Interactions Between Peptide Assemblies and Proteins for Medicine

Mañas‐Torres, Mari C.; Illescas‐Lopez, Sara; Gavira, José A.; Cienfuegos, Luı́s Álvarez de; Marchesan, Silvia

doi:10.1002/ijch.202200018

Cited by 7 publications

(6 citation statements)

References 112 publications

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“…A two-dimensional nanotube network, functionalized with Fmoc-dipeptides and GdL (or Na 2 CO 3 , in the case of control samples) is connected between the contacts. Both chiral (6,5) and achiral SWCNTs were tested in this work. No significant effect of CNT chirality on CISS was observed, and the data shown in this paper correspond to (6,5) CNTs.…”

Section: Resultsmentioning

confidence: 99%

“…Short-peptide supramolecular hydrogels have turned out to be excellent materials with multiple bio- and technological applications. − Some of these applications are due to the way these peptides self-assemble to form the hydrogel. In particular, aromatic short-peptides such as Fmoc (fluorenylmethoxicarbonyl)- or Nap (2-naphthylacetic acid)-dipeptides, are extremely versatile, being able to self-assemble under the influence of multiple and diverse stimuli, such as solvent and pH switch, change in temperature, the presence of different salts, the action of enzymes, etc. − This versatility has been very useful to develop hydrogels for different applications, such as tissue engineering , and drug delivery, , and to control the type and morphology of the polymeric fibers and the macroscopic and physical properties of the resulting gels. − Furthermore, the stimulus process has also been key in obtaining hybrid or composite materials .…”

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confidence: 99%

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Chirality-Induced Spin Selectivity in Heterochiral Short-Peptide–Carbon-Nanotube Hybrid Networks: Role of Supramolecular Chirality

et al. 2022

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Supramolecular short-peptide assemblies have been widely used for the development of biomaterials with potential biomedical applications. These peptides can self-assemble in a multitude of chiral hierarchical structures triggered by the application of different stimuli, such as changes in temperature, pH, solvent, etc. The self-assembly process is sensitive to the chemical composition of the peptides, being affected by specific amino acid sequence, type, and chirality. The resulting supramolecular chirality of these materials has been explored to modulate protein and cell interactions. Recently, significant attention has been focused on the development of chiral materials with potential spintronic applications, as it has been shown that transport of charge carriers through a chiral environment polarizes the carrier spins. This effect, named chiralityinduced spin selectivity or CISS, has been studied in different chiral organic molecules and materials, as well as carbon nanotubes functionalized with chiral molecules. Nevertheless, this effect has been primarily explored in homochiral systems in which the chirality of the medium, and hence the resulting spin polarization, is defined by the chirality of the molecule, with limited options for tunability. Herein, we have developed heterochiral carbon-nanotube−shortpeptide materials made by the combination of two different chiral sources: that is, homochiral peptides (L/D) + glucono-δlactone. We show that the presence of a small amount of glucono-δ-lactone with fixed chirality can alter the supramolecular chirality of the medium, thereby modulating the sign of the spin signal from "up" to "down" and vice versa. In addition, small amounts of glucono-δ-lactone can even induce nonzero spin polarization in an otherwise achiral and spin-inactive peptide− nanotube composite. Such "chiral doping" strategies could allow the development of complementary CISS-based spintronic devices and circuits on a single material platform.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

Chirality-Induced Spin Selectivity in Heterochiral Short-Peptide–Carbon-Nanotube Hybrid Networks: Role of Supramolecular Chirality

et al. 2022

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“…Short-peptide supramolecular hydrogels are extremely versatile materials with remarkable bio- and technological applications. − Representative examples of this family are tri- and dipeptides containing an aromatic fluorenylmethoxicarbonyl (Fmoc) or naphthyl (Nap) protecting group. , From a synthetic point of view, these molecules are very simple, which makes them easily accessible and economically affordable, and many of them are commercially available. All of these factors have contributed to broadening the use of these peptides to develop and explore materials. − Another key characteristic of these peptides is their ability to self-assemble under the application of different stimuli, such as solvent or pH switch, addition of salts, or enzymatic reactions. , This can be exploited to induce gelation under physiological conditions, making them highly compatible with biomedical applications .…”

Section: Introductionmentioning

confidence: 99%

Biocompatible Short-Peptides Fibrin Co-assembled Hydrogels

Gila-Vilchez

Mañas‐Torres

García-García

et al. 2023

ACS Appl. Polym. Mater.

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Fibrin hydrogels made by self-assembly of fibrinogen obtained from human plasma have shown excellent biocompatible and biodegradable properties and are widely used in regenerative medicine. The fibrinogen self-assembly process can be triggered under physiological conditions by the action of thrombin, allowing the injection of pregel mixtures that have been used as cell carriers, wound-healing systems, and bio-adhesives. However, access to fibrinogen from human plasma is expensive and fibrin gels have limited mechanical properties, which make them unsuitable for certain applications. One solution to these problems is to obtain composite gels made of fibrin and other polymeric compounds that improve their mechanical properties and usage. Herein, we prepared composite hydrogels made by the self-assembly of fibrinogen together with Fmoc-FF (Fmoc-diphenylalanine) and Fmoc-RGD (Fmoc-arginine-glycine-aspartic acid). We have shown that the mixture of these three peptides co-assembles and gives rise to a unique type of supramolecular fiber, whose morphology and mechanical properties can be modulated. We have carried out a complete characterization of these materials from chemical, physical, and biological points of view. Composite gels have improved mechanical properties compared to pure fibrin gels, as well as showing excellent biocompatibility ex vivo. In vivo experiments have shown that these gels do not cause any type of inflammatory response or tissue damage and are completely resorbed in short time, which would enable their use as vehicles for cell, drug, or growth factor release.

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“…As such, we wondered if short-peptide supramolecular hydrogels could be an ideal medium for the in situ growth of MOFs. These hydrogels have shown many advantages such as economic affordability, precise composition, as well as tunable mechanical, chemical, and biological properties, being used in a multitude of fields. − These peptides self-assemble into long fibers by the addition of metallic salts − which could promote the in situ MOF growth as well as obtain homogeneous composite materials in which MOF particles could be broadly dispersed.…”

Section: Introductionmentioning

confidence: 99%

Short-Peptide Supramolecular Hydrogels for In Situ Growth of Metal–Organic Framework-Peptide Biocomposites

Illescas‐Lopez

Martin-Romera

Mañas‐Torres

et al. 2023

ACS Appl. Mater. Interfaces

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The development of bio-MOFs or MOF biocomposites through the combination of MOFs with biopolymers offers the possibility of expanding the potential applications of MOFs, making use of more environmentally benign processes and reagents and giving rise to a new generation of greener and more bio-oriented composite materials. Now, with the increasing use of MOFs for biotechnological applications, the development of new protocols and materials to obtain novel bio-MOFs compatible with biomedical or biotechnological uses is needed. Herein, and as a proof of concept, we have explored the possibility of using short-peptide supramolecular hydrogels as media to promote the growth of MOF particles, giving rise to a new family of bio-MOFs. Short-peptide supramolecular hydrogels are very versatile materials that have shown excellent in vitro and in vivo biomedical applications such as tissue engineering and drug delivery vehicles, among others. These peptides self-assemble by noncovalent interactions, and, as such, these hydrogels are easily reversible, being more biocompatible and biodegradable. These peptides can self-assemble by a multitude of stimuli, such as changes in pH, temperature, solvent, adding salts, enzymatic activity, and so forth. In this work, we have taken advantage of this ability to promote peptide self-assembly with some of the components required to form MOF particles, giving rise to more homogeneous and well-integrated composite materials. Hydrogel formation has been triggered using Zn 2+ salts, required to form ZIF-8, and formic acid, required to form MOF-808. Two different protocols for the in situ MOF growth have been developed. Finally, the MOF-808 composite hydrogel has been tested for the decontamination of water polluted with phosphate ions as well as for the catalytic degradation of toxic organophosphate methyl paraoxon in an unbuffered solution.

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Interactions Between Peptide Assemblies and Proteins for Medicine

Cited by 7 publications

References 112 publications

Chirality-Induced Spin Selectivity in Heterochiral Short-Peptide–Carbon-Nanotube Hybrid Networks: Role of Supramolecular Chirality

Chirality-Induced Spin Selectivity in Heterochiral Short-Peptide–Carbon-Nanotube Hybrid Networks: Role of Supramolecular Chirality

Biocompatible Short-Peptides Fibrin Co-assembled Hydrogels

Short-Peptide Supramolecular Hydrogels for In Situ Growth of Metal–Organic Framework-Peptide Biocomposites

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