Intercellular Adhesion Molecule 1 (ICAM-1) Gene Variant Is Associated with Coronary Artery Calcification Independent of Soluble ICAM-1 Levels

Lower-extremity arterial calcification as a correlate of coronary artery calcification

“…This would seem a possibility worthy of future research and may help to refine the role of CAC in CAD prediction. A number of studies have reported on the association between specific gene variants and CAC [42][43][44][45][46][47]. Although results are not always consistent, certain of these genes may also predict cardiovascular disease [48][49][50].…”

Association of systemic inflammation with epicardial fat and coronary artery calcification

“…The involved mediators of inflammation are numerous [2][3][4][5][6][7]. The exact mechanisms of vascular calcification remain, however, unknown.…”

Genome‐wide admixture mapping for coronary artery calcification in African Americans: the NHLBI Family Heart Study

“…Identification of the genetic factors (loci or genes) underlying CAC heritability will likely provide valuable knowledge for understanding, preventing, and treating coronary atherosclerosis. Although polymorphisms of a few candidate genes [Pfohl et al, 1998;Kardia et al, 1999;Ellsworth et al, 2001;Reilly et al, 2001Reilly et al, , 2004Fornage et al, 2004;Burdon et al, 2005] and some chromosomal regions [Lange et al, 2002;O'Donnell et al, 2006;North et al, 2007] have been reported to be related to the presence or quantity of CAC, the genetic factors (loci or genes) underlying the strong heritability of CAC have not yet been identified, and relative to other risk factors of CHD, the knowledge of CAC genetic factors still remains limited.…”