Interactive design and manufacturing of a Voronoi-based biomimetic bone scaffold for morphological characterization

Fantini, Massimiliano; Curto, Marco

doi:10.1007/s12008-017-0416-x

Cited by 56 publications

(30 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar results were observed in the previous works of Van et al [16] , Warnke et al . [32] , Hollander et al [42] , Fantini et al [43] , Sing et al [44] , but not discussed systemically. Firstly, the SLM-produced scaffolds have very rough surface with pores and ravines, resulting from the adhesion of partly melted particles on the struts, which is universal phenomenon in SLM process.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Trabecular-like Ti-6Al-4V scaffolds for orthopedic: fabrication by selective laser melting and in vitro biocompatibility

Liang

Yang

Xie

et al. 2019

Journal of Materials Science & Technology

189

View full text Add to dashboard Cite

Porous metal scaffolds play an important role in the orthopedic field, due to their wide applications in prostheses implantation. Some previous studies showed that the scaffolds with trabecular bone structure reconstructed via computed tomography had satisfactory biocompatibility. However, the reverse modeling scaffolds were inflexible for customized design. Therefore, a top-down designing biomimetic bone scaffold with favorable mechanical performances and cytocompatibility is urgently demanded for orthopedic implants. An emerging additive manufacturing technique, selective laser melting, was employed to fabricate the trabecular-like porous Ti-6Al-4V scaffolds with varying irregularities (0.05-0.5) and porosities (48.83%-74.28%) designed through a novel Voronoi-Tessellation based method. Micro-computed tomography and scanning electron microscopy were used to characterize the scaffolds' morphology. Quasi-static compression tests were performed to evaluate the scaffolds' mechanical properties. The MG63 cells culture in vitro experiments, including adhesion, proliferation, and differentiation, were conducted to study the cytocompatibility of scaffolds. Compressive tests of scaffolds revealed an apparent elastic modulus range of 1. 93-5.24 GPa and an ultimate strength ranging within 44.9-237.5 MPa, which were influenced by irregularity and porosity, and improved by heat treatment. Furthermore, the in vitro assay suggested that the original surface of the SLM-fabricated scaffolds was favorable for osteoblasts adhesion and migration because of micro scale pores and ravines. The trabecular-like porous scaffolds with full irregularity and higher porosity exhibited enhanced cells proliferation and osteoblast differentiation at earlier time, due to their preferable combination of small and large pores with various shapes. This study suggested that selective laser melting-derived Ti-6Al-4V scaffold with the trabecular-like porous structure designed through Voronoi-Tessellation method, favorable mechanical performance, and good cytocompatibility was a potential biomaterial for orthopedic implants.

show abstract

Section: Accepted Manuscriptmentioning

confidence: 99%

Trabecular-like Ti-6Al-4V scaffolds for orthopedic: fabrication by selective laser melting and in vitro biocompatibility

Liang

Yang

Xie

et al. 2019

Journal of Materials Science & Technology

189

View full text Add to dashboard Cite

show abstract

“…Many pieces of research showed that optimum porous design of bone scaffolds should copy natural bone properties (Zhang et al, 2016;Fantini and Curto, 2017). The Voronoi structure is similar to the microstructure of bone in morphology.…”

Section: Based On Voronoimentioning

confidence: 99%

“…The leading morphology indices included the trabecular thickness, trabecular separation, trabecular number, bone volume to total volume ratio, and the bone surface to bone volume ratio. These indices were precisely matched to trabecular bone (Gómez et al, 2016;Fantini and Curto, 2017). However, the Voronoi structure built in this method had inevitable problems such as poor repeatability, energy-consuming, and long-time cycle (Wang et al, 2018;Du et al, 2020).…”

Section: Based On Voronoimentioning

confidence: 99%

“…Bone is a non-uniform porous structure, the density of which gradually increases from the inner cancellous bone to the outer cortical bone. At present, the porous designs of orthopedics are trying to imitate the structure of bone from the following aspects, such as Young's modulus, compression strength, biocompatibility, and bone ingrowth (Weiner et al, 1999;Gómez et al, 2016;Fantini and Curto, 2017).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Porous Scaffold Design for Additive Manufacturing in Orthopedics: A Review

Chen

Han

Wang

et al. 2020

Front. Bioeng. Biotechnol.

154

View full text Add to dashboard Cite

With the increasing application of orthopedic scaffolds, a dramatically increasing number of requirements for scaffolds are precise. The porous structure has been a fundamental design in the bone tissue engineering or orthopedic clinics because of its low Young's modulus, high compressive strength, and abundant cell accommodation space. The porous structure manufactured by additive manufacturing (AM) technology has controllable pore size, pore shape, and porosity. The single unit can be designed and arrayed with AM, which brings controllable pore characteristics and mechanical properties. This paper presents the current status of porous designs in AM technology. The porous structures are stated from the cellular structure and the whole structure. In the aspect of the cellular structure, non-parametric design and parametric design are discussed here according to whether the algorithm generates the structure or not. The non-parametric design comprises the diamond, the body-centered cubic, and the polyhedral structure, etc. The Voronoi, the Triply Periodic Minimal Surface, and other parametric designs are mainly discussed in parametric design. In the discussion of cellular structures, we emphasize the design, and the resulting biomechanical and biological effects caused by designs. In the aspect of the whole structure, the recent experimental researches are reviewed on uniform design, layered gradient design, and layered gradient design based on topological optimization, etc. These parts are summarized because of the development of technology and the demand for mechanics or bone growth. Finally, the challenges faced by the porous designs and prospects of porous structure in orthopedics are proposed in this paper.

show abstract

“…Fantini et al [ 53 ] used the CAD 3D software Rhinoceros with its plug-in Grasshopper to design scaffolds for bone tissue engineering starting from the patient bone geometry and obtaining a porous structure; their work also aimed to correlate the input parameters, including the number of seeds, with the target ones that are the percentage porosity of the structure and the pore size. This generative design process was further proven by fabricating a sample of Ti6Al4V and morphologically analyzing it by a SEM and a high-resolution micro-CT [ 56 ].…”

Section: Cellular Materialsmentioning

confidence: 99%

Geometric Modeling of Cellular Materials for Additive Manufacturing in Biomedical Field: A Review

Savio

Rosso

Meneghello

et al. 2018

Applied Bionics and Biomechanics

View full text Add to dashboard Cite

Advances in additive manufacturing technologies facilitate the fabrication of cellular materials that have tailored functional characteristics. The application of solid freeform fabrication techniques is especially exploited in designing scaffolds for tissue engineering. In this review, firstly, a classification of cellular materials from a geometric point of view is proposed; then, the main approaches on geometric modeling of cellular materials are discussed. Finally, an investigation on porous scaffolds fabricated by additive manufacturing technologies is pointed out. Perspectives in geometric modeling of scaffolds for tissue engineering are also proposed.

show abstract

Interactive design and manufacturing of a Voronoi-based biomimetic bone scaffold for morphological characterization

Cited by 56 publications

References 50 publications

Trabecular-like Ti-6Al-4V scaffolds for orthopedic: fabrication by selective laser melting and in vitro biocompatibility

Trabecular-like Ti-6Al-4V scaffolds for orthopedic: fabrication by selective laser melting and in vitro biocompatibility

Porous Scaffold Design for Additive Manufacturing in Orthopedics: A Review

Geometric Modeling of Cellular Materials for Additive Manufacturing in Biomedical Field: A Review

Contact Info

Product

Resources

About