Interactions of the Platinum(II) Complexes with Nitrogen- and Sulfur-Bonding Bio-Molecules in Chronic Lymphocytic Leukemia

Bogojeski, Jovana; Petrović, Biljana; Bugarčić, Živadin D.

doi:10.5772/28585

Cited by 5 publications

(4 citation statements)

References 88 publications

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“…12,13 Also, heterometallic complexes containing palladium and platinum centers, [14][15][16][17][18] compared to cisplatin, interact different with multiple biological targets and therefore could have potential for anticancer activity. 21 However, cells contain some other bio-molecules which can also react with platinum(II) complexes, such as sulfur-donor bio-molecules, thioethers (L-Met) and thiols (L-Cys). 21 However, cells contain some other bio-molecules which can also react with platinum(II) complexes, such as sulfur-donor bio-molecules, thioethers (L-Met) and thiols (L-Cys).…”

Section: Introductionmentioning

confidence: 99%

New bimetallic palladium(ii) and platinum(ii) complexes: studies of the nucleophilic substitution reactions, interactions with CT-DNA, bovine serum albumin and cytotoxic activity

et al. 2016

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Two new dinuclear bimetallic complexes, [{PdCl(bipy)}{μ-(pyrazine)}{PtCl(bipy)}]Cl(ClO4) (1) (bipy is 2,2'-bipyridine) and [{PdCl(en)}{μ-(pyrazine)}{PtCl(en)}]Cl(ClO4) (2) (en is ethylenediamine), have been synthesized and characterized by elemental microanalysis, IR, (1)H NMR spectroscopy and MALDI-TOF mass spectrometry. The pKa values of the coordinated water molecules of the diaqua species were determined as well. Substitution reactions of complexes (1) and (2) with thiourea (Tu), l-methionine (l-Met), l-cysteine (l-Cys), l-histidine (l-His) and guanosine-5'-monophosphate (5'-GMP) were studied under the pseudo-first order conditions as a function of nucleophile concentration and temperature. The order of reactivity of nucleophiles was: Tu > l-Met > l-Cys > l-His > 5'-GMP. Substitution reactions with Tu, l-Cys and l-His were followed by decomposition of bimetallic complexes to the corresponding substituted mononuclear complexes [Pd(N-N)(Nu)2] and [Pt(N-N)(Nu)2] (N-N = bipy, en), releasing the bridging ligand. However, the structures of starting bimetallic complexes were preserved during the reactions with l-Met and 5'-GMP. The absorption spectroscopic study of interactions of calf-thymus DNA (CT-DNA) with complexes (1), (2) and [{PdCl(bipy)}{μ-(NH2(CH2)6H2N)} {PtCl(bipy)}]Cl(ClO4) (3), has shown that all the complexes exhibit high intrinsic binding constants (Kb = 10(4)-10(5) M(-1)). DNA-ethidium bromide (DNA-EB) fluorescence was quenched after addition of complexes (1), (2) or (3), indicating displacement of intercalating EB by complexes. All complexes have shown good binding affinity to bovine serum albumin protein (BSA). Chemosensitivity of A375 (human melanoma) and HeLa (human cervical cancer) cell lines toward complexes (1), (2) and (3) was analyzed by SRB assay. Complex (1) displayed significant inhibitory effect on the growth of both cell lines.

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Section: Introductionmentioning

confidence: 99%

New bimetallic palladium(ii) and platinum(ii) complexes: studies of the nucleophilic substitution reactions, interactions with CT-DNA, bovine serum albumin and cytotoxic activity

et al. 2016

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“…A chemical structure was proposed in Figure c for ALD Pt-coated collagen with and without the ALD TiO 2 buffer layer. Platinum was previously reported to chemically bind with DNA by forming favorable bonds with nitrogen atoms (at N7 sites) of the adenine and guanine bases of the DNA. , Therefore, the Pt ALD coating might bind with the available surface nitrogen of the collagen membrane. On the other hand, the bonding might be different when a TiO 2 buffer layer was present between the Pt coating and collagen.…”

Section: Results and Discussionmentioning

confidence: 99%

Highly Conductive Collagen by Low-Temperature Atomic Layer Deposition of Platinum

Bishal

Anderson

Hung

et al. 2020

ACS Appl. Mater. Interfaces

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Consequences the presence of TiO2 to the electronic properties of Coll-TiO2-Pt Fig. 4d Schematic of electronic structures in the presence of TiO2 with electron charges fulfill the valence energy (Ev) and partially fill the intermediate energy (Ef). The presence of the latter energy enables the charges to easily migrate to the conduction energy band (Ec) and thus they could continuously reach the Pt surface.

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“…In order to determine enthalpies and entropies, that is, activation parameters, the rate of the reaction was measured as a function of temperature, over temperature range 25–45 °C at intervals of 5 °C. Any buffer solution was completely avoided for the reaction as buffer ions (phosphate ion) are effectively bound Pt(II) complexes . The Weyh and Hamm method was applied to calculate the rate constant after executing three independent pharmacokinetic studies and average values were taken.…”

Section: Methodsmentioning

confidence: 99%

“…Any buffer solution was completely avoided for the reaction as buffer ions (phosphate ion) are effectively bound Pt(II) complexes. 29 The Weyh and Hamm method 30 was applied to calculate the rate constant after executing three independent pharmacokinetic studies and average values were taken.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Development of Anticancer Activity of the Pt(II) Complex with N-Heterocyclic Amine: Its In Vitro Pharmacokinetics with Thiol and Thio-Ethers, DNA and BSA Binding, and Cell Cycle Arrest

Pan

Mitra

Mukherjee

et al. 2021

ACS Appl. Bio Mater.

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A dichloro Pt(II) complex with N-heterocyclic amine cis-Pt(PIEAM)Cl2, C-1 (where PIEAM = 1-(2-aminoethyl)piperidine) was synthesized and hydrolyzed to the corresponding [Pt(PIEAM)(OH2)2]2+ C-2 to explore its bioactivity and cytotoxic property. Biorelevant sulfur-containing small tripeptide glutathione (GSH)- and amino acid dl-methionine (dl-meth)-substituted complexes [Pt(PIEAM)(GSH)] C-3 and [Pt(PIEAM)(dl-meth)]+2 C-4 were synthesized and characterized. In vitro pharmacokinetic reactions of complex C-2 → C-3 and C-4 with GSH and dl-meth, respectively, were studied under pseudo-first-order reaction conditions. The high and negative entropy of activation (ΔS ⧧) and low and positive enthalpy of activation (ΔH ⧧) values were deduced from the Eyring equation to propose an associative mechanism. To find out the biotransformation of complex C-1, C-2, and Pt(II)–S chelates C-3 and C-4 to Pt(II)-DNA adducts, DNA binding affinity of C-1–C-4 was examined by UV–visible spectroscopy, fluorescence quenching, and gel electrophoresis methods. BSA binding activity of these complexes was emphasized for their biological importance and the “drug reservoir” activity. Anticancer activity of these complexes on HEp 2 (laryngeal), MDA-MB-231 (breast), and A549 (lung) cancer cell lines was found to be remarkable as compared to the recognized anticancer drugs such as cisplatin, carboplatin, and oxaliplatin. Cell cycle arrest was also explored on HEp 2 cells of the complexes at a concentration corresponding to IC50 value and displayed significant cell death at the sub-G1 phase.

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Interactions of the Platinum(II) Complexes with Nitrogen- and Sulfur-Bonding Bio-Molecules in Chronic Lymphocytic Leukemia

Cited by 5 publications

References 88 publications

New bimetallic palladium(ii) and platinum(ii) complexes: studies of the nucleophilic substitution reactions, interactions with CT-DNA, bovine serum albumin and cytotoxic activity

New bimetallic palladium(ii) and platinum(ii) complexes: studies of the nucleophilic substitution reactions, interactions with CT-DNA, bovine serum albumin and cytotoxic activity

Highly Conductive Collagen by Low-Temperature Atomic Layer Deposition of Platinum

Development of Anticancer Activity of the Pt(II) Complex with N-Heterocyclic Amine: Its In Vitro Pharmacokinetics with Thiol and Thio-Ethers, DNA and BSA Binding, and Cell Cycle Arrest

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