Interface Dynamics of Lipid Membrane Spreading on Solid Surfaces

Nissen, J.; Jacobs, Karin; Rädler, Joachim O.

doi:10.1103/physrevlett.86.1904

Cited by 53 publications

(69 citation statements)

References 22 publications

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“…Lipid spreading on solid surfaces has been well studied by time-lapse fluorescence microscopy (Nissen et al 1999(Nissen et al , 2001Radler et al 1995;Sanii and Parikh 2007). The spreading kinetics of a lipid bilayer on hydrophilic surfaces or of a monolayer on hydrophobic surfaces can be quantitatively described by means of adhesion theory as a balance between the spreading force and the resistive drag.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, surface-supported bilayers under water are useful as model membrane systems (Sackmann 1996), and phospholipid interactions with surfaces can provide insights into lipid nanodynamic processes (Nissen et al 1999(Nissen et al , 2001Radler et al 1995;Sanii and Parikh 2007). Fluid phospholipids such as 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) are particularly well suited as inks for DPN in air because their viscosity and corresponding ink transport properties can be controlled by relative humidity (Lenhert et al 2007).…”

Section: Introductionmentioning

confidence: 99%

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In situ lipid dip‐pen nanolithography under water

2010

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Lipids form the structural and functional basis of biological membranes, and methods for studying their self-organization in well-defined nano- and micro-scale model systems can provide insights into biology. Using lipids as an ink for dip-pen nanolithography (lipid DPN) permits the rapid nanostructuring of multicomponent model lipid membrane systems, but this technique has so far been limited to air. Here we demonstrate that lipid DPN can be carried out under water with single tips or parallel arrays. Using the same tip for deposition and imaging in aqueous solution permits imaging of self-spreading lipid bilayer spots in situ and quantification of the nanoscale spreading kinetics in real time by means of lateral-force microscopy. Furthermore, using fluorophore-labeled phospholipids, we directly observed, by confocal laser scanning microscopy, a two-phase (oil in water) meniscus formed around the contact point between the DPN tip and surface, gaining insights into the mechanisms of the ink transport. The methods described here provide a new tool and environment for high-resolution studies of lipid nanodynamics and molecular printing processes in general.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In situ lipid dip‐pen nanolithography under water

2010

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“…While surface roughness will intrinsically be accounted for in our modelling by its influence on surface diffusion, larger surface defects leading to uneven flow and pinning effects 50,69 will not be regarded, as L-DPN is performed typically on extensively cleaned and homogeneous substrates where defective surfaces are usually discarded.…”

Section: Step Iii: Surface Spreadingmentioning

confidence: 99%

A diffusive ink transport model for lipid dip-pen nanolithography

Urtizberea

Hirtz

2015

Nanoscale

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Despite diverse applications, phospholipid membrane stacks generated by dip-pen nanolithography (DPN) still lack a thorough and systematic characterization that elucidates the whole ink transport process from writing to surface spreading, with the aim of better controlling the resulting feature size and resolution. We report a quantitative analysis and modeling of the dependence of lipid DPN features (area, height and volume) on dwell time and relative humidity. The ink flow rate increases with humidity in agreement with meniscus size growth, determining the overall feature size. The observed time dependence indicates the existence of a balance between surface spreading and the ink flow rate that promotes differences in concentration at the meniscus/substrate interface. Feature shape is controlled by the substrate surface energy. The results are analyzed within a modified model for the ink transport of diffusive inks. At any humidity the dependence of the area spread on the dwell time shows two diffusion regimes: at short dwell times growth is controlled by meniscus diffusion while at long dwell times surface diffusion governs the process. The critical point for the switch of regime depends on the humidity.

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“…For example, the use of spontaneous growth of lipid bilayer enables to transport any molecule in the bilayer toward any direction without applying any external biases [7][8][9][10]. This effect is known as the self-spreading behavior of lipid bilayer.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Molecular Filtering at Nano-channel by using Self-spreading Lipid Bilayer as Molecular Transport and Filtering Medium

Nabika

Fukagawa

Murakoshi

2012

Trans. Mat. Res. Soc. Japan

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The self-spreading behavior of DMPC bilayer containing TR-DHPE molecule was observed in the presence of channel-type nano-architecture (nano-channel). The concentration of TR-DHPE at the spreading edge region was gradually decreased by passing through the nano-channel. The filtering efficiency was increased by elongating the channel-length, which was explained by considering a formation of a local compressed state of the spreading bilayer in the elongated channel region. In addition to the channel length, the filtering effect was found to be tuned by the channel angle (entrance angle). These two dependencies are important for precise control of filtering efficiency and selectivity.

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Interface Dynamics of Lipid Membrane Spreading on Solid Surfaces

Cited by 53 publications

References 22 publications

In situ lipid dip‐pen nanolithography under water

In situ lipid dip‐pen nanolithography under water

A diffusive ink transport model for lipid dip-pen nanolithography

Enhanced Molecular Filtering at Nano-channel by using Self-spreading Lipid Bilayer as Molecular Transport and Filtering Medium

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