Interactions of somatosensory evoked potentials: simultaneous stimulation of two nerves

Okajima, Yasutomo; Chino, Naoichi; Saitoh, Eiichi; Kimura, Akio

doi:10.1016/0168-5597(91)90039-z

Cited by 33 publications

(13 citation statements)

References 30 publications

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“…This process is known as sensory gating. Similar interaction effects have been found using electrical nerve stimulation (Ishibashi et al 2000, Okajima et al 1991 or using a combination of stimuli with different sensory or sensorimotor modalities (Abbruzzese et al 1980, Cheron et al 1991, Kakigi 1986. Several studies have shown that this deviation from linear addition is related to the physical distance between the two stimulation sites.…”

Section: Introductionmentioning

confidence: 52%

Transient and steady-state responses to mechanical stimulation of different fingers reveal interactions based on lateral inhibition

Severens

Farquhar

Desain

et al. 2010

Clinical Neurophysiology

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Section: Introductionmentioning

confidence: 52%

Transient and steady-state responses to mechanical stimulation of different fingers reveal interactions based on lateral inhibition

Severens

Farquhar

Desain

et al. 2010

Clinical Neurophysiology

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“…three sites for the digits and two sites for the lips) and their proximity, to the observed adaptation patterns. A typical approach to address this issue implies additional recordings for each stimulation site, with stimuli independently delivered to each of the functionally related areas (Okajima et al, 1991; Huttunen et al, 1992; Hsieh et al, 1995), or with stimuli delivered simultaneously at multiple skin sites in each condition (i.e. digits vs. lips) while varying the number and proximity of the stimulated sites.…”

Section: Discussionmentioning

confidence: 99%

“…The simultaneous stimulation strategy was chosen to replicate behaviorally natural conditions that require functional integration of tactile stimuli from skin areas of adjacent digits or from upper and lower lips. Previous studies have indicated that in the presence of simultaneous somatosensory stimulation at multiple sites considerable interaction occurs at different levels along the sensory pathway (Okajima et al, 1991; Huttunen et al, 1992; Gandevia et al, 1983; Hsieh et al, 1995). These interactions were observed in the subcortical sensory relay nuclei (including the cuneate nucleus and the sensory thalamic nucleus), and were predominant within regions of the primary somatosensory cortex.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous stimulation of the digits and lips evokes responses with different adaptation patterns in primary somatosensory cortex

et al. 2010

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Neuromagnetic evoked fields were recorded to compare the adaptation of the primary somatosensory cortex (SI) response to tactile stimuli delivered to the glabrous skin at the fingertips of the first three digits (condition 1) and between midline upper and lower lips (condition 2). The stimulation paradigm allowed to characterize the response adaptation in the presence of functional integration of tactile stimuli from adjacent skin areas in each condition. At each stimulation site, cutaneous stimuli (50 ms duration) were delivered in three runs, using trains of 6 pulses with regular stimulus onset asynchrony (SOA). The pulses were separated by SOAs of 500 ms, 250 ms or 125 ms in each run, respectively, while the inter-train interval was fixed (5 s) across runs. The evoked activity in SI (contralateral to the stimulated hand, and bilaterally for lips stimulation) was characterized from the best-fit dipoles of the response component peaking around 70 ms for the hand stimulation, and 8 ms earlier (on average) for the lips stimulation. The SOA-dependent long-term adaptation effects were assessed from the change in the amplitude of the responses to the first stimulus in each train. The short-term adaptation was characterized by the lifetime of an exponentially saturating model function fitted to the set of suppression ratios of the second relative to the first SI response in each train. Our results indicate: 1) the presence of a rate-dependent long-term adaptation effect induced only by the tactile stimulation of the digits; and 2) shorter recovery lifetimes for the digits compared with the lips stimulation.

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“…In particular, an interaction between lemniscal and spinocerebellar inputs has been suggested to occur at a thalamic level Okajima et al 1991). …”

Section: Interactions Between Muscle and Cutaneous Afferent Volleysmentioning

confidence: 99%

Subcortical Interactions Between Somatosensory Stimuli of Different Modalities and Their Temporal Profile

Costa¹,

Valls‐Solé²,

Valldeoriola³

et al. 2008

Journal of Neurophysiology

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Costa J, Valls-Solé J, Valldeoriola F, Rumià J. Subcortical interactions between somatosensory stimuli of different modalities and their temporal profile. J Neurophysiol 100: 1610 -1621, 2008. First published July 2, 2008 doi:10.1152/jn.90412.2008. Interactions between inputs of different sensory modality occur along the sensory pathway, including the thalamus. However, the temporal profile of such interaction has not been fully studied. In eight patients who had been implanted an intrathalamic electrode for deep brain stimulation as symptomatic treatment of tremor, we investigated the interactions between mechanical taps and electrical nerve stimuli. Somatosensory evoked potentials (SEPs) were recorded from Erb's point, cervical spinal cord, nucleus ventrointermedialis of the thalamus, and parietal cortex. A handheld electronic reflex hammer was used to deliver a mechanical tap to the skin overlying the first dorsal interosseous muscle and to trigger an ipsilateral digital median nerve electrical stimulus time-locked to the mechanical tap with a variable delay of 0 to 50 ms. There were significant time-dependent interactions between the two sensory volleys at the subcortical level. Thalamic SEPs were decreased in amplitude at interstimulus intervals (ISIs) from 10 to 40 ms with maximum effect at 20 ms (Ϫ42.8 Ϯ 10.5%; P Ͻ 0.001). A similar decrease was also seen in the number and frequency of the high-frequency components of thalamic SEPs (Ϫ25 Ϯ 4%). A smaller reduction (Ϫ18.1 Ϯ 5.8%; P Ͻ 0.001) was present in upper cervical response at ISI ϭ 20 ms. There were no changes in peripheral responses. Cortical SEPs were almost completely absent in some subjects at ISIs from 20 to 50 ms. There were no changes in SEP latencies. Our results indicate that significant time-dependent interactions between sensory volleys occur at the subcortical level. These observations provide further insight into the physiological mechanisms underlying afferent gating between sensory volleys of different modality.

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Interactions of somatosensory evoked potentials: simultaneous stimulation of two nerves

Cited by 33 publications

References 30 publications

Transient and steady-state responses to mechanical stimulation of different fingers reveal interactions based on lateral inhibition

Transient and steady-state responses to mechanical stimulation of different fingers reveal interactions based on lateral inhibition

Cutaneous stimulation of the digits and lips evokes responses with different adaptation patterns in primary somatosensory cortex

Subcortical Interactions Between Somatosensory Stimuli of Different Modalities and Their Temporal Profile

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