Interactions of Cephalosporins and Penicillins with Nonpolar Macroporous Styrenedivinylbenzene Copolymers

Salto, Francisco; Prieto, J. E.

doi:10.1002/jps.2600700906

Cited by 18 publications

(3 citation statements)

References 8 publications

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“…The extent of molecular ion suppression for these organic compounds is considerably greater than that found earlier in SI-SIMS spectra typical of metals (8) or metal oxides (7). For example, in the SIMS analysis of PTFE the Si-induced suppression of the major molecular fragment CF+ (m/e 31) has been found to be suppressed by greater than a factor of 1 X 105 compared to a SIMS spectrum taken with normal mounting.…”

mentioning

confidence: 65%

Liquid chromatography of cephalosporin C on substituted polystyrene resins

Sacco¹,

Dellacherie²

1984

Anal. Chem.

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mentioning

confidence: 65%

Liquid chromatography of cephalosporin C on substituted polystyrene resins

Sacco¹,

Dellacherie²

1984

Anal. Chem.

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“…Amberlite XAD-2 was sieved to obtain an adequate fraction of particle sizes with 0.210 mm, 0.297 mm and 0.500 mesh screens. For removal of small particles, the resin was washed with methanol at a Soxhlet extractor [14,15], followed by washing with formic acid buffer pH 3.6, prepared as for removal of methanol [16].…”

Section: Apparatus Process Start-up and Analytical Methodsmentioning

confidence: 99%

Mathematical modeling and experimental breakthrough curves of cephalosporin C adsorption in a fixed-bed column

Burkert

Barbosa

Mazutti

et al. 2011

Process Biochemistry

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This work presents the mathematical modeling of the cephalosporin C (CPC) adsorption process in a fixedbed column. The application of Particle Swarm Optimization (PSO) algorithm for parameter estimation was first considered, which shows to be a useful tool for parameter estimation in adsorption processes. Modeling and simulation of CPC purification showed a good performance during both estimation and validation step. After this, a central composite rotational design (CCRD) was conceived taking into account both the superficial velocity of liquid and column length as process variables with the responses obtained from the application of the model, which works as a process simulator affording a process answer from a given input. It has been shown that the response surface methodology was an efficient optimization tool, since few simulations were required to find the optimum region for independent variables.

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“…Polymeric adsorbents have been widely used in laboratory and industry scale in many areas, such as removal of toxicants from waste water or waste gas, separation or purification of biochemicals, pharmaceuticals, and natural products, because of their high adsorption capacity, ease of regeneration, and recycling use 1–5. However, the low adsorption selectivity limits application ranges of the polymeric sorbents.…”

Section: Introductionmentioning

confidence: 99%

Effects of multiple weak interactions on the binding of phenolic compounds by polymeric adsorbents

Cheng

Tang

Yan

2006

J of Applied Polymer Sci

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To investigate the effects of multiple weak interactions on the binding of phenolic compounds by polymeric adsorbents, macroporous polystyrene (PS) resin and PS-based adsorbents with different hydrogen-bond acceptor atoms (PSÀ ÀCH 2 (À ÀOCH 2 CH 2 ) n À ÀOCH 3 , n ¼ 0, 1, 2, and 3, denoted as PS-EG 0 , PS-EG 1 , PS-EG 2 , and PS-EG 3 ) were prepared. The phenol adsorption strength order on these adsorbents was PS/PS-EG 0 < PS-EG 1 < PS-EG 2 < PS-EG 3 , indicating that the adsorption on PS and PS-EG 0 was driven by hydrophobic and p-p interactions, and the adsorption on PS-EG 1 , PS-EG 2 , and PS-EG 3 was driven by a hydrogen bond in addition to hydrophobic and p-p interactions. PS-EG 2 may adsorb a second phenol molecule on each binding site and PS-EG 3 may adsorb second and third ones. The adsorption strength of resorcinol increased in the order of PS, PS-EG 1 , and PS-EG 2 , indicating that the adsorption was driven by 0, 1, and 2 hydrogen bonds in addition to hydrophobic and p-p interactions. Similarly, the adsorption of phloroglucinol on PS, PS-EG 1 , PS-EG 2 , and PS-EG 3 was driven by 0, 1, 2, and 3 hydrogen bonds in addition to hydrophobic and p-p interactions because the adsorption strength increased in this order.

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Interactions of Cephalosporins and Penicillins with Nonpolar Macroporous Styrenedivinylbenzene Copolymers

Cited by 18 publications

References 8 publications

Liquid chromatography of cephalosporin C on substituted polystyrene resins

Liquid chromatography of cephalosporin C on substituted polystyrene resins

Mathematical modeling and experimental breakthrough curves of cephalosporin C adsorption in a fixed-bed column

Effects of multiple weak interactions on the binding of phenolic compounds by polymeric adsorbents

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