Interactions between Ibuprofen and Silicified-MCC: Characterization, Drug Release and Modeling Approaches

Sahoo, Rudra Narayan; Nanda, Ashirbad; Pramanik, Arunima; Nandi, Souvik; Swain, Rakesh; Pradhan, Sukanta Kumar; Mallick, Subrata

doi:10.17344/acsi.2019.5139

Cited by 8 publications

(5 citation statements)

References 32 publications

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“…The calculated n value appeared less than 0.5 of all the formulations. The n value of Peppas model suggested that the release mechanism was predominantly diffusion controlled [54][55][56] . Films containing kaolin showed higher t 50 value than films without kaolin.…”

Section: Resultsmentioning

confidence: 99%

Characterization and Molecular Docking of Kaolin Based Cellulosic Film for Extending Ophthalmic Drug Delivery

Pramanik¹,

Sahoo²,

Nanda³

et al. 2021

ijps

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Pramanik et al.: Molecular Docking of Kaolin Based Cellulosic FilmOphthalmic delivery of dexamethasone can control inflammation and also some forms of uveitis. But it is effective therapeutically over a short period of time and frequent instillation is required. hydroxypropyl methylcellulose matrix films containing dexamethasone were prepared by casting method in presence and absence of particulate kaolin for extending ophthalmic drug delivery. Fourier-transform infrared spectroscopy confirmed the complexation of dexamethasone and kaolin in the film via formation of hydrogen bond and the observed shouldering at 1032 cm -1 increased with corresponding higher amount of kaolin binding. Differential scanning calorimetry thermogram resulted in almost complete amorphization of dexamethasone in the film. X-ray diffractogram demonstrated almost disappearance of kaolinite diffraction and the reduced order of dexamethasone crystal lattice in all the film formulations. Submicrons, tubular and nano-fibrous morphology of the kaolin and drug particles were seen in the scanning electron microscope images of the film. Relatively extended diffusion controlled drug release and ophthalmic permeation behavior were observed with the increase of kaolin loading in the film. Stable complex facilitated the sustained ophthalmic delivery of dexamethasone and prolonged anti-inflammatory activity. Molecular docking study also revealed the complex formation of dexamethasone with kaolin and hydroxypropyl methyl cellulose to understand the fitting and stable configuration of drug-carrier interaction. Kaolin-based hydroxypropyl methyl cellulose hydrogel film containing dexamethasone as a model drug can enhance the corneal residence time for anti-inflammation for an extended period of time.

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Section: Resultsmentioning

confidence: 99%

Characterization and Molecular Docking of Kaolin Based Cellulosic Film for Extending Ophthalmic Drug Delivery

Pramanik¹,

Sahoo²,

Nanda³

et al. 2021

ijps

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“…For visualizing the surface morphology of the experimental crystal products scanning electron microscopy (Carl ZEISS Sigma 300, India) was used. 17 During the study, the crystalline morphology of the samples was visualized by introducing high beam of electrons and through 0.5-1.5 kV accelerated voltage.…”

Section: Scanning Electron Microscopy (Sem)mentioning

confidence: 99%

“…Similar reports for the use of water as release medium for poorly soluble drugs have already been reported earlier including ibuprofen. 17,[23][24][25][26][27][28][29][30][31][32][33] Hu et al reported in vitro drug release of IBU from the experimental micro emulsion in distilled water. 26 It was found that in vitro release profiles of IBU did not show much change in different drug release medium, i.e.…”

Section: Dissolution Of Drugmentioning

confidence: 99%

Improved dissolution of ibuprofen after crystallization from polymeric solution: Correlation with crystal parameter

Sahoo

Satapathy

Mallick

2021

JSCS

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The objective of the present work was to investigate the effect of various hydrophilic polymers like hydroxypropylmethyl cellulose, methyl cellulose, carboxymethyl cellulose and poly vinyl alcohol on the in vitro dissolution property of ibuprofen (IBU) crystallized from aqueous polymeric solutions. By using solvent-change technique, IBU crystal products were produced in presence of the selected polymers. Results showed that in presence of polymers; crystallization yield of IBU was higher than that of pure drug crystal (absence of polymer). SEM photographs revealed visible changes in the crystal morphology in the presence of polymers. The FTIR spectra of the crystallized IBU (polymer-treated) showed a shifting of the acid-dimer peak from 1718 cm-1 to 1721 cm-1 but absence of specific peaks for polymers. XRD study further confirmed absence of polymers in the crystallized IBU as no specific peaks were observed for the polymers. A higher percentage of cumulative drug release was reported for the polymeric-treated IBU crystals than that of plain IBU. Further in vivo studies are warranted to establish the in vitro-in vivo correlation for the future technology transfer of the formulation.

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“…The small changes in the peak shifting and intensity are the indication of amorphization of the drug in the film formulations. [15][16][17][18]…”

Section: Ftir Studymentioning

confidence: 99%

Effect of Plasticizer on Delivery of Valsartan from Tamarind Gel Based Transdermal Film Formulation

Panda¹,

Chatterjee²,

Sahoo³

et al. 2020

IJPER

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Interactions between Ibuprofen and Silicified-MCC: Characterization, Drug Release and Modeling Approaches

Cited by 8 publications

References 32 publications

Characterization and Molecular Docking of Kaolin Based Cellulosic Film for Extending Ophthalmic Drug Delivery

Characterization and Molecular Docking of Kaolin Based Cellulosic Film for Extending Ophthalmic Drug Delivery

Improved dissolution of ibuprofen after crystallization from polymeric solution: Correlation with crystal parameter

Effect of Plasticizer on Delivery of Valsartan from Tamarind Gel Based Transdermal Film Formulation

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