Interdigitated electrodes as impedance and capacitance biosensors: A review

Mazlan, N. S.; Ramli, Muhammad M.; Halin, Dewi Suriyani Che; Isa, Salmi Mohd; Talip, L. F. A.; Danial, N. S.; Murad, S. A. Z.

doi:10.1063/1.5002470

Cited by 63 publications

(44 citation statements)

References 15 publications

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“…The impedance spectra alterations of the IDEs devices can be modeled either under Faradic or non-Faradic processes [ 46 ]. We have analyzed the interaction in the non-Faradic process since current flows as a result of the capacitive nature of the electrodes and changes in the impedance are based on changes in the capacitance between the interdigitated electrodes.…”

Section: Resultsmentioning

confidence: 99%

Real-Time Impedance Monitoring of Epithelial Cultures with Inkjet-Printed Interdigitated-Electrode Sensors

Mojena-Medina

Hubl²,

Bäuscher

et al. 2020

Sensors

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From electronic devices to large-area electronics, from individual cells to skin substitutes, printing techniques are providing compelling applications in wide-ranging fields. Research has thus fueled the vision of a hybrid, printing platform to fabricate sensors/electronics and living engineered tissues simultaneously. Following this interest, we have fabricated interdigitated-electrode sensors (IDEs) by inkjet printing to monitor epithelial cell cultures. We have fabricated IDEs using flexible substrates with silver nanoparticles as a conductive element and SU-8 as the passivation layer. Our sensors are cytocompatible, have a topography that simulates microgrooves of 300 µm width and ~4 µm depth, and can be reused for cellular studies without detrimental in the electrical performance. To test the inkjet-printed sensors and demonstrate their potential use for monitoring laboratory-growth skin tissues, we have developed a real-time system and monitored label-free proliferation, migration, and detachment of keratinocytes by impedance spectroscopy. We have found that variations in the impedance correlate linearly to cell densities initially seeded and that the main component influencing the total impedance is the isolated effect of the cell membranes. Results obtained show that impedance can track cellular migration over the surface of the sensors, exhibiting a linear relationship with the standard method of image processing. Our results provide a useful approach for non-destructive in-situ monitoring of processes related to both in vitro epidermal models and wound healing with low-cost ink-jetted sensors. This type of flexible sensor as well as the impedance method are promising for the envisioned hybrid technology of 3D-bioprinted smart skin substitutes with built-in electronics.

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Section: Resultsmentioning

confidence: 99%

Real-Time Impedance Monitoring of Epithelial Cultures with Inkjet-Printed Interdigitated-Electrode Sensors

Mojena-Medina

Hubl²,

Bäuscher

et al. 2020

Sensors

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“…The impedance characteristics, with the simulation results from the sensor output obtained, shows that the impedance of normal breast cells are lower than their cancer counterparts. This output is validated by a number of other practical experiments done on the breast cells [10,11,12,13] for frequency ranges in β-dispersion and lower range of γ dispersion with other methods. The impedance of the cells is also dependent on cell concentration [20].…”

Section: Fig 3 Impedance Characteristics Of Breast Cells Without Mementioning

confidence: 60%

MEMS Based Diagnosis of Breast Cancer

Jogi*,

Gupta

2020

IJITEE

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Based on the fact that the chemical, geometrical and other biophysical characteristics effect the electrical response of cells and tissues, a sensor is proposed which could be utilized for diagnosis and treatment of breast cancer as an economic and easy to use sensor. Endeavor has been made to model an in vitro sensor for early diagnosis of breast cancer considering sample data of normal breast cells (MCF-10A), less invasive cancer breast cells (MCF-7 & T47D) and highly invasive cancer breast cells (MDA-MB-231 & HS-578T). The simulation is done in COMSOL Multiphysics environment to find the impedance and capacitance of the cells with and without culture medium so as to characterize the types of cells. It is found that the impedance decreases sharply from 0.2 to 1 GHz and the normal breast cells could be distinguished from their cancer counter parts by comparing their electrical impedance and capacitance within the given frequency range. Apart from distinguishing normal breast cells from their cancer counterparts, the types of breast cancer cell types could also be determined by the differences in their frequency responses.

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“…Interdigitated electrodes are made in the form of two individual addressable comb-like interdigitated structures. IDEs form part of a group of transducers widely used in metrology where impedance and capacity changes are essential, e.g., in humidity and gas sensors, and in biosensors for tumor cell and cardiac troponin T biomarker detection or in biomedical applications [ 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ]. In the literature, there are also reports on the usage of IDEs in sterility tests in the food industry.…”

Section: Introductionmentioning

confidence: 99%

Prototype of a Textronic Sensor Created with a Physical Vacuum Deposition Process for Staphylococcus aureus Detection

Korzeniewska

Szczęsny

Lipiński

et al. 2020

Sensors

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Staphylococcus aureus is a bacterium which people have been in contact with for thousands of years. Its presence often leads to severe disorders of the respiratory and circulatory systems. The authors of this article present a prototype of a textronic sensor enabling the detection of this bacterium. This sensor was created using a process of physical vacuum deposition on a flexible textile substrate which can be implemented on clothing. With increasing numbers of bacterial colonies, changes in the sensor’s electrical parameters were observed. The sensor’s resistance reduced by 50% and the capacitance more than doubled within the first two days of starting bacterial cultures. Extensive changes in electrical parameters were observed at 100 Hz and 120 Hz of the measurement signal.

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Interdigitated electrodes as impedance and capacitance biosensors: A review

Cited by 63 publications

References 15 publications

Real-Time Impedance Monitoring of Epithelial Cultures with Inkjet-Printed Interdigitated-Electrode Sensors

Real-Time Impedance Monitoring of Epithelial Cultures with Inkjet-Printed Interdigitated-Electrode Sensors

MEMS Based Diagnosis of Breast Cancer

Prototype of a Textronic Sensor Created with a Physical Vacuum Deposition Process for Staphylococcus aureus Detection

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