association between XPC Lys939Gln gene polymorphism and urinary bladder cancer susceptibility: a systematic review and meta-analysis

Dou

Han

2013

Diagn Pathol

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BackgroundNumerous epidemiological studies have been conducted to explore the association between the Lys939Gln polymorphism of Xeroderma pigmentosum group C (XPC) gene and urinary bladder cancer susceptibility. However, the results remain inconclusive. In order to derive a more precise estimation of this relationship, a large and update meta-analysis was performed in this study.MethodsA comprehensive search was conducted through researching MEDLINE, EMBASE, PubMed, Web of Science, China Biomedical Literature database (CBM) and China National Knowledge Infrastructure (CNKI) databases before June 2013. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of the association.ResultsA total of 12 studies with 4828 cases and 4890 controls for evaluating the XPC Lys939Gln polymorphism and urinary bladder cancer were included. Overall, there was significant associations between the XPC Lys939Gln polymorphism and urinary bladder cancer risk were found for homozygous model (OR = 1.352, 95% CL = 1.088-1.681), heterozygous model (OR = 1.354, 95% CL = 1.085-1.688), and allele comparison (OR = 1.109, 95% CL = 1.013-1.214). In subgroup analysis by ethnicity and source of controls, there were still significant associations detected in some genetic models.ConclusionOur meta-analysis suggested that the XPC Lys939Gln polymorphism contributed to the risk of urinary bladder cancer.Virtual slidesThe virtual slide(s) for this article can be found here: .

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Section: Resultsmentioning

confidence: 99%

The association between XPC Lys939Gln gene polymorphism and urinary bladder cancer susceptibility: a systematic review and meta-analysis

Dou

Han

2013

Diagn Pathol

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“…Single locus analysis revealed a strong association of Ala499Val substitution with UBC risk, supporting the previous findings on the various ethnic populations 6 10 . Nevertheless, a few studies have reported that Ala499Val substitution is not related to UBC risk 13 17 18 20 . We pooled all eligible studies to perform meta-analyses, which suggested a significant association of Ala499Val substitution with increased UBC risk.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have reported inconsistent results about the association between these polymorphisms and UBC45681011121314151617181920. The inconsistencies between these studies indicate that the association of XPC polymorphisms with UBC risk may depend on the type of population as well as the environmental factors and host characteristics.…”

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confidence: 99%

Polymorphisms in the XPC gene affect urinary bladder cancer risk: a case-control study, meta-analyses and trial sequential analyses

Sankhwar

Gupta

et al. 2016

Sci Rep

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Compromised activity of the DNA repair enzymes may raise the risk of a number of cancers. We analyzed polymorphisms in the Xeroderma Pigmentosum, Complementation Group C (XPC) gene for their correlation with urinary bladder cancer. Ala499Val and Lys939Gln polymorphisms were genotyped in 234 urinary bladder cancer cases and 258 control samples. A significant association between Ala499Val polymorphism and bladder cancer was observed (OR = 1.78, CI = 1.19–2.66, p = 0.005); however, Lys939Gln was unrelated (OR = 0.97, CI = 0.65–1.45, P = 0.89). Further analysis revealed that Ala499Val was a significant risk factor only in the presence of smoking (OR = 2.23, CI = 1.28–3.87, p < 0.004) or tobacco chewing (OR = 2.40, CI = 1.43–4.04, p = 0.0008). To further appraise the association, we undertook meta-analyses on seven studies (2893 cases and 3056 controls) on Ala499Val polymorphism and eleven studies (5064 cases and 5208 controls) on Lys939Gln polymorphism. Meta-analyses corroborated the above results, showing strong association of Ala499Val (OR = 1.54, CI = 1.21–1.97, p = 0.001) but not that of Lys939Gln (OR = 1.13, CI = 0.95–1.34, p = 0.171) with urinary bladder cancer risk. In conclusion, XPC Ala499Val substitution increases urinary bladder cancer risk, but Lys939Gln appears to be neutral.

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“…Recently, some studies focused on the association between VEGF gene polymorphisms and bladder cancer risks were conducted, but these studies concluded inconsistent results. Several large cohort studies in Europe and the USA have demonstrated that cigarette smoking was an important risk factor for bladder cancer [11, 12], and several genes have been reported interaction with smoking on bladder cancer susceptibility, such as XPC-PAT gene [13], however, no study focused on impact of interaction between VEGF gene and smoking on bladder cancer risk. So the present study aimed to evaluate the influence of VEGF SNPs, possible gene- gene, gene- smoking interaction and haplotype combinations on bladder cancer risk base on a Chinese population.…”

Section: Introductionmentioning

confidence: 99%

Impact of vascular endothelial growth factor gene-gene and gene-smoking interaction and haplotype combination on bladder cancer risk in Chinese population

Cheng

et al. 2017

Oncotarget

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AimsTo investigate the association of single nucleotide polymorphisms (SNPs) within vascular endothelial growth factor (VEGF) gene polymorphisms, additional gene- gene and gene- smoking interactions with bladder cancer risk.ResultsBladder cancer risk was significantly higher in carriers of the rs699947- A allele within VEGF gene than those with rs699947- CC genotype (CA+ AA versus CC), adjusted OR (95%CI) = 1.70 (1.16–2.31), and higher in carriers of the rs833052- A allele of within VEGF gene than those with rs833052- CC genotype (CA+ AA versus CC), adjusted OR (95%CI) = 1.65 (1.23–2.12). GMDR analysis indicated a potential interaction between rs2010963 and smoking on bladder cancer risk. Current smokers with rs2010963- GC+CC genotype within VEGF gene have the highest bladder cancer risk, compared to never smokers with rs2010963- GG genotype within VEGF gene, OR (95%CI) = 3.25 (1.71–4.83). Haplotype containing the rs2010963- C and rs833052- A alleles were associated with a statistically increased bladder cancer risk, OR (95%CI) = 2.21 (1.12–3.42).Materials and MethodsGeneralized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among SNPs and smoking. Logistic regression was performed to investigate association of 6 SNPs within VEGF gene, additional gene- gene and gene- smoking interaction with bladder cancer risk.ConclusionsWe found that the A allele of rs699947 and the A allele of rs833052 within VEGF gene, interaction between rs2010963 and smoking, haplotype containing the rs2010963- C and rs833052- A alleles were all associated with increased bladder cancer risk.

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Interactions between cigarette smoking and XPC-PAT genetic polymorphism enhance bladder cancer risk

Cited by 9 publications

References 30 publications

The association between XPC Lys939Gln gene polymorphism and urinary bladder cancer susceptibility: a systematic review and meta-analysis

The association between XPC Lys939Gln gene polymorphism and urinary bladder cancer susceptibility: a systematic review and meta-analysis

Polymorphisms in the XPC gene affect urinary bladder cancer risk: a case-control study, meta-analyses and trial sequential analyses

Impact of vascular endothelial growth factor gene-gene and gene-smoking interaction and haplotype combination on bladder cancer risk in Chinese population

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