Intercellular invasion and the organizational stability of tissues: a role for fibronectin

Armstrong, Peter B.; Armstrong, Margaret T.

doi:10.1016/s0304-419x(00)00003-2

Cited by 44 publications

(35 citation statements)

References 43 publications

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“…Interestingly the same host cell matrix molecules involved in cell invasion by T. cruzi as shown in this study are used as adhesion ligands by tumor cells (40,41).…”

Section: Discussionmentioning

confidence: 70%

In Vitro Selection of RNA Aptamers That Bind to Cell Adhesion Receptors of Trypanosoma cruzi and Inhibit Cell Invasion

Ulrich¹,

Magdesian²,

Alves³

et al. 2002

Journal of Biological Chemistry

145

121

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Trypanosoma cruzi causing Chagas' disease needs to invade host cells to complete its life cycle. Macromolecules on host cell surfaces such as laminin, thrombospondin, heparan sulfate, and fibronectin are believed to be important in mediating parasite-host cell adhesions and in the invasion process of the host cell by the parasite. The SELEX technique (systematic evolution of ligands by exponential enrichment) was used to evolve nuclease-resistant RNA ligands (aptamer ‫؍‬ to fit) that bind with affinities of 40 -400 nM to parasite receptors for the host cell matrix molecules laminin, fibronectin, thrombospondin, and heparan sulfate. After eight consecutive rounds of in vitro selection four classes of RNA aptamers based on structural similarities were isolated and sequenced. All members of each class shared a common sequence motif and competed with the respective host cell matrix molecule that was used for displacement during the selection procedure. RNA pools following seven and eight selection rounds as well as individual aptamers sharing consensus motifs were active in inhibiting invasion of LLC-MK 2 monkey kidney cells by T. cruzi in vitro.

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“…Interestingly the same host cell matrix molecules involved in cell invasion by T. cruzi as shown in this study are used as adhesion ligands by tumor cells (40,41).…”

Section: Discussionmentioning

confidence: 70%

In Vitro Selection of RNA Aptamers That Bind to Cell Adhesion Receptors of Trypanosoma cruzi and Inhibit Cell Invasion

Ulrich¹,

Magdesian²,

Alves³

et al. 2002

Journal of Biological Chemistry

145

121

View full text Add to dashboard Cite

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“…Among the ECM components, some proteins are important due to their regulatory or structural functions. Fibronectin is a glycoprotein, which possesses an important signaling function in cell adhesion and migration [5,17,[20][21][22][23]. Tenascin is another glycoprotein synthesized at speciWc time points and sites during embryogenesis.…”

Section: Discussionmentioning

confidence: 99%

Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors

Medeiros

Nonaka

Galvão

et al. 2009

Eur Arch Otorhinolaryngol

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This study evaluated the expression of Wbronectin, tenascin and type I collagen in ameloblastomas and adenomatoid odontogenic tumors (AOTs) aiming to contribute with the comprehension of the diVerences in the biological behavior of these tumors. Immunohistochemical technique was performed in 20 cases of ameloblastoma (16 solid and 4 desmoplastic) and in 10 cases of AOT. All tumors presented moderate Wbronectin expression in the stroma. Solid ameloblastomas showed intense expression of Wbronectin at the epithelial-mesenchymal interface, whereas desmoplastic ameloblastomas revealed no immunoexpression of Wbronectin at this site. Ameloblastomas presented stronger immunoreactivity to tenascin than AOTs, especially at the epithelial-mesenchymal interface. AOTs and desmoplastic ameloblastomas showed intense labeling for type I collagen. The patterns of expression of the proteins studied agree with the locally more invasive behavior of ameloblastomas in comparison to AOTs. Our results might suggest a less invasive behavior of desmoplastic ameloblastoma in comparison to solid ameloblastoma.

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“…Examination of the differential expression and distribution of extracellular matrix molecules and their cellular receptors suggests that these molecules are likely to regulate coronary vessel development. 13,14,17,18,[25][26][27][28][29] The importance of regulating cell adhesion during PEO migration to and over the heart is exemplified by the genetic analysis of vascular cell adhesion molecule-1 (VCAM-1)/␣ 4 -integrin interaction. VCAM-1 is a cytokine-inducible transmembrane protein of the immunoglobulin superfamily of cell adhesion molecules, and its only known ligand is ␣ 4 ␤ 1 -integrin.…”

Section: Formation Of the Epicardiummentioning

confidence: 99%

Coronary Vessel Development

Wada

Willet

Bader

2003

ATVB

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Abstract-Development of the coronary vascular system is an interesting model in developmental biology with major implications for the clinical setting. Although coronary vessel development is a form of vasculogenesis followed by angiogenesis, this system uses several unique developmental processes not observed in the formation of other blood vessels. This review summarizes the literature that describes the development of the coronary system, highlighting the unique aspects of coronary vessel development. It should be noted that many of the basic mechanisms that govern vasculogenesis in other systems have not been analyzed in coronary vessel development. In addition, we present recent advances in the field that uncover the basic mechanisms regulating the generation of these blood vessels and identify areas in need of additional studies. A Brief Description of Coronary Vessel DevelopmentCoronary vessel development is an example of vasculogenesis followed by angiogenesis with unique variations specific to heart development. Vasculogenesis has been described as the de novo generation of blood vessels, whereas angiogenesis can be thought of as the generation of capillaries, veins, and arteries from preexisting vessels. The process begins with the delivery of vasculogenic cell types to the surface of the heart after beating has begun. These cells must then disperse throughout the heart; differentiate into endothelial cells, smooth muscle cells, pericytes, and fibroblasts; subsequently form arteries, veins, and capillaries; and finally connect to the aorta and coronary sinus. Delivery of a population of cells to an existing organ requires dynamic cellular events, and coordination of cell movement with the precise timing of delivery, commitment, and differentiation is critical for proper vessel formation and organ development. Originally, researchers thought that coronary vascular progenitors were derived from the cardiac mesoderm, like the other cell types in the myocardium and endocardium. 1,2 These data were first challenged by Manasek, 3 who demonstrated that the heart tube is initially composed of only endocardium and myocardium and that the epicardium arises from extracardiac regions. In more recent years, several studies have determined that progenitors of the epicardium and coronary vascular system are derived from extracardiac tissue, the proepicardial organ (PEO; Figure 1). Although the earliest location of these progenitors is still in debate, they appear to arise from splanchnic mesoderm. 4 -6 The PEO is associated with the septum transversum that grows from the dorsal body wall ventrally to divide the embryonic coelom into the pleuropericardial and peritoneal cavities and forms a portion of the diaphragm. 4,[7][8][9] However, the PEO is a transient structure that consists of a single epithelial layer folded into a shape resembling a grapelike cluster. In chicken (HH stage 17) and mouse (E9.5) embryos, the PEO migrates to and then over the surface of the heart to form the primitive epicardium (Figures 1 th...

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Intercellular invasion and the organizational stability of tissues: a role for fibronectin

Cited by 44 publications

References 43 publications

In Vitro Selection of RNA Aptamers That Bind to Cell Adhesion Receptors of Trypanosoma cruzi and Inhibit Cell Invasion

In Vitro Selection of RNA Aptamers That Bind to Cell Adhesion Receptors of Trypanosoma cruzi and Inhibit Cell Invasion

Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors

Coronary Vessel Development

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