The Role of Radiation in Retroperitoneal Sarcomas

Prognostic factors of primary resected retroperitoneal soft tissue sarcoma: Analysis from a single asian tertiary center and external validation of gronchi's nomogram

“…A study based on The Surveillance, Epidemiology, and End Results (SEER) database concluded that adjuvant radiation significantly improved OS (HR = 0.8, P = 0.025) ; however, it included only 483 patients due to poor accrual. Preoperative radiation therapy provides higher chance of successful delivery in the clinical practice because of less toxicity, better efficacy, and greater compliance . There remains considerable controversy regarding the role of radiation in retroperitoneal sarcoma because the lack of randomized prospective study and a number of small studies of preoperative radiation therapy varied with the dose and fractionation of radiotherapy, regimen of concurrent chemotherapy, and methods of delivery (EBRT or brachytherapy).…”

Retroperitoneal Liposarcoma: Current Insights in Diagnosis and Treatment

“…In patients with soft tissue sarcoma of the extremity, two small randomized trials have shown that postoperatiive external beam radiotherapy or brachytherapy improve local control, but do not benefit overall survival ( 115 – 117 ). In retroperitoneal soft tissue sarcoma, a myriad of small trials has been published, which show marked variation in RT dose, fractionation, concurrent use of chemotherapy, delivery method (external beam or brachytherapy), timing (preoperative, intraoperative, or postoperative), and energy carrier (photons, electrons, protons, or carbon ions) ( 118 ).…”

Surgical management of retroperitoneal and pelvic sarcomas

“…Newer radiation therapy technologies have been applied to patients with RPS in order to decrease treatment‐related morbidities. These technologies, including 3D conformal, intensity‐modulated (IMRT) and proton‐beam (PBRT) , can more precisely target the tumor and critical margins, and thereby decrease delivery of radiation to adjacent organs and structures. Short‐term follow‐up of small series of patients treated with these technologies has established their safety and promising efficacy in decreasing LR .…”