This study aims to analyze and obtain empirical evidence regarding the effect of LDR on bank's profitability, and the variables that can moderate the influence of LDR on ROA. The object of this research is banks listed on the Indonesia Stock Exchange for the period of 2013 to 2016. 25 banks were selected using the purposive sampling method. The research object was divided into two categories, namely BUKU 1 and BUKU 2 banks, and BUKU 3 and BUKU 4 banks. The results showed that BUKU 1 and BUKU 2 banks were influenced by LDR and BI rate. Then, it moderated by OEOI. The study does not support the hypothesis that the NPL and NIM of BUKU 1 and BUKU 2 banks can moderate the influence of the LDR variable on ROA. While the influence of LDR on ROA of BUKU 3 and BUKU 4 banks was moderated by NIM and OEOI. The study does not support the hypothesis that the NPL of BUKU 3 and BUKU 4 banks can moderate the influence of the LDR variable on ROA.This study also supports the statement that the BI rate gives more influence to BUKU 1 and BUKU 2 banks than banks in the BUKU 3 and BUKU 4 categories.