Interactions of methylated adenine derivatives with the mercury electrode

Paleček, Emil; Osteryoung, Janet; Osteryoung, R. A.

doi:10.1021/ac00245a030

Cited by 72 publications

(16 citation statements)

References 36 publications

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“…Association of unmodified bases, nucleosides and nucleotides at the mercury surface at higher bulk concentrations was earlier described [34,35]. High electron yield catalytic peak of DNA-Os(VIII)bipy adducts was earlier shown to be of great analytical value, including its use in DNA sensors [6,25,36,37].…”

Section: Cyclic Voltammetry Of Os Bipy-modified Thymine Nucleosidesmentioning

confidence: 94%

Covalent Labeling of Nucleosides with VIII‐ and VI‐Valent Osmium Complexes

et al. 2007

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Osmium tetroxide complexes with nitrogen ligands [Os(VIII)L] have been widely applied as probes of the DNA structure and as electroactive labels of DNA. Here we describe the electrochemical behavior of Os(VIII)2,2-bipyridine (Os, bipy)-base-labeled nucleosides. We show that electroactive label can be introduced also in the nucleoside ribose residues using six-valent osmium complex. Cyclic voltammograms of sugar-Os(VI)-modified ribosides are similar but not identical to those of the base-modified ribosides. Our results showing the electroactivity of sugar modified ribosides pave the way to facile end-labeling of RNA.

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Section: Cyclic Voltammetry Of Os Bipy-modified Thymine Nucleosidesmentioning

confidence: 94%

Covalent Labeling of Nucleosides with VIII‐ and VI‐Valent Osmium Complexes

et al. 2007

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“…28 Therefore, it can be said that Hg(I)NH-R formed according to the sugges- tion of other authors in the literature. 15,29,30 Finally, this peak can be interpreted as a reduction of mercury salt of CP on the mercury surface under these conditions. Similarly, cefaclor exhibited a peak at -0.67 V in B-R buffer pH 10.…”

Section: The Voltammetric Behavior Of Cpmentioning

confidence: 94%

Anaerobic Hydrolytic Degradation of Cefpodoxime Proxetil in the Presence of UV Irradiation and in Darkness: Kinetics and pH Effect

Bíçer¹,

Özdemir²,

Özdemír³

2013

Croat. Chem. Acta

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Abstract. In this study, the anaerobic hydrolytic degradation of cefpodoxime proxetil (CP) in the presence of UV-light irradiation and in darkness has been studied at Britton-Robinson (B-R) buffer solutions (pH 2.5-11) by cyclic and square-wave voltammetry techniques. By means of these electrochemical techniques, the hydrolytic degradation of CP was successfully followed. The pH effect on this degradation was also investigated. In darkness, the decrease in the peak current of CP was not practically observed at the acidic and physiological pHs (2.5, 5.0 and 7.4). But, in the basic medium (pH 9.0 and 11.0), a decrease in the peak current was detected. On the other hand, UV irradiation caused a decrease in the peak current of CP and a positive shift in its cathodic peak potential. Under the UV irradiation, the maximum stability of CP was observed in B-R buffer of pH 5. It has been determined that UV irradiation has a great effect on hydrolytic degradation of CP at basic medium. On the other hand, at pHs  7.4, a new peak has been also obtained at more positive potential than that of the first reduction peak of CP. The current of this peak increases by increasing UV irradiation time. This peak could be assigned to the reduction of a new electroactive product which was formed from the hydrolytic degradation of CP under UV irradiation. The hydrolytic degradation reaction of CP followed pseudo-first order kinetics.(doi: 10.5562/cca2071)

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“…Thus, electrochemical study of adenine or its residues from DNA samples have been undertaken on various electrode materials, e.g., pyrolytic graphite electrode [3 ± 4], glassy carbon electrode [5 ± 10], carbon paste electrode [11], mercury electrode [12]. Certain chemically modified electrodes have also been used for the determination of adenine content in DNA or RNA [13].…”

mentioning

confidence: 99%

Voltammetric and Differential Pulse Stripping Study of Adenine on a Sol‐gel Derived Carbon Composite Electrode

et al. 2004

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This communication reports on the electrochemical investigation of adenine on a sol-gel carbon composite electrode (CCE). Cyclic voltammetric (CV) technique is used to characterize the redox behavior of adenine at CCE. The peak current and peak potentials are dependent on the pH of the buffer solution. From the scan rate and peak current study, there is evidence of adsorption of adenine on the CCE. The parameters affecting the differential pulse stripping adsorption peak were systematically optimized. Under optimum conditions of E acc À 0.10 and t acc 60 s, a linear calibration plot was obtained, 2 Â 10 À7 ± 1 Â 10 À6 M. This CCE is useful for the simultaneous analysis of adenine and guanine from denatured DNA.

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Interactions of methylated adenine derivatives with the mercury electrode

Cited by 72 publications

References 36 publications

Covalent Labeling of Nucleosides with VIII‐ and VI‐Valent Osmium Complexes

Covalent Labeling of Nucleosides with VIII‐ and VI‐Valent Osmium Complexes

Anaerobic Hydrolytic Degradation of Cefpodoxime Proxetil in the Presence of UV Irradiation and in Darkness: Kinetics and pH Effect

Voltammetric and Differential Pulse Stripping Study of Adenine on a Sol‐gel Derived Carbon Composite Electrode

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