Interactions between gastro-oesophageal reflux disease and eosinophilic oesophagitis

Molina–Infante, Javier; Rhijn, Bram D. van

doi:10.1016/j.bpg.2015.06.009

Cited by 24 publications

(14 citation statements)

References 56 publications

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“…Finally, we do agree with Molina-Infante et al that GERD may play a role in PPI-REE by being one of the triggering events in an antigen-driven oesophageal eosinophilia, 10 as clearly reported in our investigation. Therefore, a close relationship between PPI-REE and GERD has been rightly hypothesised and our findings seem to reinforce this possible link.…”

supporting

confidence: 94%

Letter: proton pump inhibitor‐responsive oesophageal eosinophilia – more than just gastro‐oesophageal reflux disease. Authors' reply

Savarino

Girardin

Coletta

et al. 2016

Aliment Pharmacol Ther

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supporting

confidence: 94%

Letter: proton pump inhibitor‐responsive oesophageal eosinophilia – more than just gastro‐oesophageal reflux disease. Authors' reply

Savarino

Girardin

Coletta

et al. 2016

Aliment Pharmacol Ther

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“…It is recommended that esophageal biopsies should be obtained in all patients suspected of having EoE, including all patients who undergo upper endoscopic evaluation for dysphagia or food impaction, regardless of the endoscopic appearance or findings. Consensus guidelines require symptoms of esophageal dysfunction, 15 or more eosinophils per high-power field on microscopic examination of esophageal biopsy after 8 weeks on a high-dose proton pump inhibitor (PPI), and the absence of alternative causes of eosinophilia 22,23 .…”

Section: Discussionmentioning

confidence: 99%

Esophageal foreign body impaction as a presentation of underlying eosinophilic esophagitis

Opriță¹,

Ilie²,

Șandru³

2019

Arch Balk Med Union

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Impaction alimentaire oesophagienne se présentant comme une oesophagite éosinophile sous-jacente Introduction. L'oesophagite éosinophilique (EoE) est une pathologie rare caractérisée par une inflammation chronique avec infiltration éosinophilique des muqueuses de l'oesophage. Les symptômes cliniques varient selon les groupes d'âge: douleur abdominale et thoracique récurrente, vomissements, dysphagie, impaction alimentaire et reflux gastro-oesophagien réfractaire au traitement par inhibiteurs de la pompe à protons. Au cours des dernières années, différentes études suggèrent que l'EoE est désormais la principale cause d'impaction alimentaire chez la population adulte. Présentation du cas. Une femme âgée de 30 ans, sans antécédents personnels pathologiques, a été admise avec des symptômes d'impaction alimentaire oesophagienne. L'endoscopie supérieure a révélé des anneaux oesophagiens et le bolus touché dans le bas de l'oesophage. Des échantillons de biopsie ont été obtenus à plusieurs endroits différents, y compris dans des zones éloignées du site de l'impaction alimentaire. L'examen histopathologique a révélé un infiltrat ABSTRACT Introduction. Eosinophilic esophagitis (EoE) is a rare pathology characterized by chronic inflammation with mucosal eosinophilic infiltrate of the esophagus. The clinical symptoms vary according to the age group, from recurrent abdominal and thoracic pain, vomiting, dysphagia, food impaction and gastroesophageal reflux symptoms refractory to treatment with proton pump inhibitors. In the recent years, different studies suggest that EoE is now the leading cause of food impaction in the adult population. Case presentation. A 30-year-old female, without a pathological personal history, was admitted with symptoms of esophageal food impaction. Upper endoscopy revealed esophageal rings and the bolus impacted in the lower esophagus. Biopsy samples were obtained from several different locations, including areas away from the site of food impaction. Histopathologic examination revealed esophageal mucosal eosinophilic infiltrate >15 eosinophils per high-power field. Proton pump inhibitor (PPI) therapy, twice-daily dosing for 8 weeks was administered, as the first line treatment. Conclusions. Consensus guidelines for the diagnosis of EoE require symptoms of esophageal dysfunction,

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“…Finally, there is evidence of abnormal enteric innervation in CDH and it is likely that esophago-gastric peristalsis is abnormal [10]. The clinical presentation of CDH-associated GERD may vary, including recurrent vomiting and regurgitation, recurrent episodes of bradycardia and respiratory arrest, failure to thrive and recurrent pneumonia [11]. In adult CDH survivors, incidence of esophagitis complicating GERD is 54 %, which is significantly higher than the expected 2 % of endoscopic assessed esophagitis in the general adult population [12].…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic esophagitis after congenital diaphragmatic hernia

Licari

2016

Ital J Pediatr

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BackgroundEosinophilic esophagitis (EoE) is an increasingly diagnosed disease, especially in the western world. Although its pathogenesis remains poorly understood, there is strong evidence that the eosinophilic inflammation in EoE is primarily triggered by immune dysregulation secondary to allergic sensitization to dietary or aero-allergens. Recent studies have reported a higher prevalence of EoE in children with congenital gastrointestinal malformations, i.e. esophageal atresia and/or tracheoesophageal fistula.Case presentationWe present the case history of a 2-year-old boy who developed EoE in the aftermath of congenital diaphragmatic hernia (CDH) repair.ConclusionsTo the best of our knowledge, the following case report describes for the first time the possible association between CDH and EoE. Given the increasing reported prevalence of EoE in children with congenital gastrointestinal malformations, EoE should be rule out also in CDH survivors.

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Interactions between gastro-oesophageal reflux disease and eosinophilic oesophagitis

Cited by 24 publications

References 56 publications

Letter: proton pump inhibitor‐responsive oesophageal eosinophilia – more than just gastro‐oesophageal reflux disease. Authors' reply

Letter: proton pump inhibitor‐responsive oesophageal eosinophilia – more than just gastro‐oesophageal reflux disease. Authors' reply

Esophageal foreign body impaction as a presentation of underlying eosinophilic esophagitis

Eosinophilic esophagitis after congenital diaphragmatic hernia

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