Interfacial properties of hydrophilized poly(lactic-co-glycolic acid) layers with various thicknesses

Gyulai, Gergö; Pénzes, Csanád Botond; Mohai, M.; Lohner, T.; Petrik, P.; Kurunczi, Sándor; Kiss, Éva

doi:10.1016/j.jcis.2011.06.055

Cited by 22 publications

(12 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Solvent residues were removed by heating the samples to 60 °C above the glass transition temperature of the polymers. This also promotes the accumulation of Pluronic in the upper layers of the polymer mixture as was shown previously [19,32]. Prior to contact angle measurements the samples were equilibrated in water for 1 h to approximate the state of the polymers to those on the nanoparticle sols.…”

Section: Wettability Of Plga and Plga-pluronic Surfacesmentioning

confidence: 94%

“…Poly(lactic-co-glycolic acid) (PLGA) nano-and microparticles have been described as convenient platforms to carry drug molecules in the body [15,16,17]. Surface modification of these biodegradable particles with polyethylene oxide containing molecules has been shown to increase the biocompatibility of these systems [18,19,20,21]. Interfacial interactions play an essential role in drug delivery as drug carrier particles have to pass several interfaces in the body before they reach the site of action.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Interaction of poly(lactic-co-glycolic acid) nanoparticles at fluid interfaces

Gyulai

Kiss

2017

Journal of Colloid and Interface Science

View full text Add to dashboard Cite

Interfacial adsorption and its kinetics were explained by the diffusion controlled adsorption theory and considering the energy barrier of particle transport to the interface. Surface modification by Pluronic increased the interfacial activity of nanoparticles at all interfaces. Surface activity of PLGA-Pluronic particles could be described by the contributions of both the PLGA NPs and the effective portion of their Pluronic shell. Both particle films present mainly elastic dilatational properties suggesting that particles are in kinetically separated state.

show abstract

Section: Wettability Of Plga and Plga-pluronic Surfacesmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Interaction of poly(lactic-co-glycolic acid) nanoparticles at fluid interfaces

Gyulai

Kiss

2017

Journal of Colloid and Interface Science

View full text Add to dashboard Cite

show abstract

“…The appearance of terminal amino groups in Pluronic was detected by ninhydrin test. The functionalization yield was above 70% according to 13 C NMR measurements. 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) was purchased from Sigma-Aldrich (purity >99%) and used to form the lipid monolayer in the Langmuir trough.…”

Section: Methodsmentioning

confidence: 99%

“…The activation and chemical coupling [9,10] yields a stable layer but is accompanied by partial degradation of the polyester. The PEG-containing triblock copolymer (Pluronic) proved to be an efficient surface modifier which can be applied in a blend form since it is miscible with PLGA in a certain concentration range depending on their composition [11][12][13]. The adsorption of Pluronic is however, the most simple and straightforward method to coat PLGA nanoparticles [5].…”

Section: Introductionmentioning

confidence: 99%

Tuneable surface modification of PLGA nanoparticles carrying new antitubercular drug candidate

Kiss

Gyulai

Pénzes

et al. 2014

Colloids and Surfaces A: Physicochemical and Engineering Aspect

Self Cite

View full text Add to dashboard Cite

Biodegradable poly(lactic-co-glycolic acid)(PLGA 50:50) nanoparticles (NPs) were prepared and characterized in terms of size, composition, zeta potential and colloidal stability. Surface modification of PLGA NPs where primary amino groups were introduced to the Pluronic surface layer was developed. This method allows modulation of the charge character of the nanoparticle surface and provides functional groups for chemical reactions useful for targeting while retaining the aggregation stability of the system. The nanoparticles showed significant interaction with model membrane system (DPPC and DPPC+DPPG lipid layers) depending on the amount and type of Pluronic applied for stabilization of NPs. A new antitubercular drug candidate was encapsulated into the PLGA NPs. The cellular uptake and the intracellular efficacy against Mycobacterium tuberculosis (Mtb) of the drug and the drug loaded nanoparticulate systems were investigated. These formulations were successfully taken up by MonoMac6 human monocyte cells and highly enhanced the availability and efficacy of the drug against Mtb which was demonstrated in comparative in vitro experiments.

show abstract

“…Egy másik eljárás, a keverékképzés során megállapítottuk, hogy a Pluronic adalék nagymértékben dúsul a politejsav (PLA), politejsav/glikolsav polimerek (PLGA) felületi rétegében, ezáltal így is megvalósítható a felületmódosítás. 10…”

Section: Polimerek Felületmódosításaunclassified