Interactions of zeatin with gold ions and biomimetic formation of gold complexes and nanoparticles

Fowles, Catherine C.; Smoak, Evan M.; Banerjee, Ipsita A.

doi:10.1016/j.colsurfb.2010.03.010

Cited by 7 publications

(4 citation statements)

References 116 publications

(43 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This interaction may have induced changes in morphology of these compounds, thereby increasing their efficiency. The same mechanism has been proposed for the interaction of gold (III) with zeatin [32]. In beta-lactam and cephalosporins such as penicillin and methicillin, this coordination may have happened between Au 3+ and free electrons on sulphur and nitrogen donor groups.…”

Section: +mentioning

confidence: 83%

The combination effects of trivalent gold ions and gold nanoparticles with different antibiotics against resistant Pseudomonas aeruginosa

et al. 2012

View full text Add to dashboard Cite

Despite much success in drug design and development, Pseudomonas aeruginosa is still considered as one of the most problematic bacteria due to its ability to develop mutational resistance against a variety of antibiotics. In search for new strategies to enhance antibacterial activity of antibiotics, in this work, the combination effect of gold materials including trivalent gold ions (Au 3+ ) and gold nanoparticles (Au NPs) with 14 different antibiotics was investigated against the clinical isolates of P. aeruginosa, Staphylococcus aureus and Escherichia coli. Disk diffusion assay was carried out, and test strains were treated with the sub-inhibitory contents of gold nanomaterial. Results showed that Au NPs did not increase the antibacterial effect of antibiotics at tested concentration (40 μg/disc). However, the susceptibility of resistant P. aeruginosa increased in the presence of Au 3+ and methicillin, erythromycin, vancomycin, penicillin G, clindamycin and nalidixic acid, up to 147 %. As an individual experiment, the same group of antibiotics was tested for their activity against clinical isolates of S. aureus, E. coli and a different resistant strain of P. aeruginosa in the presence of sub-inhibitory contents of Au 3+, where Au 3+ increased the susceptibility of test strains to methicillin, erythromycin, vancomycin, penicillin G, clindamycin and nalidixic acid. Our finding suggested that using the combination of sub-inhibitory concentrations of Au 3+ and methicillin, erythromycin, nalidixic acid or vancomycin may be a promising new strategy for the treatment of highly resistant P. aeruginosa infections.

show abstract

Section: +mentioning

confidence: 83%

The combination effects of trivalent gold ions and gold nanoparticles with different antibiotics against resistant Pseudomonas aeruginosa

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Magnetite-gold hybrid nanoparticle, synthesized using grape seed proanthocyanidin as the reducing agent was used as a contrast agent for MRI and CT bioimaging [108]. Fowles et al proposed that gold nanoparticle prepared from zeatin (a plant phytohormone) nanostructures could be used for facile preparation of shape controlled nanoparticles and may open up new avenues for device fabrications in optoelectronics and sensors [109].…”

Section: Other Applications Of Green Nanoparticlementioning

confidence: 99%

Herbonanoceuticals: A New Step Towards Herbal Therapeutics

Gomes¹,

Ghosh²,

Sengupta³

et al. 2014

Medicinal Aromatic Plants

View full text Add to dashboard Cite

“…Further, gibberellic acid may also be used as immunotracers for several biological applications (28,29). In another study, trans-Zeatin has been shown to have the ability to selectively mineralise Au 3þ ions on the surface of its selfassembled nanoarchitectures (30). Thus, self-assembled architectures of biomolecules obtained from naturally occurring phytohormones may allow for the creation of building blocks for the development of nanomaterials with enhanced abilities for various device fabrications from biosensors to electronics and optical devices (31).…”

Section: Introductionmentioning

confidence: 98%

pH tunable self-assembly of chicoric acid and their biocompatibility studies

Smoak

Fath

Barnaby

et al. 2011

Supramolecular Chemistry

Self Cite

View full text Add to dashboard Cite

We report for the first time, the pH tunable self-assembly of chicoric acid, an HIV-I integrase inhibitor, which displayed a remarkable tendency to self-assemble at room temperature into varying nano-and microstructures. Furthermore, those assemblies were then functionalised with gold (Au) nanoparticles. We then investigated the biocompatibility of the materials by conducting in vitro cell attachment and cytotoxicity studies using normal rat kidney cells. The studies revealed that the biomaterials were non-toxic and biocompatible, and showed considerable adhesion to the cells. These results suggest that the assemblies could potentially be used for a variety of applications, such as carriers for targeted drug delivery as well as optoelectronics and sensors. Furthermore, the formation of highly organised nano-and microstructures of medicinally significant phytohormones such as chicoric acid is of particular interest as it might help in further understanding the supramolecular assembly mechanism of higher organised biological structures for the development of building blocks for various device fabrications.

show abstract

Interactions of zeatin with gold ions and biomimetic formation of gold complexes and nanoparticles

Cited by 7 publications

References 116 publications

The combination effects of trivalent gold ions and gold nanoparticles with different antibiotics against resistant Pseudomonas aeruginosa

The combination effects of trivalent gold ions and gold nanoparticles with different antibiotics against resistant Pseudomonas aeruginosa

Herbonanoceuticals: A New Step Towards Herbal Therapeutics

pH tunable self-assembly of chicoric acid and their biocompatibility studies

Contact Info

Product

Resources

About