Interactions between nitric oxide and dopamine in inhibitory learning and memory in newborn rats

NADPH-diaphorase in the Developing Brain of the Degu (Octodon Degus). Relation to Aminergic Transmitters.

“…The appearance of a relatively mature nitridergic system in the mPFC of newborn degus and the local interaction of TH-and 5-HT fibers with NADPH-d containing neurons support the idea that the diffusible transmitter nitric oxide could play a role in juvenile learning processes as was described for rats [19]. Dopaminergic and nitridergic mechanisms may interact by improving learning and memory processes [20], however, more detailed investigations are required to evaluate such mechanisms in juvenile filial learning of degus.…”

“…Several experiments in rodents and in primates showed that the PFC is involved in working memory [9, 13,14], social behavior [6,8,29] response learning [7] and in juvenile learning processes [24]. The putative retrograde transmitter NO is considered to be involved in learning and memory processes [4,33] and seems also to influence juvenile learning [19,20]. The appearance of a relatively mature nitridergic system in the mPFC of newborn degus and the local interaction of TH-and 5-HT fibers with NADPH-d containing neurons support the idea that the diffusible transmitter nitric oxide could play a role in juvenile learning processes as was described for rats [19].…”