Synthesis and Antidepressant Activity of Some 1,3,5‐Triphenyl‐2‐pyrazolines and 3‐(2′′‐Hydroxynaphthalen‐1′′‐yl)‐1,5‐diphenyl‐2‐pyrazolines.

Abstract

Pyrazole derivatives R 0180Synthesis and Antidepressant Activity of Some 1,3,5-Triphenyl-2-pyrazolines and 3-(2''-Hydroxynaphthalen-1''-yl)-1,5-diphenyl-2-pyrazolines. -Compounds (V) and (IX) show the highest antidepressant activity of all compounds tested. -(PRASAD*, Y. R.; RAO, A. L.; PRASOONA, L.; MURALI, K.; KUMAR, P. R.; Bioorg. Med. Chem. Lett. 15 (2005) 22, 5030-5034; Univ. Coll. Pharm. Sci., Andhra Univ., Visakhapatnam 530 003, India; Eng.) -C. Oppel

Synthesis and studies on antidepressant activity of 2′,4′,6′-trihydroxychalcone derivatives

“…Compound 1 (1-(2-hydroxy-4,6-bismethoxymethoxy-phenyl)-ethanone was prepared as reported previously (Raiendra Prasad et al, 2005). Intermediates 2a-q was prepared by Claisen-Schmidt condensation of 1 with appropriate aromatic aldehydes or hydroxyaromatic aldehydes, protected as chloromethyl methyl ether (Raiendra Prasad et al, 2005;Zhao et al, 2005;Nishida et al, 2007). Then intermediates 2a-q were treated with 3 M HCl in methanol to yield the hydroxychalcones 3a-q in good yield.…”

Pyrazolines With Anticonvulsant and Mao Inhibitory Activities

“…The antidepressant activities of the synthesized compounds were evaluated by the 'Porsolt Behavioural Despair Test' where compound 12 showed the best activity and reduced immobility time by 48.62 % at 100 mg kg −1 (Palaska 2001 Cl 12 Further 1,3,5-tri-substituted 2-pyrazolines have been introduced by Prasad et al Therefore, series of 3-(2-Naphthalen-1-yl)-1,5-diphenyl-2-pyrazolines has been prepared and evaluated by the Porsolt behavioural despair test. Compound 13 was the most active candidate showing 54.10 % reduction in the immobility time at 100 mg/kg (Prasad 2005). (14) and 1-thiocarbamoyl-3-(4-methoxyphenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole (15) were found as potent as clorgyline (Palaska 2008).…”

Synthesis and pharmacological evaluation of some new fluorine containing hydroxypyrazolines as potential anticancer and antioxidant agents

“…Pyrazolines are used as anticancer [18,19], antioxidant [20], antitumor [21], anti-inflammatory [22], trypanocidal [23], MAO-B inhibitors [24], agonist of cannabinoid receptors [25] and antidepressant agents [26]. Therefore, the pyrazoline motif makes up the core structure of numerous biologically active compounds.…”