Interfacing Soft and Hard Materials with Triple-Shape-Memory and Self-Healing Functions

Arğun, Aslıhan; Gulyuz, Umit; Okay, Oğuz

doi:10.1021/acs.macromol.8b00233

Cited by 39 publications

(32 citation statements)

References 40 publications

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“…Boronate ester hydrogel could be designed to have shape memory ability via pH value variation [52]. The hydrogel composed of N,N-dimethylacrylamide and other acrylate moieties was reported to have the capability of shape memory through exposing to UV light [49]. In previous researches, PU NPs with different oligodiols as the soft segment possess thermal induced shape memory behavior [48, 50].…”

Section: Smart Polymeric Materials In Biomedicinementioning

confidence: 99%

Smart polymers for cell therapy and precision medicine

et al. 2019

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Soft materials have been developed very rapidly in the biomedical field over the past 10 years because of advances in medical devices, cell therapy, and 3D printing for precision medicine. Smart polymers are one category of soft materials that respond to environmental changes. One typical example is the thermally-responsive polymers, which are widely used as cell carriers and in 3D printing. Self-healing polymers are one type of smart polymers that have the capacity to recover the structure after repeated damages and are often injectable through needles. Shape memory polymers are another type with the ability to memorize their original shape. These smart polymers can be used as cell/drug/protein carriers. Their injectability and shape memory performance allow them to be applied in bioprinting, minimally invasive surgery, and precision medicine. This review will describe the general materials design, characterization, as well as the current progresses and challenges of these smart polymers.

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Section: Smart Polymeric Materials In Biomedicinementioning

confidence: 99%

Smart polymers for cell therapy and precision medicine

et al. 2019

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“…It remains difficult to develop strategies that can achieve both self‐recovery ability and high toughness. During the past decades, many efforts on self‐recovery of hydrogel have been devoted in this regard by introducing different non‐covalent cross‐linkers, including ionic bond, hydrogen bond, coordination, microcrystalline, and hydrophobic interaction . Although these non‐covalent bonds can significantly improve the extensibility and self‐recovery of hydrogels, they usually dramatically reduce the toughness.…”

Section: Introductionmentioning

confidence: 99%

Bioinspired Strategy to Reinforce Hydrogels via Cooperative Effect of Dual Physical Cross‐Linkers

Liang

Zhou

et al. 2020

Macro Chemistry & Physics

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including ionic bond, [4][5][6][7][8][9] hydrogen bond, [10][11][12][13][14][15] coordination, [16][17][18] microcrystalline, [19][20][21] and hydrophobic interaction. [22][23][24][25] Although these non-covalent bonds can significantly improve the extensibility and self-recovery of hydrogels, they usually dramatically reduce the toughness. Covalent cross-linkers are always required for reaching high toughness, whereas the permanent fracture of covalent cross-links will lead to irreversible structure damage and significant decline of toughness and mechanical strength. Without the help from covalent cross-linkers, what kind of multiple physical cross-linker system can endow mono-network hydrogels with both rapid self-recovery and high toughness still remains a challenge.Our strategy is inspired by the nacre of abalone shell, which is constituted by alternating layers of CaCO 3 and biopolymers. The hard CaCO 3 layer provides strength and hardness and the soft biopolymer layer provides adhesion and ductility. The cooperative effect of two components leads to eminent strength and toughness. [26,27] This naturally suggests a new strategy to construct high toughness materials via combining both weak and strong non-covalent cross-linkers in one polymeric network. Polyacrylic acid will be an appropriate candidate for the versatile functions of carboxyl group to realize two different interactions in one polymeric network. First, carboxyl groups are able to form ionic bond with alkaline group, such as primary amine and pyridine. [28] Second, carboxyl groups can coordinate with metal ions, such as Al 3+ and Fe 3+ . [29] In this work, we present a new class of polyacrylic acid hydrogels cross-linked by coordinate bonds with Al 3+ and ionic bonds with triamine (diethylenetriamine, DETA). Compared to Al 3+ or DETA cross-linked hydrogels, this dual physically cross-linked hydrogel become super tough and the toughness of hydrogels can be recovered rapidly. In addition, the mechanical properties can be tuned over a wide range by using different molar ratios of cross-linkers. Experimental Section MaterialsDETA, acrylic acid (AAc), ammonium persulfate (APS), and aluminum chloride (AlCl 3 ) were purchased from Aladdin Many biological tissues including cartilage and tendons are composed of polymeric hydrogels, which exhibit high toughness and rapid self-recovery. However, developing hydrogels with both high toughness and rapid recovery remains a challenge. Inspired by the nacre of abalone shell, two non-covalent cross-linkers (Al 3+ and diethylenetriamine [DETA]) with different relaxation times are introduced into a polyacrylic acid network. Compared with mono cross-linked hydrogels, the dual physical cross-linked hydrogel exhibits both high toughness (work of extension at fracture up to 8.0 MJ m −3 ) and rapid self-recovery ability without loss of extensibility. Strong carboxylate-DETA ionic cross-links with longer relaxation time endow the hydrogels with high strength and help to localize the reformation of carboxylate-Al 3+ coordi...

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“…Considering the mechanical properties of hybrids summarized above, they are unsuitable for stress‐bearing applications. Our research group recently developed the stratification technique to produce high‐strength, two‐segmented hybrid hydrogels exhibiting self‐healing and pseudo triple shape‐memory effects . By adjusting the densities of two monomer solutions, we were able to generate layers by a limited diffusion at a narrow interface.…”

Section: Introductionmentioning

confidence: 99%

Semi‐Crystalline, Three‐Segmented Hybrid Gels with Multiple Shape‐Memory Effect

Arğun

Gulyuz

Okay

2019

Macromolecular Symposia

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Natural biological systems such as intervertebral disk, tendon, and ligament consist of regions with distinctly different mechanical properties, yet these regions intermesh with each other through an extremely tough interface. Here the authors present mechanically strong, three‐segmented hybrid hydrogels comprising of soft and hard components in a fused body resembling the mechanical heterogeneity of biological materials. An easy UV‐initiated bulk copolymerization method of stratified monomer solutions is used to synthesize three‐segmented hybrid hydrogels. In this method, stratification of the monomer solutions is created by means of the differences in their densities. Thus, the polymerization reactions in the monomer mixtures as well as in the interface regions occur simultaneously resulting in the formation of multi‐segmented hybrid hydrogels consisting of segments with different chemical and physical properties. Hydrophilic and hydrophobic monomer mixtures compositions of stratified solutions selected in this study lead to the formation of supramolecular, semi‐crystalline three‐segmented hybrid hydrogels with adjustable thermal and mechanical properties. They also exhibit thermally induced pseudo multiple shape‐memory function originating from distinctly different melting temperatures of crystalline domains belonging to the gel components of hybrids.

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Interfacing Soft and Hard Materials with Triple-Shape-Memory and Self-Healing Functions

Cited by 39 publications

References 40 publications

Smart polymers for cell therapy and precision medicine

Smart polymers for cell therapy and precision medicine

Bioinspired Strategy to Reinforce Hydrogels via Cooperative Effect of Dual Physical Cross‐Linkers

Semi‐Crystalline, Three‐Segmented Hybrid Gels with Multiple Shape‐Memory Effect

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