Interactions with Drugs and Dietary Supplements Used For Weight Loss

Jordan, Melanie A.

doi:10.5772/51145

Cited by 5 publications

(15 citation statements)

References 400 publications

(367 reference statements)

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“…A recent, placebo-controlled, cross-over, double-blinded study however evidenced that bitter orange and p-synephrine were without stimulant (cardiovascular) and hemodynamic effects although the caffeine consumed by the participants varied markedly [29]. Owing to the inhibition of cytochrome P450 (CYP) 3A4 activity, bitter orange can increase blood levels of drugs, such as cyclosporine, an immunosuppressant medication, and saquinavir, an antiretroviral protease inhibitor [16]. Additive effects with antidepressant monoamine oxidase inhibitors (MAOIs) and anti-diabetic drugs have also described [30].…”

Section: Clinical Studiesmentioning

confidence: 99%

“…Caffeine also reduces the bioavailability of [37] alendronate (~60%) [35]. Estrogen drugs decrease clearance of caffeine up to 50-65%, thereby increasing possible adverse effects and possible drug interactions [16].…”

Section: Safety and Drug Interactionsmentioning

confidence: 99%

“…G. cambogia extract could modulate the pharmacokinetics of CYP2B6 substrate drugs, including antitumor drugs (cyclophosphamide, ifosphamide, and sorafenib), antimalarials (artemisinin), antivirals (efavirenz) analgesics (methadone, meperidine), and anticonvulsants (valproic acid) [93]. Antilipemic agents such as 3-hydroxy-3methylglutaryl-CoA (HMG-CoA) reductase inhibitors should be avoided due to an increased risk of rhabdomyolysis [16].…”

Section: Safety and Drug Interactionsmentioning

confidence: 99%

“…Reported adverse effects are similar to those of other watersoluble, fermentable fibers and include abdominal discomfort, bloating, diarrhea, loose stools, belching and flatulence [95][96][97]. There are relatively few reported interferences with absorption of some drugs, especially regarding patients taking antihypertensives, antilipemics, antidiabetics, liposoluble vitamins and anti-obesity agents [16]. Glucomannan has been used as an adjunctive therapeutic agent in the treatment of thyrotoxicosis by increasing the enterohepatic circulation of thyroid hormones [16].…”

Section: Safety and Drug Interactionsmentioning

confidence: 99%

“…Therefore, several patients might turn to dietary weight-loss supplements to achieve and maintain their weight-loss goals, with the a priori assurance of safety and efficacy associated with the term 'natural remedy'. Unfortunately, there is scant information on the intereference of ingredients of weight-loss dietary with certain medications [15,16]. Nevertheless, the thorny issues that may result from drug interactions with weight-loss dietary supplements have been not sufficiently addressed.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Nutritionist and obesity: brief overview on efficacy, safety, and drug interactions of the main weight-loss dietary supplements

Barrea¹,

Altieri²,

Polese³

et al. 2019

Int J Obes Supp

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Over the past 20 years the use of dietary supplements as adjuvant therapy for weight loss gained growing favor among consumers and dietician-nutritionists, with the subsequent astounding increase in health costs. Despite the reassuring label of natural remedy for losing weight, dietary supplements contain a wide variety of ingredients on which available information is rather scanty and scientifically incomplete. Currently, there is little evidence that weight-loss supplements offer effective aids to reduce weight and meet criteria for recommended use. Robust, randomized, placebo-controlled studies to provide clear-cut scientific evidence of their efficacy and potential side effects in clinical practice are still lacking. Understanding the evidence for the efficacy, safety, and quality of these supplements among nutritionists and physicians is critical to counsel patients appropriately, especially considering the risk of serious adverse effects and interference with concomitant therapies. Detailed information on the efficacy and safety of the most commonly used weight-loss dietary supplements has been recently published by the National Institutes of Health (NIH). However, in this report the thorny issue that may result from drug interactions with weight-loss dietary supplements has been not sufficiently addressed. The aim of this review was to provide a synthetic, evidence-based report on efficacy and safety of the most commonly used ingredients in dietary supplements marketed for weight loss, particularly focusing on their possible drug interactions.

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Section: Clinical Studiesmentioning

confidence: 99%

Section: Safety and Drug Interactionsmentioning

confidence: 99%

Section: Safety and Drug Interactionsmentioning

confidence: 99%

Section: Safety and Drug Interactionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Nutritionist and obesity: brief overview on efficacy, safety, and drug interactions of the main weight-loss dietary supplements

Barrea¹,

Altieri²,

Polese³

et al. 2019

Int J Obes Supp

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Herbal supplements interactions with oral oestrogen‐based contraceptive metabolism and transport

Hlengwa

Muller

Basson

et al. 2020

Phytotherapy Research

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The increased use of herbal supplements as complementary or alternative medicines has become a clinical conundrum due to the potential for herb–drug interactions. This is exacerbated by an increased supply of new herbal supplements in the market claiming various health advantages. These herbal supplements are available as over‐the‐counter self‐medications. Herbal supplements are generally perceived as efficacious without side effects commonly associated with conventional drugs. However, despite regulations, claims related to their therapeutic effects are mostly unsupported by scientific evidence. These products often lack suitable product quality controls, labelled inadequately and with batch to batch variations, potentially compromising the safety of the consumer. Amongst health practitioners, the greatest concern is related to the lack of chemical characterization of the active compounds of the herbal supplements. The interaction between these different active components and their concomitant effects on other conventional drugs is generally not known. This review will focus on herbal supplements with the potential to effect pharmacokinetic and pharmacodynamic properties of oestrogen‐based oral contraceptives. The use of herbal supplements for weight management, depression, and immune boosting benefits were selected as likely herbal supplements to be used concomitantly by women on oral contraceptives.

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Use and perceived effectiveness of complementary medicines for weight loss in adult women

Bussicott

Patel

Pellow

et al. 2022

South African Journal of Clinical Nutrition

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Interactions with Drugs and Dietary Supplements Used For Weight Loss

Cited by 5 publications

References 400 publications

Nutritionist and obesity: brief overview on efficacy, safety, and drug interactions of the main weight-loss dietary supplements

Nutritionist and obesity: brief overview on efficacy, safety, and drug interactions of the main weight-loss dietary supplements

Herbal supplements interactions with oral oestrogen‐based contraceptive metabolism and transport

Use and perceived effectiveness of complementary medicines for weight loss in adult women

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