Different conductive bonding strategies for the hybrid integration of flexible, inkjet-printed electronics are investigated. The focus of the present work lies on providing a practical guide comprising standard techniques that are inexpensive, easily implementable and frequently used. A sample set consisting of identical conductive test structures on different paper and plastic substrates was prepared using silver (Ag) nanoparticle ink. The sintered specimens were electrically contacted using soldering, adhesive bonding and crimping. Electrical and mechanical characterization before and after exposing the samples to harsh environmental conditions was performed to evaluate the reliability of the bonding methods. Resistance measurements were done before and after connecting the specimens. Afterwards, 85 °C/85% damp-heat tests and tensile tests were applied. Adhesive bonding appears to be the most suitable and versatile method, as it shows adequate stability on all specimen substrates, especially after exposure to a 85 °C/85% damp-heat test. During exposure to mechanical tensile testing, adhesive bonding proved to be the most stable, and forces up to 12 N could be exerted until breakage of the connection. As a drawback, adhesive bonding showed the highest increase in electrical resistance among the different bonding strategies.