Interactions of aluminium hydrolytic species with biomolecules

Deschaume, Olivier; Fournier, Agathe C.; Shafran, Kirill L.; Perry, Carole C.

doi:10.1039/b805406c

Cited by 20 publications

(28 citation statements)

References 32 publications

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“…Our research aims to understand how charge, morphology and the structure of the aluminium species influence how they interact with proteins [50,51]. Our research aims to understand how charge, morphology and the structure of the aluminium species influence how they interact with proteins [50,51].…”

Section: Towards Improved Aluminium-containing Materialsmentioning

confidence: 99%

From biominerals to biomaterials: the role of biomolecule–mineral interactions

Perry

Patwardhan

Deschaume

2009

Biochemical Society Transactions

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Interactions between inorganic materials and biomolecules at the molecular level, although complex, are commonplace. Examples include biominerals, which are, in most cases, facilitated by and in contact with biomolecules; implantable biomaterials; and food and drug handling. The effectiveness of these functional materials is dependent on the interfacial properties, i.e. the extent of molecular level 'association' with biomolecules. The present article gives information on biomolecule-inorganic material interactions and illustrates our current understanding using selected examples. The examples include (i) mechanism of biointegration: the role of surface chemistry and protein adsorption, (ii) towards improved aluminium-containing materials, and (iii) understanding the bioinorganic interface: experiment and modelling. A wide range of experimental techniques (microscopic, spectroscopic, particle sizing, thermal methods and solution methods) are used by the research group to study interactions between (bio)molecules and molecular and colloidal species that are coupled with computational simulation studies to gain as much information as possible on the molecular-scale interactions. Our goal is to uncover the mechanisms underpinning any interactions and to identify 'rules' or 'guiding principles' that could be used to explain and hence predict behaviour for a wide range of (bio)molecule-mineral systems.

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Section: Towards Improved Aluminium-containing Materialsmentioning

confidence: 99%

From biominerals to biomaterials: the role of biomolecule–mineral interactions

Perry

Patwardhan

Deschaume

2009

Biochemical Society Transactions

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“…40,97 Since both G-12 and GT-16 have no acidic amino acid residues, the bound COO À most probably arose from the C-terminus of these peptides.…”

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confidence: 99%

Direct evidence of ZnO morphology modification via the selective adsorption of ZnO-binding peptides

et al. 2011

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Biomolecule-mediated ZnO synthesis has great potential for the tailoring of ZnO morphology for specific application in biosensors, window materials for display and solar cells, dye-sensitized solar cells (DSSCs), biomedical materials, and photocatalysts due to its specificity and multi-functionality. In this contribution, the effect of a ZnO-binding peptide (ZnO-BP, G-12: GLHVMHKVAPPR) and its GGGC-tagged derivative (GT-16: GLHVMHKVAPPRGGGC) on the growth of ZnO crystals expressing morphologies dependent on the relative growth rates of (0001) and (10 10) planes of ZnO have been studied. The amount of peptide adsorbed was determined by a depletion method using oriented ZnO films grown by Atomic Layer Deposition (ALD), while the adsorption behavior of G-12 and GT-16 was investigated using XPS and a computational approach. Direct evidence was obtained to show that (i) both the ZnO-BP identified by phage display and its GGGC derivative (GT-16) are able to bind to ZnO and modify crystal growth in a molecule and concentration dependent fashion, (ii) plane selectivity for interaction with the (0001) versus the (10 10) crystal planes is greater for GT-16 than G-12; and (iii) specific peptide residues interact with the crystal surface albeit in the presence of charge compensating anions. To our knowledge, this is the first study to provide unambiguous and direct quantitative experimental evidence of the modification of ZnO morphology via (selective and nonselective) adsorption-growth inhibition mechanisms mediated by a ZnO-BP identified from phage display libraries.

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“…Yu et al [231] used 2D NIR to study the pH-induced secondary structure change and binding interaction between bovine serum albumin and famotidine, a histamine H 2 -receptor antagonist. Deschaume et al [236] used 2D IR to study the interactions between polycationic aluminum species and lysozyme or bovine serum albumin and bioinorganic assembly formation. Wang et al [239] used 2D fluorescence to study the binding of pyridazin-3(2H)-one derivative to human serum albumin.…”

Section: Proteins and Peptidesmentioning

confidence: 99%

“…2D IR was used by Deschaume et al [236] to study the interactions between polycationic aluminum species and lysozyme or bovine serum albumin. Concentration of aluminum species was used as the perturbation.…”

Section: Compositionmentioning

confidence: 99%