Interesting Lesions of Bone Marrow With Special Reference to Metastasis

Abstract

BACKGROUND:Bone marrow examination is a commonly used diagnostic modality in the evaluation of hemato-oncological disorders and in patients with malignancies of visceral organs to detect metastasis. This study reviews clinical, hematological and pathological data of interesting cases with bone marrow involvement. Out of 490 bone marrow aspirations performed during a period of 4 years, 5 cases show metastatic carcinomatous deposits which included adenocarcinomas(3), squamous cell carcinoma(1) and neuroendocrine tumour(1), Non-Hodgkins lymphomas(2), storage disorder(2), granulomatous lesions(1), gelatinous transformation(1). Fever, generalized weakness, loss of appetite and loss of weight were the main symptoms. Anemia and pancytopenia were the main hematological findings. Dry tap was a significant finding in bone marrow aspiration in cases of metastatic cancers.