Interactions between mecamylamine and alcohol in Long–Evans rats: Flash-evoked potentials, body temperature, behavior, and blood alcohol concentration

Hetzler, Bruce E.; Bauer, Alison M.

doi:10.1016/j.pnpbp.2012.11.016

Cited by 6 publications

(7 citation statements)

References 53 publications

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“…Hetzler and Martin (2006) showed that in freely moving rats ethanol had the strongest effect on FEP components P 22 , N 29 and N 53 , while in the present experiment the strongest effect was recorded on component N 143 . Based on the assumption that N 63 and P 89 results from connections between the superior colliculus, brain stem and diffuse thalamic projections (Creel et al 1974), and component N 143 reflects secondary (or rebound) activation of cortical pyramidal cells (Hetzler and Bauer 2013), our study shows that ethanol produced stronger effect on visual cortex than on subcortical structures. These findings are in accordance with the earlier reports based on FEP recordings Coltrera 1975, Begleiter et al 1972).…”

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confidence: 73%

“…Our findings agree with the results of the earlier research. No effect of ethanol on the amplitude of N 63 was found in most studies (Hetzler and Bauer 2013, Hetzler and Martin 2006, Hetzler and Ondracek 2007, Hetzler et al 1981, whereas the amplitude of the late component was reduced by ethanol, suggesting that the depressant doses of ethanol reduced the response to 500 ms visual stimulus offset in the cortical regions.…”

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confidence: 83%

“…It has been shown that cortical structures were more susceptible to the depressant effect of ethanol than subcortical structures (Begleiter and Coltrera 1975). Further studies have shown that amplitude and latency of individual components responded differently to acute ethanol application (Hetzler and Bauer 2013, Hetzler and Bednarek 2001, Hetzler and Martin 2006, Hetzler and Ondracek 2007, Hetzler et al 1981, Hetzler et al 2008.…”

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confidence: 99%

“…One of the best methods to investigate temporal resolution of the sensory processing is to record visual evoked potentials (VEP) -responses to light flash (up to 5 ms). Individual VEP components reflect different stages of visual stimulus processing (Hetzler and Bauer 2013). In the rat, VEP component N 63 reflects intracortical or subcortical (but not direct dLGN) input to the VC, P 89 results from connections between the superior colliculus, brainstem and diffuse thalamic projections (Creel et al 1974) and N 143 represents secondary activation of cortical pyramidal cells (Meeren et al 1998).…”

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confidence: 99%

“…It is known, that the amplitude of FEP is affected by both small (activating effect) and large (depressant effect) doses of ethanol. However, the results of studies in rats are ambiguous and suggest that the effect of ethanol is different on various FEP components: N 29 , N 39 , P 88 , N 139 , P 234 were reduced by ethanol, P 22 , N 53 , N 65 were not affected, and the amplitude of the component P 46 was increased (Hetzler and Bauer 2013, Hetzler and Bednarek 2001, Hetzler and Martin 2006. In contrast to the effect of ethanol on latency, the amplitude of late components was shown to be more affected by ethanol than the early components (Hetzler et al 1981).…”

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confidence: 99%

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Effect of ethanol on the visual‑evoked potential in rat:dynamics of ON and OFF responses

Dulinskas¹,

Buisas²,

Vengeliene³

et al. 2017

Acta Neurobiologiae Experimentalis

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The effect of acute ethanol administration on the flash visual-evoked potential (VEP) was investigated in numerous studies. However, it is still unclear which brain structures are responsible for the differences observed in stimulus onset (ON) and offset (OFF) responses and how these responses are modulated by ethanol. The aim of our study was to investigate the pattern of ON and OFF responses in the visual system, measured as amplitude and latency of each VEP component following acute administration of ethanol. VEPs were recorded at the onset and offset of a 500 ms visual stimulus in anesthetized male Wistar rats. The effect of alcohol on VEP latency and amplitude was measured for one hour after injection of 2 g/kg ethanol dose. Three VEP components-N63, P89 and N143-were analyzed. Our results showed that, except for component N143, ethanol increased the latency of both ON and OFF responses in a similar manner. The latency of N143 during OFF response was not affected by ethanol but its amplitude was reduced. Our study demonstrated that the activation of the visual system during the ON response to a 500 ms visual stimulus is qualitatively different from that during the OFF response. Ethanol interfered with processing of the stimulus duration at the level of the visual cortex and reduced the activation of cortical regions.

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confidence: 73%

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confidence: 83%