Interepithelial cells of the oral mucosa in mice

Burkhardt, A; Bos, Inge; Löning, Thomas; Gebbers, Jan‐Olaf; Otto, Herwart F.; Seifert, G.

doi:10.1007/bf00427258

Cited by 27 publications

(2 citation statements)

References 98 publications

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“…Occasionally, however, the Langerhans cell with a round nucleus and Birbeck granules was also identified. Burkhardt et al (1979) reported in their ultrastructural investigation on the oral mucosa in mice that 80.9% of Langerhans cells in the tongue, cheek, and lip showed irregularly indented nuclei, whereas 19.1% of them displayed spherical nuclei. The former were termed macrophagocytoid Langerhans cells and the latter reticuloid Langerhans cells.…”

Section: Discussionmentioning

confidence: 99%

Ultrastructural observation on Langerhans cells in the rat gingival epithelium

Takehana

Kameyama

Satoand

et al. 1985

J of Periodontal Research

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The present study was carried out to investigate ultrastructurally Langerhans cells in the rat gingival epithelium. The gingivae of lower incisors of 15 Wistar rats were examined by electron microscopy. The results were as follows: Langerhans cells were observed mainly in the lower prickle-cell layer of the gingival epithelium. On rare occasions Langerhans cells were also found in the basal and granular layers. The average number of Langerhans cells per 100 cells in the prickle-cell layer was 1.0 cell. Usually Langerhans cells had clear cytoplasms and convoluted or indented nuclei, although sometimes the cells exhibited round nuclei. The clear cytoplasm contained a moderately developed Golgi apparatus and a small number of rough surfaced endoplasmic reticulum, free ribosomes, mitochondria, and lysosomes, but it lacked tonofllaments. Birbeck granules were often found in close vicinity of the Golgi apparatus. The average number of Birbeck granules per one Langerhans cell was 4.3 granules. The cell membrane of Langerhans cells had no junctionai complexes hke desmosomes. The degeneration of keratinocytes adjacent to Langerhans cells was observed in a few specimens.

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Section: Discussionmentioning

confidence: 99%

Ultrastructural observation on Langerhans cells in the rat gingival epithelium

Takehana

Kameyama

Satoand

et al. 1985

J of Periodontal Research

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“…Langerhans' cells with characteristic ultrastructural features are present in oral mucosal epithelia (Schroeder & Theilade 1966), but have not been extensively studied. Their regional distribution in Rhesus monkey and developing rat palatal mucosa has been examined , Hill 1977, and quantitative and qualitative differences in Langerhans' cells between regions of the oral mucosa of athymic, germ-free, candidal-infected and conventional mice have been demonstrated (Bos & Burkhardt 1980, Burkhardt et al 1979.…”

Section: Langerhans' Cellsmentioning

confidence: 99%

Recent advances in oral mucosal research

Mackenzie

Binnie

1983

J Oral Pathology Medicine

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Lymphocyte Subsets and Langerhans' Cells in Toxic Epidermal Necrolysis

Mérot¹

1986

Arch Dermatol

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Toxic epidermal necrolysis is a life-threatening disease, the pathogenesis of which remains largely unknown. Histologically, in addition to the characteristic epidermal alterations, there is a sparse mononuclear cell infiltrate in the dermis. The immunologic characteristics of this infiltrate are not well known. In a case of drug-induced toxic epidermal necrolysis with fatal outcome in a 48-year-old man, we demonstrated that the majority of the inflammatory cells were of helper/inducer T-lymphocyte subsets, having only a minority of cytotoxic/suppressor T-lymphocytes and rare cells with natural killer cell phenotype. The significance of these observations is discussed, with reference to the occurrence of lesions at epithelial sites bearing local networks of antigen-presenting cells (Langerhans' cells).

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Interepithelial cells of the oral mucosa in mice

Cited by 27 publications

References 98 publications

Ultrastructural observation on Langerhans cells in the rat gingival epithelium

Ultrastructural observation on Langerhans cells in the rat gingival epithelium

Recent advances in oral mucosal research

Lymphocyte Subsets and Langerhans' Cells in Toxic Epidermal Necrolysis

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