“…The practical and economic feasibility of the approach, together with the favorable dissolution performance of the incorporated API, has attracted great interest within the pharmaceutical industry (Kanaujia et al, 2011;Li et al, 2014;Tian et al, 2013). In order to successfully extrude polymer-based amorphous dispersions, the extrusion temperature is typically set 30 to 60 o C higher than the T g (glass transition temperature) or T m (melting temperature) of the polymer to ensure good flowability of the mixture during the extrusion process (Chokshi et al, 2005;Li et al, 2014;McGinity et al, 2006). However, given that the choice of a high T g polymer is often preferred due to the physical stabilisation of the amorphous solid dispersions (Hancock and Zografi, 1997;Sathigari et al, 2012;Shah et al, 2013), the T g of many pharmaceutically acceptable polymers may be too high for the extrusion process for reasons of cost or heat-induced degradation; hence, a more moderate working temperature is required and there is therefore a balance between stabilization of the system and feasibility of manufacture.…”