Intérêt de la radiothérapie postopératoire dans la prise en charge des sarcomes rétropéritonéaux primitifs : expérience du centre Alexis-Vautrin

Call for improved design and reporting in soft tissue sarcoma studies: A systematic review and meta‐analysis of chemotherapy and survival outcomes in resectable STS

“…All observational studies were assessed using the Newcastle‐Ottawa Scale for cohort studies (Table B). Risk of selection bias was low in all studies except Fuks et al, which did not report details pertaining to their population derivation . Comparability between intervention and control groups contributed a low ROB in five of eight studies; the remaining three studies were felt to have poor comparability on the basis of design or analysis.…”

“…Three studies allowed any chemotherapy in keeping with regional standards; the remainder assessed anthracycline‐based regimens +/− ifosfamide. Two studies examined only retroperitoneum (RPS), whereas three studies examined only extremity STS . All other studies evaluated mixed tumor sites; extremity sarcomas were predominant with the exception of one study that studied a majoritively head and neck population .…”

“…All but two studies examined populations of mixed histologies: one investigated 28 patients with angiosarcoma and the other examined 126 patients with extremity liposarcoma . Five studies investigated only adjuvant chemotherapy . No subset analyses were completed on the basis of radiotherapy status, as most studies allowed but did not require radiotherapy as a part of perioperative management.…”

The Role of Radiation in Retroperitoneal Sarcomas

“…Fifty patients with primary RPS treated with curative surgery at Centre Alexis Vautrin were analyzed; 5-year OS and disease-free survival (DFS) were 46% and 19%, respectively [37]. PORT was associated with longer time to recurrence (27 vs 13 months, p = 0.05) and had a favorable impact on OS in univariate analysis, however, the significance was lost in multivariate analysis.…”

“…Generally a policy to include the surgical bed with appropriate margins to cover microscopic disease while avoiding critical structures has been followed for PORT. In the 3D-planning era, PORT is typically targeted to a 3–5 cm expansion on the tumor bed with appropriate anatomic modifications [9, 26, 37, 50]. When planning PreRT, the GTV is expanded using similar margins to generate a PTV [9, 26].…”