Synthesis and Antimicrobial Activity of Some New Chalcones of 2‐Acetyl Pyridine

Abstract

Six new chalcones were synthesised by condensing 2-acetyl pyridine with aldehyde derivatives in dilute ethanolic potassium hydroxide solution at room temperature according to Claisen-Schmidt condensation. All these compounds were characterised by means of their IR,1H NMR spectroscopic data and microanalyses. The antimicrobial activity of these compounds was evaluated by the cup plate method.

Synthesis and Spectroscopic Characterization of Some New Biological Active Azo–Pyrazoline Derivatives

“…Azo compounds are important as synthetic dyes [5,6] and cosmetics [7] . Chalcones and azo-chalcones are useful precursor for the synthesis of different heterocyclic compounds like pyrimidines [8] , thiazepines [9] and anti-malarial [13] , anti-bacterial [14] , anti-oxidative [15] , anti-fungal [16] , anti-leishmanial [17] , anti-tumour [18] , central nervous system [19] , anti-histaminic [20] . Herein , we have described the synthesis of some new azo-pyrazoline compounds derived from 2-chloro aniline and phydroxy acetophenone with evaluation their anti bacterial studies.…”

Inhibitory activity of Dodonaea viscosa var. angustifolia extract against Streptococcus mutans and its biofilm

“…This may have reduced the adherence of S. mutans to glass surfaces. Chalcones which were detected in this plant also have antibacterial properties (Rajendra Prasad et al, 2008). Although tannins have antibacterial properties, 4-O-b-Dxylopyranoside has a weaker antibacterial effect on gram-positive bacteria (Fogliani et al, 2005).…”

Solvent Free Synthesis of Chalcone as Antibacterial Substance

“…Beberapa senyawa calkon yang berhasil diisolasi menunjukkan aktivitas biologis yang sangat bermanfaat, antara lain sebagai antitumor, antiinflamasi, antimikroba dan tabir surya (Achanta et al, 2006;Kim et al, 2007;Kim et al, 2008;Prasad et al, 2008). Begitu pula Jasril et al, (2012) berhasil mensintesis senyawa bromocalkonpiridin dan menunjukkan aktivitasnya sebagai antibakteri.…”