Interexaminer Reproducibility of Optical Coherence Tomography for Measuring the Tear Film Meniscus

Canan, Handan; Altan-Yaycıoğlu, Rana; Ulas, Burak; Çoban-Karataş, Müge

doi:10.3109/02713683.2014.898311

Cited by 28 publications

(23 citation statements)

References 25 publications

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“…12,30 These results are in agreement with our study. In this study, we also found the TMH measured with the keratograph to be repeatable and reproducible on a similar level to FD-OCT. Good repeatability and reproducibility were demonstrated by a low intraexaminer (6.4% and 6.5%, respectively) and interexaminer CoV% (5.6%) and the high overall ICCs (98.7% and 98.6%, respectively).…”

Section: Discussionsupporting

confidence: 93%

Comparison of Tear Meniscus Height Measurements Obtained With the Keratograph and Fourier Domain Optical Coherence Tomography in Dry Eye

Baek

Doh

Chung

2015

Cornea

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Section: Discussionsupporting

confidence: 93%

Comparison of Tear Meniscus Height Measurements Obtained With the Keratograph and Fourier Domain Optical Coherence Tomography in Dry Eye

Baek

Doh

Chung

2015

Cornea

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“…Points on the grading scale that did not occur in any group are not shown. Palakuru et al 2007Palakuru et al , 2008Ibrahim et al 2010;Koh et al 2010;Chen et al 2011;Park et al 2012;Qiu et al 2012;Altan-Yaycioglu et al 2013;Fukuda et al 2013;Bartuzel et al 2014;Canan et al 2014;Sizmaz et al 2014;Akiyama et al 2015;Tukenmez-Dikmen et al 2015). For measuring precorneal tear film, the resolution of commercially available OCT systems is not sufficient for quantitative measurement.…”

Section: Discussionmentioning

confidence: 99%

Effect of different lubricant eye gels on tear film thickness as measured with ultrahigh‐resolution optical coherence tomography

Woźniak

Schmidl

Bata

et al. 2016

Acta Ophthalmologica

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“…However, some studies have shown repeatability and reproducibility in using OCT to measure TMA and TMD. 120,122 They also have been shown to correlate with DED and traditional measurements for DED. 116,119,120 However, TMA and TMD measurements using OCT have not yet been incorporated in any multicenter clinical trial.…”

Section: Point Of Care Biomarkersmentioning

confidence: 93%

“…97,110–120 Some studies suggest there is good repeatability and reproducibility of TMH measurements in DED and normals. 101,114,115,118,120–122 However, TMH taken with different machines may not be comparable. 111,115,121 …”

Section: Point Of Care Biomarkersmentioning

confidence: 99%

The Growing Need for Validated Biomarkers and Endpoints for Dry Eye Clinical Research

Roy

Wei

Kuklinski

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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PurposeBiomarkers with minimally invasive and reproducible objective metrics provide the key to future paradigm shifts in understanding of the underlying causes of dry eye disease (DED) and approaches to treatment of DED. We review biomarkers and their validity in providing objective metrics for DED clinical research and patient care.MethodsThe English-language literature in PubMed primarily over the last decade was surveyed for studies related to identification of biomarkers of DED: (1) inflammation, (2) point-of-care, (3) ocular imaging, and (4) genetics. Relevant studies in each group were individually evaluated for (1) methodological and analytical details, (2) data and concordance with other similar studies, and (3) potential to serve as validated biomarkers with objective metrics.ResultsSignificant work has been done to identify biomarkers for DED clinical trials and for patient care. Interstudy variation among studies dealing with the same biomarker type was high. This could be attributed to biologic variations and/or differences in processing, and data analysis. Correlation with other signs and symptoms of DED was not always clear or present.ConclusionsMany of the biomarkers reviewed show the potential to serve as validated and objective metrics for clinical research and patient care in DED. Interstudy variation for a given biomarker emphasizes the need for detailed reporting of study methodology, including information on subject characteristics, quality control, processing, and analysis methods to optimize development of nonsubjective metrics. Biomarker development offers a rich opportunity to significantly move forward clinical research and patient care in DED.OverviewDED is an unmet medical need — a chronic pain syndrome associated with variable vision that affects quality of life, is common with advancing age, interferes with the comfortable use of contact lenses, and can diminish results of eye surgeries, such as cataract extraction, LASIK, and glaucoma procedures. It is a worldwide medical challenge with a prevalence rate ranging from 8% to 50%. Many clinicians and researchers across the globe are searching for better answers to understand the mechanisms related to the development and chronicity of DED. Though there have been many clinical trials for DED, few new treatments have emerged over the last decade. Biomarkers may provide the needed breakthrough to propel our understanding of DED to the next level and the potential to realize our goal of truly personalized medicine based on scientific evidence. Clinical trials and research on DED have suffered from the lack of validated biomarkers and less than objective and reproducible endpoints. Current work on biomarkers has provided the groundwork to move forward. This review highlights primarily ocular biomarkers that have been investigated for use in DED, discusses the methodologic outcomes in providing objective metrics for clinical research, and suggests recommendations for further work.

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Interexaminer Reproducibility of Optical Coherence Tomography for Measuring the Tear Film Meniscus

Abstract: We showed a strong statistical agreement for both TMA and TMH measurements. According to our results, we believe that FD-OCT device is dependable in measuring the TMA and TMH values, given that its results are reproducible.

Cited by 28 publications

References 25 publications

Comparison of Tear Meniscus Height Measurements Obtained With the Keratograph and Fourier Domain Optical Coherence Tomography in Dry Eye

Comparison of Tear Meniscus Height Measurements Obtained With the Keratograph and Fourier Domain Optical Coherence Tomography in Dry Eye

Effect of different lubricant eye gels on tear film thickness as measured with ultrahigh‐resolution optical coherence tomography

The Growing Need for Validated Biomarkers and Endpoints for Dry Eye Clinical Research

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