Interactive effects of 5-HTTLPR genotype and rearing environment on affective attitude towards own infant in Japanese mothers

Sawano, Erika; Doi, Hiroyuki; Nagai, Tomoko; Ikeda, Satoko; Shinohara, K

doi:10.1016/j.bbr.2016.11.001

Cited by 4 publications

(15 citation statements)

References 62 publications

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“…To explain this discrepancy, some researchers hypothesised that genetic factors might interact with environmental components through epigenetic mechanisms (gene X–environment interactions) [ 12 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Parenting and the Serotonin Transporter Gene (5HTTLPR), Is There an Association? A Systematic Review of the Literature

Landoni

Muta

Tella

et al. 2022

IJERPH

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The current systematic review examines whether there is an association between the genetic 5-HTTPLR polymorphism and parenting, and the mechanisms by which this association operates. The literature was searched in various databases such as PubMed, Scopus, and ScienceDirect. In line with our inclusion criteria, nine articles were eligible out of 22. Most of the studies analysed in this review found an association between 5HTTLPR and parenting. Four studies found a direct association between 5-HTTLPR and parenting with conflicting findings: two studies found that mothers carrying the short variant were more sensitive to their infants, while two studies found that parents carrying the S allele were less sensitive. In addition, several studies found strong interaction between genetic and environmental factors, such as childhood stress and disruptive child behaviour, quality of early care experiences, poor parenting environment, and quality of the environment. Only one study found an association between children’s 5HTTLPR and parenting. Parenting can be described as a highly complex construct influenced by multiple factors, including the environment, as well as parent and child characteristics. According to the studies, maternal 5-HTTLPR polymorphism is most likely to be associated with sensitive parenting.

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Section: Introductionmentioning

confidence: 99%

Parenting and the Serotonin Transporter Gene (5HTTLPR), Is There an Association? A Systematic Review of the Literature

Landoni

Muta

Tella

et al. 2022

IJERPH

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“…In very different cultural contexts such as Italy and Japan, bonding experiences interact with genetics (such as the oxytocin receptor gene polymorphisms rs2254298 [7] and rs53576 [8] and the serotonin transporter gene polymorphism (5-HTTLPR,[8][9]) to modulate affective attitude towards either own infant[9] or infants in general[8]. The final two papers of this section describe how environmental factors (e.g., socio-cultural level) as well as individual (e.g., genetic makeup) and interpersonal factors (e.g., caregiver-child relationships) play crucial roles in shaping the development of the personality [10] and how socio-economic status has a strong impact on modulating maternal brain mechanisms that regulate propensity toward own infants [11].…”

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confidence: 99%

The development of attachment: Integrating genes, brain, behavior, and environment

Esposito

Setoh

Shinohara

et al. 2017

Behavioural Brain Research

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In humans, as in other animal species, early caregiver-infant interactions influence physiological and psychological processes by modulating brain sensitivity. Furthermore, early social interaction between caregiver and infant influences infants’ cognitive and socioemotional development, and subsequently the development of social, familial, and romantic relationships later in life. Here, we have collected longitudinal and cross-sectional empirical studies as well as review and perspective articles that focus on human or non-human mammals with the aim to investigate how genetic, hormonal, behavioural, and environmental factors, as well as cultural contexts, regulate early interactional experiences, and how these experiences translate into social and non-social competences later in life (see Graphical Abstract).

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“…Furthermore, in both genotypes, observed disruptive child behavior was positively associated to parental negativity, with the impact being largest in parents with the SS or LS genotype. Sawano et al [16] reached similar conclusions, finding an interactive effect between parenting environment and 5-HTTLPR on maternal attitudes. Specifically, a Different results were obtained by Baio et al [12], who investigated whether 5-HTTLPR moderates the quality of environmental context on maternal sensitivity.…”

Section: Resultsmentioning

confidence: 70%

“…Moreover, several studies have found strong interactions between genetic and environmental factors [2,11,12,16]. Mileva-Seitz et al [11] investigated whether genotype and early caregiving experiences were linked to three dimensions of maternal responsiveness (maternal sensitivity, maternal behaviour away from the child, and maternal attitudes-perceived attachment), and discovered highly significant GXE interactions with maternal behaviour and maternal attitudes.…”

Section: Resultsmentioning

confidence: 99%

“…Four studies showed a direct relationship between 5-HTTLPR and parental caregiving [1,2,11,14], with contrasting results that may prompt future research and hypotheses about different mechanisms acting on this relationship. In addition, several studies found strong interactions between genetic and environmental factors [2,11,12,16], such as infant stress and disruptive infant behaviours [2] , the quality of early care-experiences [11], poor rearing conditions, and the quality of the environment [16]. Most psychological traits and behaviors are better explained by a combination of essential characteristics such as gender and socioeconomic status than by genetic markers alone, as Kagan et al [25] recently argued, though the inclusion of both genetic and environmental factors can predict such outcomes with the greatest accuracy in certain groups.…”

Section: Discussionmentioning

confidence: 99%

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Parenting and the Serotonin Transporter Gene (5HTTLPR), Which Association? A Systematic Review of the Literature

Landoni¹,

Muta²,

Tella³

et al. 2022

Preprint

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The current systematic review examines whether there is an association between the genetic 5-HTTPLR pol-ymorphism and parenting and the mechanisms by which this association operates. The literature was searched in various databases such as PubMed, Scopus and ScienceDirect. In line with our inclusion criteria, nine articles were eligible out of 22. Most of the studies, analysed in this review, found an association between 5HTTLPR and parenting. Four studies found a direct association between 5-HTTLPR and parenting with conflicting findings: two studies found that mothers carrying the short variant were more sensitive to their infants, while two studies found that parents carrying the S allele were less sensitive. In addition, several studies found strong interaction between genetic and environmental factors, such as childhood stress and disruptive child behaviour, quality of early care experiences, poor parenting environment, and quality of environment. Only one study found an association between children’s 5HTTLPR and parenting. Parenting can be described as a highly complex construct influenced by multiple factors, including environmental, parenting and child charac-teristics. According to the studies, maternal 5-HTTLPR polymorphism is most likely associated with sensitive parenting.

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Interactive effects of 5-HTTLPR genotype and rearing environment on affective attitude towards own infant in Japanese mothers

Cited by 4 publications

References 62 publications

Parenting and the Serotonin Transporter Gene (5HTTLPR), Is There an Association? A Systematic Review of the Literature

Parenting and the Serotonin Transporter Gene (5HTTLPR), Is There an Association? A Systematic Review of the Literature

The development of attachment: Integrating genes, brain, behavior, and environment

Parenting and the Serotonin Transporter Gene (5HTTLPR), Which Association? A Systematic Review of the Literature

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