No abstract

In an effort to develop antimicrobial agents, a series of chalcones were prepared by Claisen-Schmidt condensation of appropriate acetophenones with appropriate aromatic aldehydes in the presence of aqueous solution of potassium hydroxide and ethanol at room temperature. The synthesized compounds were characterized by means of their IR,1H-NMR spectral data and elemental analysis. All the compounds were tested for their antibacterial and antifungal activities by the cup plate method.

Pyrazole derivatives R 0180Synthesis and Antidepressant Activity of Some 1,3,5-Triphenyl-2-pyrazolines and 3-(2''-Hydroxynaphthalen-1''-yl)-1,5-diphenyl-2-pyrazolines. -Compounds (V) and (IX) show the highest antidepressant activity of all compounds tested. -(PRASAD*, Y. R.; RAO, A. L.; PRASOONA, L.; MURALI, K.; KUMAR, P. R.; Bioorg. Med. Chem. Lett. 15 (2005) 22, 5030-5034; Univ. Coll. Pharm. Sci., Andhra Univ., Visakhapatnam 530 003, India; Eng.) -C. Oppel

Five novel chalcones were synthesised by condensing 2-hydroxy-1-acetonaphthone with aldehyde derivatives in dilute ethanolic potassium hydroxide solution at room temperature according to Claisen-Schmidt condensation and another five novel chalcones were prepared by refluxing 3-acetyl coumarin with aldehydes in the presence of piperidine in ethanol. All these compounds were characterised by means of their IR,1H NMR spectroscopic data and microanalyses. The antimicrobial activity of these compounds were evaluated by the cup plate method.

Six new chalcones were synthesised by condensing 2-acetyl pyridine with aldehyde derivatives in dilute ethanolic potassium hydroxide solution at room temperature according to Claisen-Schmidt condensation. All these compounds were characterised by means of their IR,1H NMR spectroscopic data and microanalyses. The antimicrobial activity of these compounds was evaluated by the cup plate method.